Detailed information    

insolico Bioinformatically predicted

Overview

Name   comEC/celB   Type   Machinery gene
Locus tag   EQH35_RS04480 Genome accession   NZ_CP035245
Coordinates   868892..871132 (+) Length   746 a.a.
NCBI ID   WP_000942414.1    Uniprot ID   A0A4J1ZQU0
Organism   Streptococcus pneumoniae strain TVO_1901943     
Function   ssDNA transport into the cell (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 863892..876132
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQH35_RS04450 (EQH35_04690) - 864043..865011 (+) 969 WP_000658183.1 PhoH family protein -
  EQH35_RS04455 (EQH35_04700) - 865204..865704 (+) 501 WP_000566982.1 GNAT family N-acetyltransferase -
  EQH35_RS04460 (EQH35_04705) - 865707..866032 (+) 326 Protein_897 TfoX/Sxy family protein -
  EQH35_RS04465 ald 866333..867444 (-) 1112 Protein_898 alanine dehydrogenase -
  EQH35_RS04470 (EQH35_04725) - 867621..868190 (+) 570 WP_238125046.1 GNAT family N-acetyltransferase -
  EQH35_RS04475 (EQH35_04730) comEA/celA/cilE 868258..868908 (+) 651 WP_000387335.1 helix-hairpin-helix domain-containing protein Machinery gene
  EQH35_RS04480 (EQH35_04735) comEC/celB 868892..871132 (+) 2241 WP_000942414.1 DNA internalization-related competence protein ComEC/Rec2 Machinery gene
  EQH35_RS04485 (EQH35_04740) - 871311..871499 (+) 189 WP_001809102.1 hypothetical protein -
  EQH35_RS04490 (EQH35_04745) - 871531..872118 (+) 588 WP_000933542.1 ATP-binding cassette domain-containing protein -
  EQH35_RS04495 (EQH35_04750) - 872122..873297 (+) 1176 WP_000655957.1 ABC transporter permease -
  EQH35_RS04500 (EQH35_04755) infC 873618..874148 (+) 531 WP_000848180.1 translation initiation factor IF-3 -
  EQH35_RS04505 (EQH35_04760) rpmI 874181..874381 (+) 201 WP_001125943.1 50S ribosomal protein L35 -
  EQH35_RS04510 (EQH35_04765) rplT 874433..874792 (+) 360 WP_000124836.1 50S ribosomal protein L20 -
  EQH35_RS04515 (EQH35_04770) - 874850..875230 (+) 381 WP_000157157.1 VOC family protein -

Sequence

Protein


Download         Length: 746 a.a.        Molecular weight: 84540.03 Da        Isoelectric Point: 9.6773

>NTDB_id=337354 EQH35_RS04480 WP_000942414.1 868892..871132(+) (comEC/celB) [Streptococcus pneumoniae strain TVO_1901943]
MLQWIKNFSIPLIYLSFLLLWLYYAIFSTSYLALLGFVFLLVCLFFQFPWKSASKVLVICGIFGFWFVFQNWQQSQASQN
LADSVERVRILPDTIKVNGDSLSFRGKSNGRAFQVYYKLQSEEEKEAFQALTDLHEIGLEGKLSEPEGQRNFGGFNYQAY
LKTQGIYQTLNIKTIQSLQKIGSWDIGENLSSLRRKAVVWIKTHFPDPMRNYMTGLLLGHLDTDFEEMNELYSSLGIIHL
FALSGMQVGFFMNGFKKLLLRLGLTQEKLKWLTYPFSLIYAGLTGFSASVIRSLLQKLLAQHGVKGLDNFALTVLVLFIV
MPNFFFTAGGVLSCAYAFILTMTSKEGEGLKAVASESLVISLGILPILSFYFAEFQPWSILLTFVFSFLFDLTFLPLLSI
LFVLSFLYPVIQLNFIFEWLEGIIRLVSQVARRPLVFGQPNAWLLILLLISLALVYDLRKNIKGLTVLSLLITGLFFLTK
YPLENEITMLDVGQGESIFLRDVTGKTILIDVGGKAESYKKIEKWQEKMTTSNAQRSLIPYLKSRGVAKIDQLILTNTDK
EHVGDLLEVTKAFHVGEILVSKGSLKQKQFVVELQATQTKVRSMTVGENLPIFGSQLEVLSPRKMGDGGHDDTLVLYGKF
LDKQFLFTGNLEEKGEKDLLKHYPDLKVNVLKASQHGSKKSSSPAFLEKLKPELTLISVGKSNRMKLPHQETLTRLEGIN
SKVYRTDQQGAIRFKGLDSWKIESVR

Nucleotide


Download         Length: 2241 bp        

>NTDB_id=337354 EQH35_RS04480 WP_000942414.1 868892..871132(+) (comEC/celB) [Streptococcus pneumoniae strain TVO_1901943]
ATGTTACAGTGGATTAAGAATTTCTCTATTCCCCTAATTTACCTGAGTTTTCTGTTACTTTGGCTTTACTACGCCATTTT
TTCAACATCCTATCTTGCTTTGTTGGGATTTGTTTTTCTGCTAGTCTGTCTCTTTTTCCAATTTCCTTGGAAATCTGCTA
GCAAAGTTCTAGTGATTTGTGGAATCTTTGGATTTTGGTTTGTTTTTCAAAATTGGCAACAGAGTCAAGCGAGTCAAAAT
CTGGCGGATTCTGTTGAAAGGGTACGGATTTTGCCTGATACTATTAAGGTTAATGGTGATAGTCTATCCTTTCGTGGCAA
GTCTAACGGTCGTGCTTTCCAAGTCTATTATAAACTCCAGTCCGAGGAGGAGAAAGAAGCCTTTCAAGCTTTAACCGACC
TGCATGAGATAGGACTAGAAGGGAAGCTTTCGGAGCCAGAAGGGCAGAGAAATTTTGGTGGCTTTAATTACCAAGCCTAT
CTGAAGACTCAGGGAATTTACCAGACTCTCAATATCAAAACAATCCAGTCACTTCAAAAGATTGGCAGTTGGGATATAGG
AGAAAACTTGTCCAGTTTACGTCGAAAGGCTGTGGTTTGGATTAAGACGCACTTTCCAGACCCTATGCGCAATTACATGA
CAGGACTCTTGCTGGGACATCTGGACACCGACTTTGAGGAGATGAATGAGCTTTATTCCAGTCTAGGAATTATCCACCTC
TTTGCCCTATCTGGCATGCAGGTAGGTTTTTTCATGAATGGATTTAAGAAACTTCTCTTGCGATTGGGCTTGACCCAAGA
AAAGTTGAAATGGCTGACTTATCCCTTTTCCCTTATCTATGCGGGACTAACTGGATTTTCAGCATCGGTTATTCGCAGTC
TCTTGCAAAAGCTACTGGCTCAACATGGGGTTAAGGGCTTGGATAATTTTGCCTTGACGGTGCTTGTCCTCTTTATTGTC
ATGCCAAACTTTTTCTTTACAGCAGGAGGAGTCTTGTCCTGCGCTTATGCTTTTATCCTGACCATGACCAGCAAAGAAGG
GGAGGGGCTCAAGGCTGTTGCTAGTGAAAGTCTAGTCATCTCCTTGGGCATATTGCCCATTCTATCCTTCTATTTTGCGG
AATTTCAACCTTGGTCTATCCTTTTGACCTTTGTCTTTTCCTTTCTATTTGACTTGACCTTCTTACCGCTCTTGTCTATT
TTATTTGTCCTTTCCTTTCTCTATCCAGTCATTCAGCTGAACTTTATCTTTGAATGGTTAGAGGGCATTATTCGCTTGGT
CTCGCAGGTGGCAAGGAGACCGCTTGTCTTTGGTCAACCCAACGCATGGCTTTTAATCTTATTGTTAATTTCCTTGGCTT
TGGTCTATGATTTGAGGAAAAACATTAAAGGATTAACAGTATTGAGTTTATTGATTACAGGTCTCTTTTTCCTTACCAAG
TATCCACTGGAAAATGAAATCACCATGCTGGATGTGGGGCAAGGAGAAAGTATTTTCCTACGGGATGTAACTGGGAAAAC
CATTCTCATAGATGTAGGTGGTAAGGCAGAATCTTATAAGAAAATCGAAAAATGGCAAGAAAAGATGACGACCAGCAATG
CACAGAGAAGCTTGATACCCTATCTTAAAAGTCGAGGAGTAGCTAAGATTGACCAGCTGATTTTGACAAATACGGACAAG
GAACATGTCGGAGATTTGTTAGAGGTGACCAAGGCTTTCCATGTAGGGGAGATTTTAGTATCAAAAGGCAGTTTGAAGCA
GAAGCAATTTGTGGTAGAACTACAGGCGACTCAAACAAAGGTGCGTAGTATGACAGTAGGGGAGAACTTGCCCATTTTTG
GAAGTCAGTTAGAAGTTCTATCTCCAAGGAAAATGGGAGATGGAGGACACGATGATACCCTAGTTCTGTATGGGAAATTC
TTGGATAAGCAATTTCTCTTCACGGGAAATTTGGAGGAGAAAGGAGAGAAGGACTTGCTGAAGCACTATCCAGACTTGAA
AGTAAATGTTTTGAAAGCTAGCCAACATGGCTCTAAAAAATCATCAAGTCCAGCCTTTCTAGAAAAACTCAAACCAGAGC
TTACTCTTATCTCAGTTGGAAAGAGCAATCGAATGAAACTCCCCCATCAGGAAACATTGACACGACTGGAAGGTATCAAT
AGCAAAGTTTATCGAACTGACCAGCAAGGAGCTATACGTTTTAAGGGGTTGGATAGTTGGAAAATCGAAAGTGTTCGATA
G

Domains

Predicted by InterproScan.

Domain of unknown function (DUF4131) (DUF4131)

(31-176)

Competence protein (Competence)

(216-458)

Metallo-beta-lactamase superfamily (Lactamase_B)

(492-697)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A4J1ZQU0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comEC/celB Streptococcus pneumoniae TIGR4

97.721

100

0.977
  comEC/celB Streptococcus pneumoniae Rx1

96.649

100

0.966
  comEC/celB Streptococcus pneumoniae D39

96.649

100

0.966
  comEC/celB Streptococcus pneumoniae R6

96.649

100

0.966
  comEC/celB Streptococcus mitis SK321

92.359

100

0.924
  comEC/celB Streptococcus mitis NCTC 12261

92.081

99.866

0.92
  comEC Lactococcus lactis subsp. cremoris KW2

44.534

99.33

0.442

Multiple sequence alignment