Detailed information NTG0337801

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: EQH29_RS10660
• Genome accession: NZ_CP035251
• Coordinates: 478430..479017 (-)
• Length: 195 a.a.
• NCBI ID: WP_000205166.1
• Uniprot ID: Q9ETN5
• Organism: Streptococcus pneumoniae strain TVO_1901935
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 473430..484017

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH29_RS02425 (EQH29_02570)	-	473892..475232 (+)	1341	WP_001017642.1	sensor histidine kinase	-
EQH29_RS02430 (EQH29_02575)	blpC	475303..475431 (-)	129	WP_000358815.1	quorum-sensing system pheromone BlpC	-
EQH29_RS02435 (EQH29_02580)	-	475488..476849 (-)	1362	WP_001069060.1	bacteriocin secretion accessory protein	-
EQH29_RS02440 (EQH29_02585)	comA/nlmT	476860..478536 (-)	1677	WP_196300924.1	peptide cleavage/export ABC transporter	Regulator
EQH29_RS10660	comA/nlmT	478430..479017 (-)	588	WP_000205166.1	cysteine peptidase family C39 domain-containing protein	Regulator
EQH29_RS02445 (EQH29_02590)	blpI	479299..479496 (+)	198	WP_001093259.1	bacteriocin-like peptide BlpI	-
EQH29_RS02450 (EQH29_02600)	blpJ	479963..480232 (+)	270	WP_001093248.1	bacteriocin-like peptide BlpJ	-
EQH29_RS02455 (EQH29_02605)	blpK	480301..480549 (+)	249	WP_047475057.1	bacteriocin-like peptide BlpK	-
EQH29_RS02460 (EQH29_02615)	cipB	480793..480942 (+)	150	WP_001809846.1	bacteriocin-like peptide BlpO	Regulator
EQH29_RS10775	-	480978..481043 (+)	66	Protein_490	ComC/BlpC family peptide pheromone/bacteriocin	-
EQH29_RS02465 (EQH29_02620)	-	481046..481165 (+)	120	WP_000346296.1	PncF family bacteriocin immunity protein	-
EQH29_RS02470 (EQH29_02630)	-	481646..482004 (+)	359	Protein_492	immunity protein	-
EQH29_RS02475 (EQH29_02640)	-	482633..483016 (+)	384	WP_000877381.1	hypothetical protein	-
EQH29_RS02480 (EQH29_02645)	-	483068..483757 (+)	690	WP_000760532.1	CPBP family intramembrane glutamic endopeptidase	-

Sequence

Protein

• Length: 195 a.a.
• Molecular weight: 22270.71 Da
• Isoelectric Point: 9.6188

>NTDB_id=337801 EQH29_RS10660 WP_000205166.1 478430..479017(-) (comA/nlmT) [Streptococcus pneumoniae strain TVO_1901935]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG

Nucleotide

• Length: 588 bp

>NTDB_id=337801 EQH29_RS10660 WP_000205166.1 478430..479017(-) (comA/nlmT) [Streptococcus pneumoniae strain TVO_1901935]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTT
CTTACTATCTCCAAGGAATCTTGGATGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: Q9ETN5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	59.89	93.333	0.559
comA	Streptococcus mitis NCTC 12261	54.891	94.359	0.518
comA	Streptococcus mitis SK321	54.348	94.359	0.513
comA	Streptococcus pneumoniae TIGR4	53.804	94.359	0.508
comA	Streptococcus pneumoniae Rx1	53.804	94.359	0.508
comA	Streptococcus pneumoniae D39	53.804	94.359	0.508
comA	Streptococcus pneumoniae R6	53.804	94.359	0.508
comA	Streptococcus gordonii str. Challis substr. CH1	52.717	94.359	0.497