Detailed information NTG0033512

Bioinformatically predicted

Overview

• Name: clpE
• Type: Regulator
• Locus tag: SEQ_RS03100
• Genome accession: NC_012471
• Coordinates: 613408..615660 (-)
• Length: 750 a.a.
• NCBI ID: WP_012679176.1
• Uniprot ID: C0M7F6
• Organism: Streptococcus equi subsp. equi 4047
• Function: repress competence development (at the early growth phase) (predicted from homology) Competence regulation

Genomic Context

Location: 608408..620660

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SEQ_RS03085 (SEQ_0627)	ileS	609159..611957 (+)	2799	WP_012679174.1	isoleucine--tRNA ligase	-
SEQ_RS03090 (SEQ_0628)	-	612435..612737 (-)	303	WP_012515246.1	DUF1827 family protein	-
SEQ_RS03095 (SEQ_0629)	-	612799..613248 (-)	450	WP_012679175.1	NUDIX hydrolase	-
SEQ_RS03100 (SEQ_0630)	clpE	613408..615660 (-)	2253	WP_012679176.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
SEQ_RS03105 (SEQ_0631)	-	615942..616172 (+)	231	WP_012515249.1	DUF1797 family protein	-
SEQ_RS03110 (SEQ_0633)	-	616654..617592 (-)	939	WP_012679177.1	LPXTG cell wall anchor domain-containing protein	-
SEQ_RS03115 (SEQ_0634)	-	617934..618617 (+)	684	WP_012679178.1	amino acid ABC transporter permease	-
SEQ_RS03120 (SEQ_0635)	-	618619..619356 (+)	738	WP_012679179.1	amino acid ABC transporter ATP-binding protein	-

Sequence

Protein

• Length: 750 a.a.
• Molecular weight: 83868.33 Da
• Isoelectric Point: 5.7574

>NTDB_id=33512 SEQ_RS03100 WP_012679176.1 613408..615660(-) (clpE) [Streptococcus equi subsp. equi 4047]
MLCQNCNLNESTIHLYTSINGKQRQIDLCQNCYQIMKTDPKNPILGGYNGNQKAQQPSQNPFFDDFFGDLNNFRAFGQLP
NTPPTQSGGHNGGGHNGYRPNHTQPAQEANKGLLEEFGINITEMAKRGDIDPVIGRDDEIIRVIEILNRRTKNNPVLIGE
PGVGKTAVVEGLAQKIVDGDVPQKLQSKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRKRHDVILFIDEIHEIVGAGA
VGDGSMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPSVEETITILKGIQPKYEDYHHVKYSQS
AIEAAANLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKDIDKRLIEAENLKTQATRDEDYERAAYFRDQIAKYKE
MQAQKLDEQDIPIITDKTIEAIVEQKTNIPVGDLKEKEQSQLVNLAADLKKHVIGQDDAVDKIAKAIRRNRVGLGVPNRP
IGSFLFVGPTGVGKTELSKQLAIELFGSADNMIRFDMSEYMEKHAVAKLVGAPPGYVGYEEAGQLTEQVRRNPYSLILLD
EIEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKTEASVGFGAAREGRTNSVLGELSHFFSPEFMNR
FDGIIEFQPLSKDNLLHIVHLMLDDVNHRLAHNNIRLDVTQKVKEKLVELGYDPKMGARPLRRTIQDYIEDAITDFYLEH
PAEKDMRAVLTSNGHIIIKPVVKSQAKQAD

Nucleotide

• Length: 2253 bp

>NTDB_id=33512 SEQ_RS03100 WP_012679176.1 613408..615660(-) (clpE) [Streptococcus equi subsp. equi 4047]
ATGCTTTGTCAAAACTGTAATTTAAACGAATCAACCATTCATCTTTATACAAGCATTAACGGAAAGCAAAGGCAGATTGA
CCTCTGTCAAAATTGCTACCAAATCATGAAAACAGACCCTAAAAATCCTATCTTAGGAGGCTATAATGGCAACCAAAAGG
CGCAGCAGCCTTCTCAAAACCCTTTCTTTGATGACTTTTTTGGTGACCTGAACAATTTTAGAGCCTTCGGTCAATTGCCC
AATACACCACCTACCCAATCAGGCGGCCATAATGGCGGAGGTCACAATGGCTACCGTCCCAATCACACACAGCCAGCACA
AGAGGCTAACAAAGGTTTGCTTGAGGAATTCGGCATTAATATCACTGAAATGGCTAAGCGTGGTGATATTGATCCTGTCA
TCGGACGTGACGATGAGATTATCCGCGTGATCGAGATTCTCAACCGTCGTACCAAAAATAACCCTGTCCTAATCGGAGAA
CCAGGTGTTGGTAAGACTGCTGTCGTTGAAGGCCTTGCTCAAAAAATCGTTGATGGCGATGTGCCACAAAAGCTACAGAG
TAAGCAGGTGATTCGCCTTGATGTGGTTAGCCTCGTTCAGGGGACAGGTATTCGTGGCCAATTTGAAGAGCGCATGCAAA
AGCTCATGGAGGAAATCCGCAAGCGCCATGACGTGATTCTATTTATTGATGAAATCCATGAAATTGTGGGAGCTGGTGCA
GTTGGTGACGGCAGCATGGACGCAGGAAATATTTTAAAGCCAGCACTTGCTCGTGGTGAGCTTCAATTAGTGGGAGCGAC
CACTCTCAATGAATATCGCATCATCGAAAAGGACGCAGCCCTTGAGCGACGCATGCAGCCGGTTAAGGTGGACGAGCCTT
CGGTTGAAGAAACAATCACTATCCTAAAAGGAATCCAACCCAAATATGAGGACTATCACCATGTCAAATATAGCCAGTCG
GCTATTGAAGCAGCTGCTAACCTCTCCAACCGCTATATTCAAGACCGCTTCTTGCCTGATAAGGCCATTGACCTGCTAGA
TGAAGCCGGCTCAAAGATGAACCTAACCCTTAACTTTGTTGACCCCAAAGACATTGATAAGCGTTTGATTGAGGCTGAAA
ACCTCAAGACACAAGCCACACGTGATGAGGATTATGAGCGAGCAGCCTATTTCCGCGATCAAATCGCCAAATATAAAGAA
ATGCAGGCTCAAAAGCTAGATGAGCAGGATATTCCAATCATCACTGACAAGACCATCGAAGCAATCGTTGAGCAAAAAAC
CAATATTCCAGTTGGTGATTTAAAGGAAAAGGAACAATCACAGCTAGTCAATCTGGCCGCCGATCTCAAAAAGCATGTTA
TCGGTCAAGACGATGCTGTTGATAAAATTGCAAAAGCTATCCGTCGTAATCGTGTTGGACTGGGAGTCCCAAATCGTCCT
ATCGGCTCCTTCCTCTTTGTTGGCCCAACTGGTGTCGGTAAAACAGAGCTTTCCAAGCAATTAGCCATTGAGCTTTTTGG
CTCTGCTGATAACATGATTCGCTTTGACATGTCTGAATACATGGAAAAGCACGCTGTGGCTAAGCTTGTCGGTGCCCCTC
CCGGCTACGTCGGCTATGAGGAGGCAGGTCAGTTAACAGAGCAGGTGCGCCGCAACCCTTACTCGCTCATTTTGTTAGAT
GAGATCGAAAAGGCTCACCCTGATGTCATGCACATGTTTTTACAGGTCCTAGATGACGGACGATTAACCGACGGACAAGG
ACGTACCGTTAGCTTTAAGGACACTATTATCATCATGACATCAAATGCTGGCACTGGCAAAACAGAGGCCTCAGTAGGCT
TTGGCGCTGCTAGAGAAGGGCGGACAAACTCTGTTTTAGGAGAGCTCAGTCATTTCTTTAGCCCCGAGTTCATGAATCGC
TTTGATGGCATTATTGAGTTTCAGCCACTAAGCAAGGACAATCTTTTACATATCGTTCATTTAATGCTCGATGATGTTAA
CCACCGCCTTGCTCACAATAACATTCGCCTTGATGTCACCCAAAAGGTCAAAGAAAAGCTCGTTGAGCTAGGCTATGATC
CTAAGATGGGAGCACGACCATTGCGCCGCACCATTCAGGACTACATTGAGGACGCCATTACTGACTTCTACCTTGAGCAC
CCAGCAGAAAAAGACATGCGAGCTGTCTTGACCTCTAATGGACACATTATAATCAAGCCTGTAGTCAAATCTCAGGCGAA
GCAGGCGGACTAA

Domains

Predicted by InterproScan.

• AAA lid domain (AAA_lid_9) (294-391)

• ATPase family associated with various cellular activities (AAA) (AAA) (156-269)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (650-724)

• AAA domain (Cdc48 subfamily) (AAA_2) (479-642)

3D structure

• AlphaFold DB: C0M7F6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpE	Streptococcus mutans UA159	84.771	98.933	0.839
clpE	Streptococcus pneumoniae Rx1	82.228	100	0.827
clpE	Streptococcus pneumoniae D39	82.228	100	0.827
clpE	Streptococcus pneumoniae R6	82.228	100	0.827
clpE	Streptococcus pneumoniae TIGR4	82.095	100	0.825
clpC	Lactococcus lactis subsp. cremoris KW2	75.233	100	0.753
clpC	Bacillus subtilis subsp. subtilis str. 168	51.145	87.333	0.447
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	46.573	85.6	0.399
clpC	Streptococcus pneumoniae Rx1	48.052	82.133	0.395
clpC	Streptococcus pneumoniae D39	48.052	82.133	0.395
clpC	Streptococcus pneumoniae TIGR4	47.89	82.133	0.393
clpC	Streptococcus mutans UA159	47.504	82.8	0.393
clpC	Streptococcus thermophilus LMD-9	46.349	84	0.389
clpC	Streptococcus thermophilus LMG 18311	46.032	84	0.387