Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   EQH45_RS06750 Genome accession   NZ_CP035235
Coordinates   1348442..1349116 (-) Length   224 a.a.
NCBI ID   WP_000590637.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain TVO_1902276     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1343442..1354116
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQH45_RS06735 (EQH45_07075) - 1345728..1346657 (-) 930 WP_000411851.1 peptidase U32 family protein -
  EQH45_RS06740 (EQH45_07080) - 1346797..1347084 (+) 288 WP_001145225.1 DUF3270 domain-containing protein -
  EQH45_RS06745 (EQH45_07085) ciaH 1347118..1348452 (-) 1335 WP_000491790.1 two-component system sensor histidine kinase CiaH Regulator
  EQH45_RS06750 (EQH45_07090) ciaR 1348442..1349116 (-) 675 WP_000590637.1 two-component system response regulator CiaR Regulator
  EQH45_RS06755 (EQH45_07095) - 1349225..1351771 (-) 2547 WP_001149118.1 M1 family metallopeptidase -
  EQH45_RS06760 (EQH45_07100) - 1351894..1352334 (-) 441 WP_000612883.1 ASCH domain-containing protein -
  EQH45_RS06765 (EQH45_07105) - 1352309..1353178 (-) 870 WP_001245821.1 putative PEP-binding protein -
  EQH45_RS06770 (EQH45_07110) - 1353156..1353656 (-) 501 WP_000403351.1 NUDIX hydrolase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25480.32 Da        Isoelectric Point: 4.3283

>NTDB_id=336668 EQH45_RS06750 WP_000590637.1 1348442..1349116(-) (ciaR) [Streptococcus pneumoniae strain TVO_1902276]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGNIVVNLSTNTVKVEDTPVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYISKVRKKLKGTTFAENLQTLRSVGYLLKDVQ

Nucleotide


Download         Length: 675 bp        

>NTDB_id=336668 EQH45_RS06750 WP_000590637.1 1348442..1349116(-) (ciaR) [Streptococcus pneumoniae strain TVO_1902276]
ATGATAAAAATCTTATTGGTTGAGGATGACCTAGGTCTGTCAAATTCAGTATTTGACTTTTTAGACGATTTTGCGGATGT
TATGCAGGTATTTGATGGAGAAGAAGGTCTCTACGAAGCTGAGAGTGGTGTCTATGACTTGATTTTGCTGGATTTGATGT
TGCCAGAAAAAAATGGTTTCCAAGTCTTAAAAGAATTGCGTGAAAAGGGAATTACGACACCAGTTCTGATTATGACTGCC
AAGGAAAGTTTGGATGACAAGGGACATGGATTTGAACTGGGAGCGGATGATTATCTGACCAAACCTTTCTACCTAGAAGA
ACTTAAAATGCGGATTCAGGCTCTTCTCAAACGTTCAGGGAAGTTTAATGAAAACACCTTGACTTATGGGAATATCGTGG
TTAATTTATCAACCAATACCGTTAAAGTTGAAGATACTCCTGTCGAATTGCTGGGGAAAGAGTTCGATTTACTAGTTTAT
TTCCTTCAAAATCAAAATGTGATTTTACCTAAGACGCAGATTTTTGACCGTCTATGGGGATTTGATAGTGATACAACGAT
TTCGGTTGTCGAAGTCTATATTTCAAAAGTCCGTAAGAAATTAAAGGGAACCACTTTTGCAGAGAATTTGCAAACTTTGC
GTAGTGTTGGGTATCTTTTAAAAGATGTTCAGTAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

99.554

100

0.996
  ciaR Streptococcus pneumoniae D39

99.554

100

0.996
  ciaR Streptococcus pneumoniae R6

99.554

100

0.996
  ciaR Streptococcus pneumoniae TIGR4

99.554

100

0.996
  ciaR Streptococcus mutans UA159

87.946

100

0.879
  covR Lactococcus lactis subsp. lactis strain DGCC12653

37.168

100

0.375
  vicR Streptococcus mutans UA159

35.193

100

0.366

Multiple sequence alignment