Detailed information NTG0337160

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: EQH38_RS09205
• Genome accession: NZ_CP035242
• Coordinates: 1794197..1794934 (-)
• Length: 245 a.a.
• NCBI ID: WP_001219120.1
• Uniprot ID: Q9S1I6
• Organism: Streptococcus pneumoniae strain TVO_1901947
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1789197..1799934

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH38_RS09185 (EQH38_09685)	comA/nlmT	1789572..1791215 (+)	1644	WP_078158894.1	peptide cleavage/export ABC transporter	Regulator
EQH38_RS09190 (EQH38_09690)	-	1791226..1792587 (+)	1362	WP_054366144.1	bacteriocin secretion accessory protein	-
EQH38_RS09195 (EQH38_09695)	blpC	1792644..1792772 (+)	129	WP_000358815.1	quorum-sensing system pheromone BlpC	-
EQH38_RS09200 (EQH38_09700)	-	1792843..1794183 (-)	1341	WP_001017646.1	sensor histidine kinase	-
EQH38_RS09205 (EQH38_09705)	comE/blpR	1794197..1794934 (-)	738	WP_001219120.1	LytTR family DNA-binding domain-containing protein	Regulator
EQH38_RS09210 (EQH38_09710)	-	1794939..1795277 (-)	339	WP_000682120.1	LytTR family DNA-binding domain-containing protein	-
EQH38_RS09215 (EQH38_09715)	-	1795553..1795882 (+)	330	WP_000132567.1	hypothetical protein	-
EQH38_RS09220 (EQH38_09725)	-	1796050..1797099 (-)	1050	WP_000653773.1	ABC transporter permease	-
EQH38_RS09225 (EQH38_09730)	pptA	1797096..1797827 (-)	732	WP_000889921.1	ABC transporter ATP-binding protein	Regulator
EQH38_RS09230 (EQH38_09735)	-	1797895..1798305 (+)	411	WP_001278301.1	HIT family protein	-
EQH38_RS09235 (EQH38_09740)	-	1798315..1798602 (+)	288	WP_000777753.1	hypothetical protein	-
EQH38_RS09240 (EQH38_09745)	-	1798764..1798958 (+)	195	WP_001808905.1	hypothetical protein	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28754.98 Da
• Isoelectric Point: 6.5884

>NTDB_id=337160 EQH38_RS09205 WP_001219120.1 1794197..1794934(-) (comE/blpR) [Streptococcus pneumoniae strain TVO_1901947]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INKLH

Nucleotide

• Length: 738 bp

>NTDB_id=337160 EQH38_RS09205 WP_001219120.1 1794197..1794934(-) (comE/blpR) [Streptococcus pneumoniae strain TVO_1901947]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCC
ATCAATAAATTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: Q9S1I6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.321	99.184	0.539
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.017	98.776	0.376
comE	Streptococcus infantis strain Atu-4	35.887	100	0.363