Detailed information NTG0033178

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: SPJ_RS09725
• Genome accession: NC_012466
• Coordinates: 1836185..1837222 (-)
• Length: 345 a.a.
• NCBI ID: WP_000727268.1
• Uniprot ID: A0A0U0L8C3
• Organism: Streptococcus pneumoniae JJA
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1831185..1842222

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPJ_RS09700 (SPJ_1956)	-	1831986..1833317 (-)	1332	WP_000390048.1	hemolysin family protein	-
SPJ_RS09705 (SPJ_1957)	endA	1833546..1834370 (-)	825	WP_001036779.1	DNA-entry nuclease EndA	Machinery gene
SPJ_RS09710 (SPJ_1958)	-	1834409..1834597 (-)	189	WP_001036519.1	DNA-directed RNA polymerase subunit beta	-
SPJ_RS09715 (SPJ_1959)	murA	1834590..1835873 (-)	1284	WP_000358028.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
SPJ_RS09720 (SPJ_1960)	-	1835897..1836127 (-)	231	WP_000250393.1	DUF1146 family protein	-
SPJ_RS09725 (SPJ_1961)	sepM	1836185..1837222 (-)	1038	WP_000727268.1	SepM family pheromone-processing serine protease	Regulator
SPJ_RS09730 (SPJ_1962)	coaD	1837206..1837694 (-)	489	WP_001280740.1	pantetheine-phosphate adenylyltransferase	-
SPJ_RS09735 (SPJ_1963)	rsmD	1837684..1838223 (-)	540	WP_000706963.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
SPJ_RS09740 (SPJ_1964)	asnA	1838288..1839280 (-)	993	WP_000747993.1	aspartate--ammonia ligase	-
SPJ_RS09750 (SPJ_1965)	-	1839392..1840075 (-)	684	WP_001016913.1	Bax inhibitor-1/YccA family protein	-
SPJ_RS09755 (SPJ_1966)	-	1840131..1840870 (-)	740	Protein_1848	RNA methyltransferase	-
SPJ_RS09760 (SPJ_1967)	-	1840904..1841182 (+)	279	WP_001174613.1	acylphosphatase	-
SPJ_RS09765 (SPJ_1968)	yidC	1841260..1842186 (+)	927	WP_000835941.1	membrane protein insertase YidC	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37551.60 Da
• Isoelectric Point: 5.0724

>NTDB_id=33178 SPJ_RS09725 WP_000727268.1 1836185..1837222(-) (sepM) [Streptococcus pneumoniae JJA]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKINDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=33178 SPJ_RS09725 WP_000727268.1 1836185..1837222(-) (sepM) [Streptococcus pneumoniae JJA]
ATGAAAAAAAAGATTAGATGGCCCTTATACGTCATTGCGGCCTTGATTGTGACTTTCTTGGCATTTGTAGTGCCCTTGCC
TTATTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAATAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCCACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACAGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGATTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAGATTATCACCTTGGAAAATGGCAAAAATGGAATTGGAATCGGCTTGATTGACCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGTCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGTATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

• PDZ domain (PDZ_2) (130-193)

3D structure

• AlphaFold DB: A0A0U0L8C3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.357	99.13	0.588