Detailed information NTG0337077

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: EQH39_RS08700
• Genome accession: NZ_CP035241
• Coordinates: 1718950..1719987 (-)
• Length: 345 a.a.
• NCBI ID: WP_000727277.1
• Uniprot ID: A0A0B7LHQ0
• Organism: Streptococcus pneumoniae strain TVO_1901948
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1713950..1724987

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH39_RS08675 (EQH39_09140)	-	1714689..1716020 (-)	1332	WP_000390042.1	hemolysin family protein	-
EQH39_RS08680 (EQH39_09145)	endA	1716311..1717135 (-)	825	WP_001036781.1	DNA-entry nuclease EndA	Machinery gene
EQH39_RS08685 (EQH39_09150)	-	1717174..1717362 (-)	189	WP_001036519.1	DNA-directed RNA polymerase subunit beta	-
EQH39_RS08690 (EQH39_09155)	murA	1717355..1718638 (-)	1284	WP_000358028.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
EQH39_RS08695 (EQH39_09160)	-	1718662..1718892 (-)	231	WP_000250384.1	DUF1146 family protein	-
EQH39_RS08700 (EQH39_09165)	sepM	1718950..1719987 (-)	1038	WP_000727277.1	SepM family pheromone-processing serine protease	Regulator
EQH39_RS08705 (EQH39_09170)	coaD	1719971..1720459 (-)	489	WP_001280769.1	pantetheine-phosphate adenylyltransferase	-
EQH39_RS08710 (EQH39_09175)	rsmD	1720449..1720988 (-)	540	WP_000706960.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
EQH39_RS08715 (EQH39_09180)	asnA	1721053..1722045 (-)	993	WP_000747993.1	aspartate--ammonia ligase	-
EQH39_RS08720 (EQH39_09190)	-	1722156..1722839 (-)	684	WP_001016917.1	Bax inhibitor-1/YccA family protein	-
EQH39_RS08725 (EQH39_09195)	-	1722895..1723635 (-)	741	WP_000152680.1	RNA methyltransferase	-
EQH39_RS08730 (EQH39_09200)	-	1723669..1723947 (+)	279	WP_001174613.1	acylphosphatase	-
EQH39_RS08735 (EQH39_09205)	yidC	1724025..1724951 (+)	927	WP_000835941.1	membrane protein insertase YidC	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37537.57 Da
• Isoelectric Point: 5.0724

>NTDB_id=337077 EQH39_RS08700 WP_000727277.1 1718950..1719987(-) (sepM) [Streptococcus pneumoniae strain TVO_1901948]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=337077 EQH39_RS08700 WP_000727277.1 1718950..1719987(-) (sepM) [Streptococcus pneumoniae strain TVO_1901948]
ATGAAAAAAAAGATTAGATGGCCCTTATACGTCATTGCGGCCTTGATTGTGACTTTCTTGGCATTTGTAGTGCCCTTGCC
TTATTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCCACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACAGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGATTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAAATCATCACCTTGGAAAATGGCAAAAATGGAATTGGAATCGGCTTGATTGACCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGTCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGTATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A0B7LHQ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.649	99.13	0.591