Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   SZO_RS02450 Genome accession   NC_012470
Coordinates   503313..504062 (+) Length   249 a.a.
NCBI ID   WP_012516119.1    Uniprot ID   B4U4E3
Organism   Streptococcus equi subsp. zooepidemicus     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 498313..509062
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SZO_RS10715 - 498597..498908 (+) 312 WP_269449450.1 recombinase family protein -
  SZO_RS10720 - 498924..499202 (+) 279 WP_228274835.1 hypothetical protein -
  SZO_RS10725 - 499239..499424 (+) 186 WP_269449451.1 DUF4368 domain-containing protein -
  SZO_RS02430 (SZO_04290) - 499545..500513 (+) 969 WP_012677511.1 helix-hairpin-helix domain-containing protein -
  SZO_RS02435 (SZO_04300) rlmD 500510..501877 (+) 1368 WP_012516122.1 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD -
  SZO_RS02440 (SZO_04310) - 502198..502455 (+) 258 WP_012516121.1 Blp family class II bacteriocin -
  SZO_RS02445 (SZO_04320) - 502472..502675 (+) 204 WP_012516120.1 TmhB bacteriocin enhancer peptide -
  SZO_RS02450 (SZO_04330) comE/blpR 503313..504062 (+) 750 WP_012516119.1 LytR/AlgR family response regulator transcription factor Regulator
  SZO_RS10935 (SZO_04340) - 504062..505396 (+) 1335 WP_012677512.1 sensor histidine kinase -
  SZO_RS02460 (SZO_04351) - 505518..505649 (-) 132 WP_012677513.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  SZO_RS02465 (SZO_04350) - 505749..507107 (-) 1359 WP_012677514.1 bacteriocin secretion accessory protein -

Sequence

Protein


Download         Length: 249 a.a.        Molecular weight: 29208.64 Da        Isoelectric Point: 8.4569

>NTDB_id=33460 SZO_RS02450 WP_012516119.1 503313..504062(+) (comE/blpR) [Streptococcus equi subsp. zooepidemicus]
MRVVILEDDMIQQRYLEKLIKELEVKHQLLFQGLDCFGRSHQLLSAIKKNCGQQLFFLDIEIKNEDKKGLEVARQIRQIN
PDAMIVFVTTHSEFMPLAFQYQVSALDYIDKELPQTEFVQRVETALLYAVRQNSETIAESAFYFTSRYAQVQVPFNDILY
IETSSRAHRVNLYTKKERMQFTGTLTDILKQESRFLQCHRSFLINPRNVVRVDKIERVVYFRNGSSCLIARSKMNSVLTT
IENLHRGDN

Nucleotide


Download         Length: 750 bp        

>NTDB_id=33460 SZO_RS02450 WP_012516119.1 503313..504062(+) (comE/blpR) [Streptococcus equi subsp. zooepidemicus]
GTGAGAGTAGTTATTTTAGAAGATGATATGATTCAGCAGAGATATTTAGAAAAGCTCATTAAAGAGCTTGAGGTTAAGCA
CCAGCTATTATTTCAAGGACTTGACTGTTTTGGAAGGTCTCACCAGCTATTAAGTGCTATCAAGAAGAACTGTGGTCAGC
AGCTATTCTTTTTAGATATTGAGATAAAAAATGAGGACAAAAAAGGGCTTGAGGTTGCTAGGCAAATTCGTCAGATAAAT
CCAGATGCGATGATTGTTTTTGTAACGACTCACTCGGAATTTATGCCCTTGGCTTTTCAGTATCAGGTATCTGCTTTGGA
CTATATCGATAAAGAGCTGCCCCAAACTGAGTTTGTTCAACGGGTAGAGACTGCTTTATTATATGCTGTGCGGCAAAATA
GTGAAACGATAGCGGAAAGTGCTTTTTATTTTACATCTCGTTATGCTCAGGTACAGGTGCCTTTTAATGATATCCTGTAT
ATTGAGACATCGTCACGAGCGCATCGTGTCAATTTGTATACAAAAAAGGAGAGAATGCAATTTACAGGGACTTTGACGGA
TATTTTGAAGCAAGAGTCTCGTTTTTTGCAATGTCATCGTTCTTTTTTGATTAATCCTAGGAATGTCGTTAGGGTAGATA
AGATTGAGCGAGTGGTTTATTTTCGAAATGGCTCTAGCTGCTTAATTGCTCGTAGTAAAATGAACAGTGTTTTAACAACA
ATTGAGAACCTACATAGAGGAGATAATTAA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-237)

Response regulator receiver domain (Response_reg)

(3-122)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB B4U4E3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

52.209

100

0.522
  comE/comE1 Streptococcus equinus JB1

40.586

95.984

0.39
  comE/comE2 Streptococcus equinus JB1

36.29

99.598

0.361

Multiple sequence alignment