Detailed information NTG0337403

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: EQH35_RS10545
• Genome accession: NZ_CP035245
• Coordinates: 2033147..2033899 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain TVO_1901943
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2028147..2038899

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH35_RS10830 (EQH35_11105)	-	2030582..2032256 (-)	1675	Protein_2061	YhgE/Pip family protein	-
EQH35_RS10530 (EQH35_11110)	-	2032363..2032905 (+)	543	WP_001158255.1	TetR/AcrR family transcriptional regulator	-
EQH35_RS10545 (EQH35_11125)	comE	2033147..2033899 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
EQH35_RS10550 (EQH35_11130)	comD/comD1	2033896..2035221 (-)	1326	WP_014632435.1	competence system sensor histidine kinase ComD	Regulator
EQH35_RS10555 (EQH35_11135)	comC/comC1	2035242..2035367 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
EQH35_RS10565 (EQH35_11145)	rlmH	2035650..2036129 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
EQH35_RS10570 (EQH35_11150)	htrA	2036312..2037493 (+)	1182	WP_000681597.1	S1C family serine protease	Regulator
EQH35_RS10575 (EQH35_11155)	spo0J	2037551..2038309 (+)	759	WP_000410383.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=337403 EQH35_RS10545 WP_000866065.1 2033147..2033899(-) (comE) [Streptococcus pneumoniae strain TVO_1901943]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=337403 EQH35_RS10545 WP_000866065.1 2033147..2033899(-) (comE) [Streptococcus pneumoniae strain TVO_1901943]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAAC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTCTCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408