Detailed information NTG0337179

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: EQH38_RS10935
• Genome accession: NZ_CP035242
• Coordinates: 1789058..1789645 (+)
• Length: 195 a.a.
• NCBI ID: WP_000205166.1
• Uniprot ID: Q9ETN5
• Organism: Streptococcus pneumoniae strain TVO_1901947
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 1784058..1794645

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH38_RS09145 (EQH38_09630)	-	1784455..1785066 (-)	612	WP_000394045.1	CPBP family intramembrane glutamic endopeptidase	-
EQH38_RS09150 (EQH38_09640)	blpZ	1785217..1785450 (-)	234	WP_000276498.1	immunity protein BlpZ	-
EQH38_RS09155 (EQH38_09645)	-	1785492..1786181 (-)	690	WP_000760527.1	CPBP family intramembrane glutamic endopeptidase	-
EQH38_RS09160 (EQH38_09650)	-	1786233..1786616 (-)	384	WP_000877381.1	hypothetical protein	-
EQH38_RS09165 (EQH38_09660)	-	1787402..1787521 (-)	120	WP_000346296.1	PncF family bacteriocin immunity protein	-
EQH38_RS09170 (EQH38_09665)	cipB	1787625..1787774 (-)	150	WP_050095619.1	bacteriocin-like peptide BlpO	Regulator
EQH38_RS09175 (EQH38_09670)	blpJ	1787843..1788112 (-)	270	WP_001093248.1	bacteriocin-like peptide BlpJ	-
EQH38_RS09180 (EQH38_09680)	blpI	1788579..1788776 (-)	198	WP_001093259.1	bacteriocin-like peptide BlpI	-
EQH38_RS10935	comA/nlmT	1789058..1789645 (+)	588	WP_000205166.1	cysteine peptidase family C39 domain-containing protein	Regulator
EQH38_RS09185 (EQH38_09685)	comA/nlmT	1789572..1791215 (+)	1644	WP_078158894.1	peptide cleavage/export ABC transporter	Regulator
EQH38_RS09190 (EQH38_09690)	-	1791226..1792587 (+)	1362	WP_054366144.1	bacteriocin secretion accessory protein	-
EQH38_RS09195 (EQH38_09695)	blpC	1792644..1792772 (+)	129	WP_000358815.1	quorum-sensing system pheromone BlpC	-
EQH38_RS09200 (EQH38_09700)	-	1792843..1794183 (-)	1341	WP_001017646.1	sensor histidine kinase	-

Sequence

Protein

• Length: 195 a.a.
• Molecular weight: 22270.71 Da
• Isoelectric Point: 9.6188

>NTDB_id=337179 EQH38_RS10935 WP_000205166.1 1789058..1789645(+) (comA/nlmT) [Streptococcus pneumoniae strain TVO_1901947]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG

Nucleotide

• Length: 588 bp

>NTDB_id=337179 EQH38_RS10935 WP_000205166.1 1789058..1789645(+) (comA/nlmT) [Streptococcus pneumoniae strain TVO_1901947]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTT
CTTACTATCTCCAAGGAATCTTGGATGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: Q9ETN5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	59.89	93.333	0.559
comA	Streptococcus mitis NCTC 12261	54.891	94.359	0.518
comA	Streptococcus mitis SK321	54.348	94.359	0.513
comA	Streptococcus pneumoniae TIGR4	53.804	94.359	0.508
comA	Streptococcus pneumoniae Rx1	53.804	94.359	0.508
comA	Streptococcus pneumoniae D39	53.804	94.359	0.508
comA	Streptococcus pneumoniae R6	53.804	94.359	0.508
comA	Streptococcus gordonii str. Challis substr. CH1	52.717	94.359	0.497