Detailed information NTG0330320

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: FP482_RS09965
• Genome accession: NZ_CP042153
• Coordinates: 2010953..2011996 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: Q99SZ7
• Organism: Staphylococcus aureus strain B4-59C
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2005953..2016996

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FP482_RS09935 (FP482_09930)	-	2006374..2007630 (-)	1257	WP_001795108.1	aminopeptidase	-
FP482_RS09940 (FP482_09935)	-	2007633..2007833 (-)	201	WP_000180460.1	DUF1128 family protein	-
FP482_RS09945 (FP482_09940)	-	2007980..2008444 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
FP482_RS09950 (FP482_09945)	-	2008451..2008726 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
FP482_RS09955 (FP482_09950)	-	2009004..2010221 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
FP482_RS09960 (FP482_09955)	vraR	2010334..2010963 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
FP482_RS09965 (FP482_09960)	vraS	2010953..2011996 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
FP482_RS09970 (FP482_09965)	liaF	2011993..2012694 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
FP482_RS09975 (FP482_09970)	-	2012709..2013095 (-)	387	WP_001110179.1	hypothetical protein	-
FP482_RS09980 (FP482_09975)	map	2013312..2014070 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
FP482_RS09985 (FP482_09980)	-	2014601..2015587 (+)	987	WP_000999717.1	aromatic acid exporter family protein	-
FP482_RS09990 (FP482_09985)	-	2016018..2016431 (-)	414	WP_001557448.1	hypothetical protein	-
FP482_RS09995 (FP482_09990)	-	2016460..2016570 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=330320 FP482_RS09965 WP_001017131.1 2010953..2011996(-) (vraS) [Staphylococcus aureus strain B4-59C]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=330320 FP482_RS09965 WP_001017131.1 2010953..2011996(-) (vraS) [Staphylococcus aureus strain B4-59C]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterProScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: Q99SZ7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1