Detailed information NTG0330239

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: FP484_RS12810
• Genome accession: NZ_CP042107
• Coordinates: 2540365..2541408 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: Q99SZ7
• Organism: Staphylococcus aureus strain B8-13D
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2535365..2546408

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FP484_RS12780 (FP484_12780)	-	2535786..2537042 (-)	1257	WP_001795108.1	aminopeptidase	-
FP484_RS12785 (FP484_12785)	-	2537045..2537245 (-)	201	WP_000180460.1	DUF1128 family protein	-
FP484_RS12790 (FP484_12790)	-	2537392..2537856 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
FP484_RS12795 (FP484_12795)	-	2537863..2538138 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
FP484_RS12800 (FP484_12800)	-	2538416..2539633 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
FP484_RS12805 (FP484_12805)	vraR	2539746..2540375 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
FP484_RS12810 (FP484_12810)	vraS	2540365..2541408 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
FP484_RS12815 (FP484_12815)	liaF	2541405..2542106 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
FP484_RS12820 (FP484_12820)	-	2542121..2542507 (-)	387	WP_001110179.1	hypothetical protein	-
FP484_RS12825 (FP484_12825)	map	2542724..2543482 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
FP484_RS12830 (FP484_12830)	-	2544013..2544999 (+)	987	WP_000999717.1	aromatic acid exporter family protein	-
FP484_RS12835 (FP484_12835)	-	2545430..2545843 (-)	414	WP_001557448.1	hypothetical protein	-
FP484_RS12840 (FP484_12840)	-	2545872..2545982 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=330239 FP484_RS12810 WP_001017131.1 2540365..2541408(-) (vraS) [Staphylococcus aureus strain B8-13D]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=330239 FP484_RS12810 WP_001017131.1 2540365..2541408(-) (vraS) [Staphylococcus aureus strain B8-13D]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterProScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: Q99SZ7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1