Detailed information NTG0337484

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: EQH34_RS10330
• Genome accession: NZ_CP035246
• Coordinates: 2045090..2045842 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain TVO_1901941
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2040090..2050842

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH34_RS10595	-	2042523..2044126 (-)	1604	Protein_2013	YhgE/Pip family protein	-
EQH34_RS10315 (EQH34_10905)	-	2044305..2044847 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
EQH34_RS10330 (EQH34_10920)	comE	2045090..2045842 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
EQH34_RS10335 (EQH34_10925)	comD/comD1	2045839..2047164 (-)	1326	WP_001850878.1	competence system sensor histidine kinase ComD	Regulator
EQH34_RS10340 (EQH34_10930)	comC/comC1	2047185..2047310 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
EQH34_RS10350 (EQH34_10940)	rlmH	2047592..2048071 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
EQH34_RS10355 (EQH34_10945)	htrA	2048254..2049435 (+)	1182	WP_000681597.1	S1C family serine protease	Regulator
EQH34_RS10360 (EQH34_10950)	spo0J	2049493..2050251 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=337484 EQH34_RS10330 WP_000866065.1 2045090..2045842(-) (comE) [Streptococcus pneumoniae strain TVO_1901941]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=337484 EQH34_RS10330 WP_000866065.1 2045090..2045842(-) (comE) [Streptococcus pneumoniae strain TVO_1901941]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTCTCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408