Detailed information NTG0338100

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: EQH23_RS09525
• Genome accession: NZ_CP035257
• Coordinates: 1872583..1873620 (-)
• Length: 345 a.a.
• NCBI ID: WP_000727284.1
• Uniprot ID: A0A380LR41
• Organism: Streptococcus pneumoniae strain TVO_1901928
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1867583..1878620

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH23_RS09500 (EQH23_10070)	-	1868322..1869653 (-)	1332	WP_000390042.1	hemolysin family protein	-
EQH23_RS09505 (EQH23_10075)	endA	1869944..1870768 (-)	825	WP_001036791.1	DNA-entry nuclease EndA	Machinery gene
EQH23_RS09510 (EQH23_10080)	-	1870807..1870995 (-)	189	WP_001036519.1	DNA-directed RNA polymerase subunit beta	-
EQH23_RS09515 (EQH23_10085)	murA	1870988..1872271 (-)	1284	WP_000358032.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
EQH23_RS09520 (EQH23_10090)	-	1872295..1872525 (-)	231	WP_000250390.1	DUF1146 family protein	-
EQH23_RS09525 (EQH23_10095)	sepM	1872583..1873620 (-)	1038	WP_000727284.1	SepM family pheromone-processing serine protease	Regulator
EQH23_RS09530 (EQH23_10100)	coaD	1873604..1874092 (-)	489	WP_001280746.1	pantetheine-phosphate adenylyltransferase	-
EQH23_RS09535 (EQH23_10105)	rsmD	1874082..1874621 (-)	540	WP_000706963.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
EQH23_RS09540 (EQH23_10110)	asnA	1874686..1875678 (-)	993	WP_000747993.1	aspartate--ammonia ligase	-
EQH23_RS09545 (EQH23_10120)	-	1875790..1876473 (-)	684	WP_001016913.1	Bax inhibitor-1/YccA family protein	-
EQH23_RS09550 (EQH23_10125)	-	1876529..1877269 (-)	741	WP_000152679.1	RNA methyltransferase	-
EQH23_RS09555 (EQH23_10130)	-	1877303..1877581 (+)	279	WP_001174614.1	acylphosphatase	-
EQH23_RS09560 (EQH23_10135)	yidC	1877659..1878585 (+)	927	WP_000835955.1	membrane protein insertase YidC	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37551.60 Da
• Isoelectric Point: 5.0772

>NTDB_id=338100 EQH23_RS09525 WP_000727284.1 1872583..1873620(-) (sepM) [Streptococcus pneumoniae strain TVO_1901928]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKEIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=338100 EQH23_RS09525 WP_000727284.1 1872583..1873620(-) (sepM) [Streptococcus pneumoniae strain TVO_1901928]
ATGAAAAAAAAGATTAGATGGCCTTTGTATGTCATTGCGGCCTTGATTGTGACCTTCTTGGCATTTGTGGTGCCTTTGCC
CTACTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCTACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGAAATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACAGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGACTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAGATTATCACCTTGGAAAATGGCAAAAATGGAATTGGAATCGGCTTGATTGACCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGTCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGTATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A380LR41

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.649	99.13	0.591