Detailed information NTG0337618

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: EQH32_RS09180
• Genome accession: NZ_CP035248
• Coordinates: 1786155..1787192 (-)
• Length: 345 a.a.
• NCBI ID: WP_000727277.1
• Uniprot ID: A0A0B7LHQ0
• Organism: Streptococcus pneumoniae strain TVO_1901939
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1781155..1792192

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH32_RS09155 (EQH32_09640)	-	1781894..1783225 (-)	1332	WP_000390043.1	hemolysin family protein	-
EQH32_RS09160 (EQH32_09645)	endA	1783516..1784340 (-)	825	WP_001036790.1	DNA-entry nuclease EndA	Machinery gene
EQH32_RS09165 (EQH32_09650)	-	1784379..1784567 (-)	189	WP_001818955.1	DNA-directed RNA polymerase subunit beta	-
EQH32_RS09170 (EQH32_09655)	murA	1784560..1785843 (-)	1284	WP_000358023.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
EQH32_RS09175 (EQH32_09660)	-	1785867..1786097 (-)	231	WP_000250391.1	DUF1146 family protein	-
EQH32_RS09180 (EQH32_09665)	sepM	1786155..1787192 (-)	1038	WP_000727277.1	SepM family pheromone-processing serine protease	Regulator
EQH32_RS09185 (EQH32_09670)	coaD	1787176..1787664 (-)	489	WP_001280723.1	pantetheine-phosphate adenylyltransferase	-
EQH32_RS09190 (EQH32_09675)	rsmD	1787654..1788193 (-)	540	WP_000706964.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
EQH32_RS09195 (EQH32_09680)	asnA	1788258..1789250 (-)	993	WP_000747993.1	aspartate--ammonia ligase	-
EQH32_RS09200 (EQH32_09690)	-	1789361..1790044 (-)	684	WP_001016917.1	Bax inhibitor-1/YccA family protein	-
EQH32_RS09205 (EQH32_09695)	-	1790100..1790840 (-)	741	WP_000152678.1	RNA methyltransferase	-
EQH32_RS09210 (EQH32_09700)	-	1790874..1791152 (+)	279	WP_001174613.1	acylphosphatase	-
EQH32_RS09215 (EQH32_09705)	yidC	1791230..1792156 (+)	927	WP_000835941.1	membrane protein insertase YidC	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37537.57 Da
• Isoelectric Point: 5.0724

>NTDB_id=337618 EQH32_RS09180 WP_000727277.1 1786155..1787192(-) (sepM) [Streptococcus pneumoniae strain TVO_1901939]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=337618 EQH32_RS09180 WP_000727277.1 1786155..1787192(-) (sepM) [Streptococcus pneumoniae strain TVO_1901939]
ATGAAAAAAAAGATTAGATGGCCCTTATACGTCATTGCGGCCTTGATTGTGACTTTCTTGGCATTTGTAGTGCCCTTGCC
TTATTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCTACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACAGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGATTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGGAAGATTATCACCTTGGAAAATGGAAAAAATGGGATTGGAATCGGCTTGATTGATCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGCCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGTATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A0B7LHQ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.649	99.13	0.591