Detailed information NTG0331307

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: EJN89_RS11655
• Genome accession: NZ_CP034441
• Coordinates: 2244647..2245690 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain PMB 81-4
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2239647..2250690

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EJN89_RS11615	-	2240074..2240183 (+)	110	Protein_2176	hypothetical protein	-
EJN89_RS11620	-	2240212..2240625 (+)	414	WP_001837236.1	hypothetical protein	-
EJN89_RS11630	-	2241056..2242042 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
EJN89_RS11640	map	2242573..2243331 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
EJN89_RS11645	-	2243548..2243934 (+)	387	WP_001110179.1	hypothetical protein	-
EJN89_RS11650	liaF	2243949..2244650 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
EJN89_RS11655	vraS	2244647..2245690 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
EJN89_RS11660	vraR	2245680..2246309 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
EJN89_RS11665	-	2246421..2247632 (-)	1212	WP_000037091.1	YihY/virulence factor BrkB family protein	-
EJN89_RS11670	-	2247910..2248185 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
EJN89_RS11675	-	2248192..2248656 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
EJN89_RS11680	-	2248803..2249003 (+)	201	WP_000180460.1	DUF1128 family protein	-
EJN89_RS11685	-	2249006..2250262 (+)	1257	WP_001793428.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=331307 EJN89_RS11655 WP_001017131.1 2244647..2245690(+) (vraS) [Staphylococcus aureus strain PMB 81-4]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=331307 EJN89_RS11655 WP_001017131.1 2244647..2245690(+) (vraS) [Staphylococcus aureus strain PMB 81-4]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1