Detailed information NTG0337878

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: EQH28_RS11115
• Genome accession: NZ_CP035252
• Coordinates: 2159999..2160751 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866058.1
• Uniprot ID: A0AAX3HG98
• Organism: Streptococcus pneumoniae strain TVO_1901934
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2154999..2165751

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH28_RS11360 (EQH28_11695)	-	2157432..2159035 (-)	1604	Protein_2167	YhgE/Pip family protein	-
EQH28_RS11100 (EQH28_11700)	-	2159214..2159756 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
EQH28_RS11115 (EQH28_11715)	comE	2159999..2160751 (-)	753	WP_000866058.1	competence system response regulator transcription factor ComE	Regulator
EQH28_RS11120 (EQH28_11720)	comD/comD1	2160748..2162073 (-)	1326	WP_001813347.1	competence system sensor histidine kinase ComD	Regulator
EQH28_RS11125 (EQH28_11725)	comC/comC1	2162094..2162219 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
EQH28_RS11135 (EQH28_11735)	rlmH	2162502..2162981 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
EQH28_RS11140 (EQH28_11740)	htrA	2163164..2164345 (+)	1182	WP_000681601.1	S1C family serine protease	Regulator
EQH28_RS11145 (EQH28_11745)	spo0J	2164403..2165161 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29992.33 Da
• Isoelectric Point: 6.5073

>NTDB_id=337878 EQH28_RS11115 WP_000866058.1 2159999..2160751(-) (comE) [Streptococcus pneumoniae strain TVO_1901934]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQFIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=337878 EQH28_RS11115 WP_000866058.1 2159999..2160751(-) (comE) [Streptococcus pneumoniae strain TVO_1901934]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGTTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-121)

• LytTr DNA-binding domain (LytTR) (151-244)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	99.6	100	0.996
comE	Streptococcus pneumoniae D39	99.6	100	0.996
comE	Streptococcus pneumoniae R6	99.6	100	0.996
comE	Streptococcus pneumoniae TIGR4	99.6	100	0.996
comE	Streptococcus mitis SK321	98.8	100	0.988
comE	Streptococcus mitis NCTC 12261	98.8	100	0.988
comE	Streptococcus infantis strain Atu-4	91.6	100	0.916
comE/comE2	Streptococcus gordonii strain NCTC7865	63.2	100	0.632
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	63.2	100	0.632
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408