Detailed information NTG0337102

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: EQH39_RS10265
• Genome accession: NZ_CP035241
• Coordinates: 458163..458750 (-)
• Length: 195 a.a.
• NCBI ID: WP_000205166.1
• Uniprot ID: Q9ETN5
• Organism: Streptococcus pneumoniae strain TVO_1901948
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 453163..463750

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH39_RS02255 (EQH39_02375)	-	453624..454964 (+)	1341	WP_001028654.1	sensor histidine kinase	-
EQH39_RS02260 (EQH39_02380)	blpC	455009..455164 (-)	156	WP_000358810.1	quorum-sensing system pheromone BlpC	-
EQH39_RS02265 (EQH39_02385)	-	455221..456582 (-)	1362	WP_001069085.1	bacteriocin secretion accessory protein	-
EQH39_RS02270 (EQH39_02390)	comA/nlmT	456593..458269 (-)	1677	WP_307774231.1	peptide cleavage/export ABC transporter	Regulator
EQH39_RS10265	comA/nlmT	458163..458750 (-)	588	WP_000205166.1	cysteine peptidase family C39 domain-containing protein	Regulator
EQH39_RS02275 (EQH39_02395)	blpI	459041..459238 (+)	198	WP_001093259.1	bacteriocin-like peptide BlpI	-
EQH39_RS02280 (EQH39_02405)	blpJ	459705..459974 (+)	270	WP_001093248.1	bacteriocin-like peptide BlpJ	-
EQH39_RS02285 (EQH39_02410)	blpU	460043..460273 (+)	231	WP_000379964.1	bacteriocin-like peptide BlpU	-
EQH39_RS02290 (EQH39_02415)	-	460276..460395 (+)	120	WP_000346298.1	PncF family bacteriocin immunity protein	-
EQH39_RS02295 (EQH39_02420)	-	460692..460853 (+)	162	WP_000727119.1	hypothetical protein	-
EQH39_RS02300 (EQH39_02425)	-	460876..461234 (+)	359	Protein_455	immunity protein	-
EQH39_RS02305 (EQH39_02435)	-	461863..462246 (+)	384	WP_000877381.1	hypothetical protein	-
EQH39_RS02310 (EQH39_02440)	-	462298..462987 (+)	690	WP_000760514.1	CPBP family intramembrane glutamic endopeptidase	-
EQH39_RS02315 (EQH39_02445)	blpZ	463029..463262 (+)	234	WP_000276498.1	immunity protein BlpZ	-

Sequence

Protein

• Length: 195 a.a.
• Molecular weight: 22270.71 Da
• Isoelectric Point: 9.6188

>NTDB_id=337102 EQH39_RS10265 WP_000205166.1 458163..458750(-) (comA/nlmT) [Streptococcus pneumoniae strain TVO_1901948]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG

Nucleotide

• Length: 588 bp

>NTDB_id=337102 EQH39_RS10265 WP_000205166.1 458163..458750(-) (comA/nlmT) [Streptococcus pneumoniae strain TVO_1901948]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTT
CTTACTATCTCCAAGGAATCTTGGATGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: Q9ETN5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	59.89	93.333	0.559
comA	Streptococcus mitis NCTC 12261	54.891	94.359	0.518
comA	Streptococcus mitis SK321	54.348	94.359	0.513
comA	Streptococcus pneumoniae TIGR4	53.804	94.359	0.508
comA	Streptococcus pneumoniae Rx1	53.804	94.359	0.508
comA	Streptococcus pneumoniae D39	53.804	94.359	0.508
comA	Streptococcus pneumoniae R6	53.804	94.359	0.508
comA	Streptococcus gordonii str. Challis substr. CH1	52.717	94.359	0.497