Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   EQH42_RS06065 Genome accession   NZ_CP035238
Coordinates   1225136..1225873 (-) Length   245 a.a.
NCBI ID   WP_000782664.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain TVO_D39     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 1220136..1230873
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQH42_RS06045 (EQH42_06375) msrB 1221594..1222532 (-) 939 WP_000818207.1 peptide-methionine (R)-S-oxide reductase MsrB -
  EQH42_RS06050 (EQH42_06380) - 1222561..1222752 (-) 192 WP_000693310.1 hypothetical protein -
  EQH42_RS06055 (EQH42_06385) thrB 1222828..1223697 (-) 870 WP_000692438.1 homoserine kinase -
  EQH42_RS06060 (EQH42_06390) - 1223699..1224985 (-) 1287 WP_000216382.1 homoserine dehydrogenase -
  EQH42_RS06065 (EQH42_06395) mecA 1225136..1225873 (-) 738 WP_000782664.1 adaptor protein MecA Regulator
  EQH42_RS06070 (EQH42_06400) - 1226015..1227049 (-) 1035 WP_000461498.1 hypothetical protein -
  EQH42_RS06075 (EQH42_06405) - 1227078..1228511 (-) 1434 WP_000565088.1 O-antigen polysaccharide polymerase Wzy family protein -
  EQH42_RS06080 (EQH42_06410) - 1228527..1229513 (-) 987 WP_000446981.1 glycosyltransferase family 2 protein -
  EQH42_RS06085 (EQH42_06415) - 1229515..1230618 (-) 1104 WP_000225896.1 glycosyltransferase -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28363.15 Da        Isoelectric Point: 4.0199

>NTDB_id=336895 EQH42_RS06065 WP_000782664.1 1225136..1225873(-) (mecA) [Streptococcus pneumoniae strain TVO_D39]
MKMKQISDTTLKITISLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQAEQEAESKKEPYIYYILSFA
KLADLVAFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFADDSDISRSVLQEYGQVLMSHDAVLN
LQKIG

Nucleotide


Download         Length: 738 bp        

>NTDB_id=336895 EQH42_RS06065 WP_000782664.1 1225136..1225873(-) (mecA) [Streptococcus pneumoniae strain TVO_D39]
ATGAAAATGAAACAAATTAGTGATACAACTTTAAAAATCACGATATCTTTAGAGGATTTGATGGATCGTGGAATGGAGAT
TGCTGACTTTCTCGTTCCTCAAGAAAAAACAGAAGAGTTCTTTTATGCTATCTTGGATGAGCTAGAGATGCCTGATAGCT
TTCTGGATACAGGCATGTTGAGCTTCCGTGTGACTCCAAAACCTGATAAGGTAGATGTCTTTGTGACCAAGTCAAAGATT
GACCAAAATCTAGATTTTGAAGACTTATCGGATTTGCCAGATATGGAAGAATTGGCTCAAATGTCTCCAGATGAATTTAT
CAAAACCCTGGAAAAAAGCATCGCAGACAAAACCAAGGATGATATCGAAGCCATTCAATCTCTTGAGCAAGTTGAAGCCA
AGGAAGAAGAGCAAGAGCAGGCTGAACAAGAAGCTGAGAGTAAGAAAGAACCTTACATCTACTACATCCTTTCTTTTGCT
AAGTTGGCTGACTTGGTAGCTTTTGCCAAGACAGTGACTTTTGAAATGGAAACTTCTGAACTCTACAAAATGAACGAGCG
CTATTATTTGACCATTTTAGTGGATATTGAAAATCATCCAAGCCCATATCCAGCTTGGCTGTTGGCCCGTATGCGCGAGT
TTGCAGACGATAGTGATATCAGTCGCTCAGTCTTACAAGAGTATGGTCAAGTCTTGATGAGTCACGATGCAGTGCTCAAT
CTGCAAAAAATCGGCTAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

100

100

1
  mecA Streptococcus pneumoniae D39

100

100

1
  mecA Streptococcus pneumoniae R6

100

100

1
  mecA Streptococcus pneumoniae TIGR4

99.592

100

0.996
  mecA Streptococcus thermophilus LMD-9

48.193

100

0.49
  mecA Streptococcus thermophilus LMG 18311

47.791

100

0.486
  mecA Streptococcus mutans UA159

48.571

100

0.486

Multiple sequence alignment