Detailed information NTG0336918

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: EQH42_RS08890
• Genome accession: NZ_CP035238
• Coordinates: 1764510..1765547 (-)
• Length: 345 a.a.
• NCBI ID: WP_000727277.1
• Uniprot ID: A0A0B7LHQ0
• Organism: Streptococcus pneumoniae strain TVO_D39
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1759510..1770547

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH42_RS08865 (EQH42_09380)	-	1760311..1761642 (-)	1332	WP_000390046.1	hemolysin family protein	-
EQH42_RS08870 (EQH42_09385)	endA	1761871..1762695 (-)	825	WP_001036779.1	DNA-entry nuclease EndA	Machinery gene
EQH42_RS08875 (EQH42_09390)	-	1762734..1762922 (-)	189	WP_001036519.1	DNA-directed RNA polymerase subunit beta	-
EQH42_RS08880 (EQH42_09395)	murA	1762915..1764198 (-)	1284	WP_000358027.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
EQH42_RS08885 (EQH42_09400)	-	1764222..1764452 (-)	231	WP_000250384.1	DUF1146 family protein	-
EQH42_RS08890 (EQH42_09405)	sepM	1764510..1765547 (-)	1038	WP_000727277.1	SepM family pheromone-processing serine protease	Regulator
EQH42_RS08895 (EQH42_09410)	coaD	1765531..1766019 (-)	489	WP_001280727.1	pantetheine-phosphate adenylyltransferase	-
EQH42_RS08900 (EQH42_09415)	rsmD	1766009..1766548 (-)	540	WP_000706962.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
EQH42_RS08905 (EQH42_09420)	asnA	1766613..1767605 (-)	993	WP_000747995.1	aspartate--ammonia ligase	-
EQH42_RS08910 (EQH42_09430)	-	1767717..1768400 (-)	684	WP_001016917.1	Bax inhibitor-1/YccA family protein	-
EQH42_RS08915 (EQH42_09435)	-	1768456..1769196 (-)	741	WP_000152673.1	RNA methyltransferase	-
EQH42_RS08920 (EQH42_09440)	-	1769230..1769508 (+)	279	WP_001174613.1	acylphosphatase	-
EQH42_RS08925 (EQH42_09445)	yidC	1769586..1770512 (+)	927	WP_000835947.1	membrane protein insertase YidC	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37537.57 Da
• Isoelectric Point: 5.0724

>NTDB_id=336918 EQH42_RS08890 WP_000727277.1 1764510..1765547(-) (sepM) [Streptococcus pneumoniae strain TVO_D39]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=336918 EQH42_RS08890 WP_000727277.1 1764510..1765547(-) (sepM) [Streptococcus pneumoniae strain TVO_D39]
ATGAAAAAAAAGATTAGATGGCCCTTATACGTCATTGCGGCCTTGATTGTGACTTTCTTGGCATTTGTAGTGCCCTTGCC
TTATTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCCACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACAGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGATTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAGATTATCACCTTGGAAAATGGCAAAAATGGAATTGGAATCGGCTTGATTGATCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGCCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGCATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A0B7LHQ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.649	99.13	0.591