Detailed information NTG0338221

Bioinformatically predicted

Overview

• Name: clpE
• Type: Regulator
• Locus tag: EQH21_RS03735
• Genome accession: NZ_CP035259
• Coordinates: 737824..740082 (-)
• Length: 752 a.a.
• NCBI ID: WP_000882522.1
• Uniprot ID: A0A0B7M9N8
• Organism: Streptococcus pneumoniae strain TVO_1901926
• Function: degradation of ComX (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IScluster/Tn	736767..741859	737824..740082	within	0

Gene organization within MGE regions

Location: 736767..741859

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH21_RS03730 (EQH21_03925)	-	736767..737617 (+)	851	Protein_750	IS630 family transposase	-
EQH21_RS03735 (EQH21_03930)	clpE	737824..740082 (-)	2259	WP_000882522.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
EQH21_RS03740 (EQH21_03935)	-	740311..740541 (-)	231	WP_000443573.1	YkuJ family protein	-
EQH21_RS03745 (EQH21_03940)	-	740906..741859 (+)	954	WP_001155321.1	IS30-like element ISSpn8 family transposase	-

Sequence

Protein

• Length: 752 a.a.
• Molecular weight: 83870.29 Da
• Isoelectric Point: 5.3713

>NTDB_id=338221 EQH21_RS03735 WP_000882522.1 737824..740082(-) (clpE) [Streptococcus pneumoniae strain TVO_1901926]
MLCQNCKINDSTIHLYTNLNGKQKQIDLCQNCYKIIKTDPNNSLFKGMTDLNNRDFDPFGDFFNDLNNFRPSSNTPPIPP
TQSGGGYGGNGGYGSQNRGSAQTPPPSQEKGLLEEFGINVTEIARRGDIDPVIGRDDEIIRVIEILNRRTKNNPVLIGEP
GVGKTAVVEGLAQKIVDGDVPHKLQGKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRKREDIILFIDEIHEIVGAGSA
SDGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPTVDETITILKGIQKKYEDYHHVQYTDAA
IEAAATLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKVIDQRLIEAENLKSQATREEDFEKAAYFRDQIAKYKEM
QKKKITDQDTPIISEKTIEHIIEQKTNIPVGDLKEKEQSQLIHLAEDLKSHVIGQDDAVDKIAKAIRRNRVGLGTPNRPI
GSFLFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHSVAKLVGAPPGYVGYDEAGQLTEKVRHNPYSLILLDE
VEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDAIIIMTSNAGTGKTEASVGFGATREGRTNSVLGELGNFFSPEFMNRF
DGIIEFKALSKDNLLQIVELMLADVNKRLSSNNIRLDVTDKVKEKLVDLGYDPKMGARPLRRTIQDYIEDTITDYYLENP
SEKDLKAVMTSKGNIQIKSAKKAEVKSSEKEK

Nucleotide

• Length: 2259 bp

>NTDB_id=338221 EQH21_RS03735 WP_000882522.1 737824..740082(-) (clpE) [Streptococcus pneumoniae strain TVO_1901926]
ATGCTTTGTCAAAACTGTAAAATTAACGACTCAACAATTCATCTTTACACCAATCTCAATGGAAAACAAAAACAAATTGA
CCTCTGTCAAAACTGCTATAAGATTATCAAAACAGATCCTAACAATAGCCTCTTCAAAGGTATGACGGATCTGAACAATC
GTGACTTCGATCCCTTTGGTGATTTCTTCAATGATCTAAACAATTTCAGACCTTCTAGCAATACTCCTCCTATTCCCCCA
ACCCAATCAGGTGGAGGTTACGGTGGAAACGGCGGTTATGGTTCCCAAAATCGTGGATCTGCTCAAACTCCGCCACCTAG
CCAAGAAAAAGGCCTGCTGGAAGAATTTGGTATTAATGTAACTGAAATTGCCCGTCGTGGAGACATTGACCCCGTTATTG
GGCGCGACGATGAGATTATCCGTGTCATCGAGATTCTCAATCGTAGAACCAAGAATAATCCTGTCCTTATCGGTGAACCT
GGTGTCGGAAAAACGGCCGTTGTCGAAGGTCTAGCTCAGAAAATTGTCGATGGCGATGTGCCACATAAACTCCAAGGTAA
ACAAGTCATCCGTCTGGATGTGGTTAGCTTAGTTCAAGGAACGGGGATTCGAGGACAATTTGAAGAACGCATGCAAAAAC
TCATGGAAGAAATTCGCAAACGTGAAGACATCATCCTCTTTATCGATGAAATCCATGAAATTGTTGGTGCTGGTTCTGCG
AGTGATGGTAATATGGACGCAGGAAATATCCTCAAGCCAGCCCTTGCTCGTGGAGAACTGCAACTAGTCGGTGCTACTAC
CCTCAATGAATACCGTATCATTGAAAAGGATGCTGCCCTCGAGCGTCGTATGCAGCCTGTTAAAGTCGATGAACCAACGG
TGGACGAAACAATCACTATTCTCAAAGGGATTCAAAAGAAATACGAAGATTACCACCACGTTCAATATACCGATGCTGCG
ATTGAAGCAGCTGCAACTCTTTCCAATCGCTACATCCAAGATCGCTTCTTGCCTGACAAGGCCATTGACCTCCTAGATGA
AGCTGGTTCTAAGATGAACTTGACCTTGAATTTTGTGGATCCTAAAGTAATTGATCAGCGCTTGATTGAGGCTGAAAATC
TCAAGTCTCAAGCTACACGAGAAGAAGATTTTGAGAAGGCGGCCTACTTCCGCGACCAGATTGCCAAGTATAAGGAAATG
CAAAAGAAAAAGATCACAGACCAGGATACTCCTATCATCAGCGAGAAAACTATTGAGCACATTATCGAGCAGAAAACCAA
TATCCCTGTTGGTGATTTGAAAGAGAAAGAACAATCTCAACTCATCCATCTAGCCGAAGATCTCAAGTCTCATGTTATTG
GTCAAGATGATGCAGTCGATAAGATTGCCAAGGCTATTCGCCGTAATCGTGTCGGACTTGGTACCCCTAACCGCCCAATC
GGAAGCTTCCTCTTCGTTGGGCCAACTGGTGTCGGTAAGACAGAACTTTCCAAACAACTGGCTATCGAACTTTTTGGTTC
TGCTGATAGTATGATTCGCTTTGATATGAGTGAATACATGGAAAAACATAGTGTAGCTAAGTTGGTCGGCGCTCCTCCAG
GTTATGTTGGCTATGATGAGGCTGGTCAATTAACTGAAAAAGTTCGCCACAATCCATATTCTCTCATCCTTCTCGATGAA
GTGGAAAAAGCTCACCCAGATGTTATGCACATGTTTCTTCAAGTCTTGGACGATGGTCGTTTGACAGACGGGCAAGGACG
CACCGTTAGCTTCAAGGATGCCATCATTATCATGACCTCAAATGCAGGTACAGGAAAGACCGAAGCTAGCGTTGGATTTG
GTGCTACTAGAGAAGGACGTACCAATTCTGTCCTCGGTGAACTCGGTAACTTCTTTAGCCCAGAGTTTATGAACCGTTTT
GATGGCATTATCGAATTTAAGGCTCTCAGCAAGGATAACCTCCTTCAGATTGTCGAGCTCATGCTAGCAGATGTTAACAA
GCGCCTCTCTAGCAACAACATTCGTTTGGATGTAACTGACAAGGTCAAGGAAAAGTTGGTTGACCTAGGTTATGATCCAA
AAATGGGAGCACGCCCACTTCGTCGGACTATTCAAGACTATATTGAGGACACAATCACTGACTACTACCTTGAAAATCCA
AGCGAAAAAGATCTCAAAGCAGTTATGACTAGCAAGGGAAACATTCAGATTAAATCTGCCAAAAAAGCTGAAGTTAAAAG
TTCTGAAAAAGAAAAATAA

Domains

Predicted by InterproScan.

• AAA domain (Cdc48 subfamily) (AAA_2) (478-641)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (649-723)

• AAA lid domain (AAA_lid_9) (293-390)

• ATPase family associated with various cellular activities (AAA) (AAA) (155-276)

3D structure

• AlphaFold DB: A0A0B7M9N8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpE	Streptococcus pneumoniae Rx1	99.867	100	0.999
clpE	Streptococcus pneumoniae D39	99.867	100	0.999
clpE	Streptococcus pneumoniae R6	99.867	100	0.999
clpE	Streptococcus pneumoniae TIGR4	99.734	100	0.997
clpE	Streptococcus mutans UA159	82.731	99.335	0.822
clpC	Lactococcus lactis subsp. cremoris KW2	76.703	97.606	0.749
clpC	Bacillus subtilis subsp. subtilis str. 168	52.308	86.436	0.452
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	47.687	83.378	0.398
clpC	Streptococcus pneumoniae TIGR4	46.91	83.91	0.394
clpC	Streptococcus pneumoniae Rx1	46.91	83.91	0.394
clpC	Streptococcus pneumoniae D39	46.91	83.91	0.394
clpC	Streptococcus thermophilus LMD-9	46.795	82.979	0.388
clpC	Streptococcus thermophilus LMG 18311	46.4	83.112	0.386
clpC	Streptococcus mutans UA159	46.314	82.979	0.384