Detailed information NTG0330057

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: FP478_RS11020
• Genome accession: NZ_CP042043
• Coordinates: 2206153..2207196 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: Q99SZ7
• Organism: Staphylococcus aureus strain B2-15A
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2201153..2212196

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FP478_RS10990 (FP478_10990)	-	2201574..2202830 (-)	1257	WP_001795108.1	aminopeptidase	-
FP478_RS10995 (FP478_10995)	-	2202833..2203033 (-)	201	WP_000180460.1	DUF1128 family protein	-
FP478_RS11000 (FP478_11000)	-	2203180..2203644 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
FP478_RS11005 (FP478_11005)	-	2203651..2203926 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
FP478_RS11010 (FP478_11010)	-	2204204..2205421 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
FP478_RS11015 (FP478_11015)	vraR	2205534..2206163 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
FP478_RS11020 (FP478_11020)	vraS	2206153..2207196 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
FP478_RS11025 (FP478_11025)	liaF	2207193..2207894 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
FP478_RS11030 (FP478_11030)	-	2207909..2208295 (-)	387	WP_001110179.1	hypothetical protein	-
FP478_RS11035 (FP478_11035)	map	2208512..2209270 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
FP478_RS11040 (FP478_11040)	-	2209801..2210787 (+)	987	WP_000999717.1	FUSC family protein	-
FP478_RS11045 (FP478_11045)	-	2211218..2211631 (-)	414	WP_001557448.1	hypothetical protein	-
FP478_RS11050 (FP478_11050)	-	2211660..2211770 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=330057 FP478_RS11020 WP_001017131.1 2206153..2207196(-) (vraS) [Staphylococcus aureus strain B2-15A]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=330057 FP478_RS11020 WP_001017131.1 2206153..2207196(-) (vraS) [Staphylococcus aureus strain B2-15A]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterProScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: Q99SZ7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1