Detailed information NTG0033410

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: SPT_RS09655
• Genome accession: NC_012469
• Coordinates: 1825785..1826822 (-)
• Length: 345 a.a.
• NCBI ID: WP_000727277.1
• Uniprot ID: A0A0B7LHQ0
• Organism: Streptococcus pneumoniae Taiwan19F-14
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1820785..1831822

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPT_RS09635 (SPT_1942)	-	1821524..1822855 (-)	1332	WP_000390039.1	hemolysin family protein	-
SPT_RS09640 (SPT_1943)	endA	1823146..1823970 (-)	825	WP_001036785.1	DNA-entry nuclease EndA	Machinery gene
SPT_RS09645 (SPT_1944)	-	1824009..1824197 (-)	189	WP_001036519.1	DNA-directed RNA polymerase subunit beta	-
SPT_RS09650 (SPT_1945)	murA	1824190..1825473 (-)	1284	WP_000358028.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
SPT_RS12295	-	1825497..1825727 (-)	231	WP_000250392.1	DUF1146 family protein	-
SPT_RS09655 (SPT_1947)	sepM	1825785..1826822 (-)	1038	WP_000727277.1	SepM family pheromone-processing serine protease	Regulator
SPT_RS09660 (SPT_1948)	coaD	1826806..1827294 (-)	489	WP_001280731.1	pantetheine-phosphate adenylyltransferase	-
SPT_RS09665 (SPT_1949)	rsmD	1827284..1827823 (-)	540	WP_000706963.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
SPT_RS09670 (SPT_1950)	asnA	1827888..1828880 (-)	993	WP_000747993.1	aspartate--ammonia ligase	-
SPT_RS09675 (SPT_1952)	-	1828991..1829674 (-)	684	WP_001016917.1	Bax inhibitor-1/YccA family protein	-
SPT_RS09680 (SPT_1953)	-	1829730..1830470 (-)	741	WP_000152692.1	RNA methyltransferase	-
SPT_RS09685 (SPT_1954)	-	1830504..1830782 (+)	279	WP_001174613.1	acylphosphatase	-
SPT_RS09690 (SPT_1955)	yidC	1830860..1831786 (+)	927	WP_000835955.1	membrane protein insertase YidC	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37537.57 Da
• Isoelectric Point: 5.0724

>NTDB_id=33410 SPT_RS09655 WP_000727277.1 1825785..1826822(-) (sepM) [Streptococcus pneumoniae Taiwan19F-14]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=33410 SPT_RS09655 WP_000727277.1 1825785..1826822(-) (sepM) [Streptococcus pneumoniae Taiwan19F-14]
ATGAAAAAAAAGATTAGATGGCCCTTATACGTCATTGCGGCCTTGATTGTGACTTTCTTGGCATTTGTAGTGCCCTTGCC
TTATTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCCACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACAGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGATTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAGATTATCACCTTGGAAAATGGCAAAAATGGAATTGGAATCGGCTTGATTGACCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGTCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGCATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCCATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A0B7LHQ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.649	99.13	0.591