Detailed information NTG0337699

Bioinformatically predicted

Overview

• Name: comX/comX2
• Type: Regulator
• Locus tag: EQH31_RS09760
• Genome accession: NZ_CP035249
• Coordinates: 1894510..1894989 (-)
• Length: 159 a.a.
• NCBI ID: WP_000588900.1
• Uniprot ID: A0A4J2BPQ8
• Organism: Streptococcus pneumoniae strain TVO_1901938
• Function: activate transcription of late competence genes (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IS/Tn	1893520..1894473	1894510..1894989	flank	37

Gene organization within MGE regions

Location: 1893520..1894989

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH31_RS09755 (EQH31_10365)	-	1893520..1894473 (+)	954	WP_001155321.1	IS30-like element ISSpn8 family transposase	-
EQH31_RS09760 (EQH31_10370)	comX/comX2	1894510..1894989 (-)	480	WP_000588900.1	sigma-70 family RNA polymerase sigma factor	Regulator

Sequence

Protein

• Length: 159 a.a.
• Molecular weight: 19899.55 Da
• Isoelectric Point: 7.3186

>NTDB_id=337699 EQH31_RS09760 WP_000588900.1 1894510..1894989(-) (comX/comX2) [Streptococcus pneumoniae strain TVO_1901938]
MIKELYEEVQGTVYKCRNEYYLHLWELSDWDQEGMLCLHELISREEGLVDDIPRLRKYFKTKFRNRILDYIRKQESQKRR
YDKEPYEEVGEISHRISEGGLWLDDYYLFHETLRDYRNKQSKEKQEELERVLSNERFRGRQRVLRDLRIVFKEFTIRTY

Nucleotide

• Length: 480 bp

>NTDB_id=337699 EQH31_RS09760 WP_000588900.1 1894510..1894989(-) (comX/comX2) [Streptococcus pneumoniae strain TVO_1901938]
ATGATTAAAGAATTGTATGAAGAAGTCCAAGGGACTGTGTATAAGTGTAGAAATGAATATTACCTTCATTTATGGGAATT
GTCGGATTGGGACCAAGAAGGCATGCTCTGCTTACATGAATTGATTAGTAGAGAAGAAGGACTGGTAGACGATATTCCAC
GTTTAAGGAAATATTTCAAAACCAAGTTTCGAAATCGAATTTTAGACTATATCCGTAAGCAGGAAAGTCAGAAGCGTAGA
TACGATAAAGAACCCTATGAAGAAGTGGGAGAGATCAGTCATCGTATAAGTGAGGGGGGTCTCTGGCTAGATGATTATTA
TCTCTTTCATGAAACACTAAGAGATTATAGAAACAAACAAAGTAAAGAGAAACAAGAAGAACTAGAACGCGTCTTAAGCA
ATGAACGATTTCGAGGGCGTCAAAGAGTATTAAGAGACTTACGCATTGTGTTTAAGGAGTTTACTATCCGTACCTACTAG

Domains

No domain identified.

3D structure

• AlphaFold DB: A0A4J2BPQ8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comX/comX2	Streptococcus pneumoniae Rx1	99.371	100	0.994
comX/comX1	Streptococcus pneumoniae Rx1	99.371	100	0.994
comX/comX2	Streptococcus pneumoniae D39	99.371	100	0.994
comX/comX1	Streptococcus pneumoniae D39	99.371	100	0.994
comX/comX2	Streptococcus pneumoniae R6	99.371	100	0.994
comX/comX1	Streptococcus pneumoniae R6	99.371	100	0.994
comX/comX2	Streptococcus pneumoniae TIGR4	98.742	100	0.987
comX/comX1	Streptococcus pneumoniae TIGR4	98.742	100	0.987
comX/sigX/comX1/sigX1	Streptococcus mitis NCTC 12261	91.824	100	0.918
comX/sigX/comX2/sigX2	Streptococcus mitis NCTC 12261	91.824	100	0.918
comX/sigX/comX2/sigX2	Streptococcus mitis SK321	91.139	99.371	0.906
comX/sigX/comX1/sigX1	Streptococcus mitis SK321	89.241	99.371	0.887
comR/comR2	Streptococcus gordonii str. Challis substr. CH1	48.718	98.113	0.478
comR/comR1	Streptococcus gordonii str. Challis substr. CH1	48.718	98.113	0.478
comX/sigX	Streptococcus mutans UA159	46	94.34	0.434
comX/sigX	Streptococcus suis isolate S10	45.695	94.969	0.434
comX/sigX	Streptococcus suis D9	45.695	94.969	0.434
comX/sigX	Streptococcus suis P1/7	45.695	94.969	0.434
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS315	39.216	96.226	0.377
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS315	39.216	96.226	0.377
comX/sigX/comX2/sigX2	Streptococcus pyogenes JRS4	40	94.34	0.377
comX/sigX/comX1/sigX1	Streptococcus pyogenes JRS4	40	94.34	0.377
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS8232	40	94.34	0.377
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS8232	40	94.34	0.377