Detailed information NTG0336767

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: EQH44_RS09155
• Genome accession: NZ_CP035236
• Coordinates: 1813397..1814434 (-)
• Length: 345 a.a.
• NCBI ID: WP_000727277.1
• Uniprot ID: A0A0B7LHQ0
• Organism: Streptococcus pneumoniae strain TVO_1902282
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1808397..1819434

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH44_RS09130 (EQH44_09655)	-	1809198..1810529 (-)	1332	WP_000390047.1	hemolysin family protein	-
EQH44_RS09135 (EQH44_09660)	endA	1810758..1811582 (-)	825	WP_001036779.1	DNA-entry nuclease EndA	Machinery gene
EQH44_RS09140 (EQH44_09665)	-	1811621..1811809 (-)	189	WP_001036519.1	DNA-directed RNA polymerase subunit beta	-
EQH44_RS09145 (EQH44_09670)	murA	1811802..1813085 (-)	1284	WP_000358028.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
EQH44_RS09150 (EQH44_09675)	-	1813109..1813339 (-)	231	WP_000250384.1	DUF1146 family protein	-
EQH44_RS09155 (EQH44_09680)	sepM	1813397..1814434 (-)	1038	WP_000727277.1	SepM family pheromone-processing serine protease	Regulator
EQH44_RS09160 (EQH44_09685)	coaD	1814418..1814906 (-)	489	WP_001280742.1	pantetheine-phosphate adenylyltransferase	-
EQH44_RS09165 (EQH44_09690)	rsmD	1814896..1815435 (-)	540	WP_000706962.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
EQH44_RS09170 (EQH44_09695)	asnA	1815500..1816492 (-)	993	WP_000747993.1	aspartate--ammonia ligase	-
EQH44_RS09175 (EQH44_09705)	-	1816603..1817286 (-)	684	WP_001016916.1	Bax inhibitor-1/YccA family protein	-
EQH44_RS09180 (EQH44_09710)	-	1817342..1818082 (-)	741	WP_000152702.1	RNA methyltransferase	-
EQH44_RS09185 (EQH44_09715)	-	1818116..1818394 (+)	279	WP_001174613.1	acylphosphatase	-
EQH44_RS09190 (EQH44_09720)	yidC	1818472..1819398 (+)	927	WP_000835948.1	membrane protein insertase YidC	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37537.57 Da
• Isoelectric Point: 5.0724

>NTDB_id=336767 EQH44_RS09155 WP_000727277.1 1813397..1814434(-) (sepM) [Streptococcus pneumoniae strain TVO_1902282]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=336767 EQH44_RS09155 WP_000727277.1 1813397..1814434(-) (sepM) [Streptococcus pneumoniae strain TVO_1902282]
ATGAAAAAAAAGATTAGATGGCCCTTATACGTCATTGCGGCCTTGATTGTGACTTTCTTGGCATTTGTAGTGCCCTTGCC
TTATTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCCACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACAGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGATTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAAATCATCACCTTGGAAAATGGCAAAAATGGAATTGGAATCGGCTTGATTGACCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGTCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGTATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A0B7LHQ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.649	99.13	0.591