Detailed information NTG0033455

Bioinformatically predicted

Overview

• Name: covR
• Type: Regulator
• Locus tag: SZO_RS01750
• Genome accession: NC_012470
• Coordinates: 366434..367120 (+)
• Length: 228 a.a.
• NCBI ID: WP_012516253.1
• Uniprot ID: U5Y8A0
• Organism: Streptococcus equi subsp. zooepidemicus
• Function: repress comR expression (predicted from homology) Competence regulation

Genomic Context

Location: 361434..372120

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SZO_RS01730 (SZO_03030)	rsmG	363097..363810 (-)	714	WP_012677409.1	16S rRNA (guanine(527)-N(7))-methyltransferase RsmG	-
SZO_RS01735 (SZO_03040)	-	363946..364503 (+)	558	WP_012677410.1	LemA family protein	-
SZO_RS01740 (SZO_03050)	htpX	364535..365428 (+)	894	WP_012516255.1	zinc metalloprotease HtpX	-
SZO_RS01745 (SZO_03060)	-	365716..366249 (+)	534	WP_012677411.1	YceD family protein	-
SZO_RS01750 (SZO_03070)	covR	366434..367120 (+)	687	WP_012516253.1	two-component system response regulator CovR	Regulator
SZO_RS01755 (SZO_03080)	-	367124..368614 (+)	1491	WP_012516252.1	HAMP domain-containing sensor histidine kinase	-
SZO_RS01760 (SZO_03090)	nrdR	368805..369299 (+)	495	WP_012516251.1	transcriptional regulator NrdR	-
SZO_RS01765 (SZO_03100)	-	369283..370446 (+)	1164	WP_173302778.1	helicase loader	-
SZO_RS01770 (SZO_03110)	dnaI	370447..371355 (+)	909	WP_012677413.1	primosomal protein DnaI	-

Sequence

Protein

• Length: 228 a.a.
• Molecular weight: 26580.56 Da
• Isoelectric Point: 4.6541

>NTDB_id=33455 SZO_RS01750 WP_012516253.1 366434..367120(+) (covR) [Streptococcus equi subsp. zooepidemicus]
MTKKILIIEDEKNLARFVSLELQHEGYEVTVEVNGREGLETALEKDFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKTPSQGVYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide

• Length: 687 bp

>NTDB_id=33455 SZO_RS01750 WP_012516253.1 366434..367120(+) (covR) [Streptococcus equi subsp. zooepidemicus]
ATGACAAAGAAAATTTTAATTATCGAAGATGAAAAGAATCTTGCAAGATTTGTTTCGCTTGAGCTACAACATGAGGGTTA
CGAGGTGACCGTCGAGGTTAATGGTCGTGAGGGCTTGGAGACAGCCCTAGAGAAGGACTTTGACTTAATCCTTCTTGATT
TGATGCTTCCTGAGATGGACGGATTTGAAGTGACACGTCGCTTGCAAACAGAAAAAACGACTTACATCATGATGATGACT
GCGCGTGACTCTATTATGGACGTTGTAGCCGGCTTGGATCGTGGTGCTGATGATTATATCGTGAAGCCATTTGCCATTGA
GGAATTGCTGGCGCGTATTCGTGCTATCTTCCGTCGTCAGGACATTGAGTCAGAGAAAAAGACTCCTAGTCAAGGCGTTT
ACCGCGACTTAGTCTTAAACCCTCAAAACCGCTCTGTCAATCGCGGTGATGACGAGATTTCACTGACTAAGCGTGAATAT
GACCTGCTTAATATTTTGATGACAAACATGAATCGTGTCATGACTCGTGAGGAGCTCTTGTCTAACGTTTGGAAATATGA
CGAGGCTGTTGAAACTAACGTTGTTGATGTTTATATTCGTTACCTTCGTGGGAAGATCGATATCCCTGGGAAAGAGTCTT
ACATTCAAACTGTTCGTGGAATGGGTTATGTGATTCGCGAGAAATAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (151-224)

• Response regulator receiver domain (Response_reg) (5-114)

3D structure

• AlphaFold DB: U5Y8A0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
covR	Streptococcus salivarius strain HSISS4	82.533	100	0.829
covR	Lactococcus lactis subsp. lactis strain DGCC12653	67.401	99.561	0.671
vicR	Streptococcus mutans UA159	43.29	100	0.439
micA	Streptococcus pneumoniae Cp1015	42.174	100	0.425