Detailed information NTG0032946

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: SUB_RS08660
• Genome accession: NC_012004
• Coordinates: 1727213..1729654 (-)
• Length: 813 a.a.
• NCBI ID: WP_015912034.1
• Uniprot ID: B9DW30
• Organism: Streptococcus uberis 0140J
• Function: degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 1722213..1734654

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SUB_RS09760	-	1723787..1724947 (-)	1161	WP_231837430.1	YSIRK-type signal peptide-containing protein	-
SUB_RS08650 (SUB1741)	groL	1725110..1726738 (-)	1629	WP_015912032.1	chaperonin GroEL	-
SUB_RS08655 (SUB1742)	groES	1726784..1727071 (-)	288	WP_015912033.1	co-chaperone GroES	-
SUB_RS08660 (SUB1743)	clpC	1727213..1729654 (-)	2442	WP_015912034.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
SUB_RS08665 (SUB1744)	-	1729654..1730115 (-)	462	WP_015912035.1	CtsR family transcriptional regulator	-
SUB_RS08670 (SUB1745)	-	1730329..1730532 (-)	204	WP_015912036.1	cold-shock protein	-
SUB_RS08675 (SUB1746)	-	1730763..1731089 (+)	327	WP_231837432.1	hypothetical protein	-
SUB_RS08680 (SUB1747)	-	1731091..1733160 (+)	2070	WP_015912038.1	cation:proton antiporter	-
SUB_RS08685 (SUB1748)	-	1733286..1734248 (+)	963	WP_015912039.1	VOC family protein	-

Sequence

Protein

• Length: 813 a.a.
• Molecular weight: 90408.96 Da
• Isoelectric Point: 6.5280

>NTDB_id=32946 SUB_RS08660 WP_015912034.1 1727213..1729654(-) (clpC) [Streptococcus uberis 0140J]
MTDYSLKMQAIFKQAQYQAARFDSPYLETWHLLLAMVVVNNSLAGLVFNEFENKVALEEYEAAAILAIGKAPNDDIKEFE
YKGQSKTLSHILSFADAIRNVTHANEVGSEHVLFAILLNPDIMATRLLELAGFKIKDDGKGDLKLADLRKAIEIQAAYSK
ETIKAIYELRKPKKAKTGGTFSDMMKPAGTAGELSDYTRDLTEMASQGLLEPVIGREKEITRMVQVLSRKTKNNPVLVGE
AGVGKTALAYGLAQRIVTGEIPYELRDMRVLELDMMSVVAGTRFRGDFEERMNQIIDDIESDGHIILFVDELHTIMGSGS
GIDSTLDAANILKPALSRGTLHMVGATTQEEYQKHIEKDAALSRRFSKVLIEEPSIEDAYKILSGLKKSYESYHNVTISD
QAIKTAVKVAHRYLTSKHLPDSAIDLLDEASATVQSFVKKEAPAFITPIDQAIIKGDFKTVSQLLKASKAKPQKPTPVTE
EDIMSTLSKLSGIPLEKISKADSQKYLNLEKELHKRVIGQEDAVSAISRAIRRNQSGIRTGKRPIGSFMFLGPTGVGKTE
LAKALAELLFDDESALIRFDMSEYMEKFAASRLNGAPPGYVGYDEGGELTEKVRNKPYSVLLFDEVEKAHPDIFNVLLQV
LDDGQLTDSRGRKVDFSNTIIIMTSNLGATALRDDKTVGFGAKDINHDHSAMEKRILEELKKTYRPEFINRIDEKVVFHS
LSQEDMRQVVAIMVQPLIKNLEEKGITLKIQPSALKYLSEVGYDVEMGARPLRRTIQTEIEDKLSEFILSGQLKTGKTLK
IGMSQGKLKFDMV

Nucleotide

• Length: 2442 bp

>NTDB_id=32946 SUB_RS08660 WP_015912034.1 1727213..1729654(-) (clpC) [Streptococcus uberis 0140J]
ATGACAGATTATTCACTCAAAATGCAAGCTATTTTTAAACAAGCACAATACCAAGCGGCGCGTTTTGATAGCCCCTATTT
AGAAACTTGGCACCTCTTATTGGCAATGGTTGTTGTTAATAATTCACTAGCTGGCCTTGTTTTTAATGAATTTGAAAATA
AGGTTGCCTTGGAAGAATATGAAGCGGCAGCTATCTTAGCCATTGGCAAAGCTCCAAATGATGATATTAAGGAGTTTGAA
TATAAAGGTCAGTCAAAAACACTTTCTCATATTTTGTCCTTTGCTGATGCTATTCGAAATGTTACACATGCCAATGAAGT
AGGATCAGAGCATGTTCTTTTTGCTATCTTATTAAATCCTGATATTATGGCAACTCGTTTGCTAGAATTAGCTGGATTTA
AAATCAAAGATGATGGCAAAGGCGATTTGAAATTGGCTGATTTAAGAAAAGCCATTGAAATTCAAGCTGCTTATAGTAAA
GAAACCATTAAAGCTATCTACGAACTCAGAAAACCCAAAAAAGCCAAAACAGGCGGTACTTTCTCAGATATGATGAAACC
AGCTGGCACTGCGGGAGAATTATCAGATTATACGAGAGATTTGACAGAAATGGCAAGTCAAGGCTTACTTGAGCCTGTTA
TTGGCAGAGAAAAAGAAATCACTCGAATGGTTCAAGTCTTAAGTCGTAAAACGAAAAATAATCCAGTTTTAGTCGGTGAG
GCTGGTGTTGGTAAGACAGCATTGGCCTATGGCTTAGCCCAACGGATTGTGACTGGTGAGATTCCATACGAACTTCGTGA
TATGCGTGTCTTAGAATTAGACATGATGAGTGTGGTGGCAGGTACGCGTTTTCGTGGTGATTTTGAAGAACGCATGAATC
AAATTATTGATGATATTGAAAGTGACGGTCATATCATTCTCTTTGTCGATGAATTACACACTATTATGGGATCTGGCAGT
GGTATTGATAGCACTTTAGATGCTGCAAATATCCTCAAACCAGCTCTCTCAAGAGGAACCCTACATATGGTTGGGGCAAC
TACTCAAGAAGAGTATCAAAAACATATTGAAAAAGATGCCGCTTTATCTCGTCGTTTCTCAAAAGTTTTGATTGAAGAAC
CAAGTATAGAGGATGCCTACAAGATACTATCAGGGTTGAAAAAATCTTACGAAAGCTATCATAATGTCACCATCTCAGAT
CAAGCCATCAAAACAGCAGTCAAAGTTGCTCATCGCTATTTGACGAGCAAGCACTTACCTGATTCTGCGATTGATTTATT
AGATGAAGCTAGCGCAACGGTTCAAAGTTTCGTCAAAAAAGAGGCGCCAGCCTTCATCACACCAATTGACCAAGCCATCA
TAAAAGGTGATTTTAAAACAGTTAGCCAACTTTTGAAAGCTTCCAAGGCTAAGCCCCAGAAACCAACGCCTGTTACTGAA
GAAGATATCATGTCTACATTAAGTAAATTGTCAGGAATTCCACTGGAAAAAATTAGCAAGGCAGATAGTCAGAAATACCT
TAACCTGGAAAAAGAATTACATAAGCGTGTTATCGGTCAAGAGGATGCAGTCTCAGCAATTTCAAGAGCTATCAGACGCA
ATCAGTCTGGTATTCGAACAGGTAAACGTCCAATTGGCTCCTTTATGTTCCTTGGACCGACAGGTGTTGGGAAAACAGAA
TTAGCAAAAGCTTTAGCAGAACTCTTATTCGATGATGAATCAGCTCTCATTCGTTTTGATATGTCAGAATACATGGAAAA
ATTCGCTGCTAGCCGTTTAAATGGAGCACCTCCAGGATATGTTGGCTATGACGAGGGCGGTGAGTTGACCGAAAAAGTAC
GTAACAAACCCTATTCTGTTCTTCTCTTCGATGAAGTTGAAAAAGCCCATCCAGATATCTTTAACGTTTTGTTACAAGTC
TTGGATGATGGACAATTAACTGATTCTCGTGGGCGAAAAGTCGATTTTTCAAATACAATCATTATCATGACAAGTAATTT
AGGTGCTACAGCGCTTCGAGATGATAAAACGGTTGGATTTGGTGCTAAAGATATCAACCATGATCATTCGGCCATGGAAA
AACGCATCTTAGAAGAATTGAAAAAAACCTACCGACCAGAATTTATCAACCGAATTGATGAAAAAGTTGTCTTCCATAGC
TTAAGTCAAGAAGACATGCGACAAGTTGTCGCGATTATGGTTCAACCCTTGATTAAGAACTTGGAAGAAAAAGGGATTAC
CCTCAAAATACAACCATCTGCATTAAAATATTTGTCTGAAGTCGGTTATGATGTTGAGATGGGGGCAAGACCACTAAGAC
GAACCATCCAAACAGAAATCGAAGACAAGTTGTCAGAATTCATTTTATCTGGTCAACTTAAAACTGGTAAGACTTTAAAA
ATTGGTATGAGCCAAGGTAAATTAAAATTTGATATGGTCTAA

Domains

Predicted by InterproScan.

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (721-801)

• AAA domain (Cdc48 subfamily) (AAA_2) (543-714)

• AAA lid domain (AAA_lid_9) (375-451)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (104-136)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (19-51)

• ATPase family associated with various cellular activities (AAA) (AAA) (236-368)

3D structure

• AlphaFold DB: B9DW30

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Streptococcus mutans UA159	74.939	100	0.75
clpC	Streptococcus thermophilus LMG 18311	71.673	100	0.722
clpC	Streptococcus thermophilus LMD-9	71.551	100	0.721
clpC	Streptococcus pneumoniae TIGR4	65.148	99.877	0.651
clpC	Streptococcus pneumoniae Rx1	65.025	99.877	0.649
clpC	Streptococcus pneumoniae D39	65.025	99.877	0.649
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	49.94	100	0.512
clpC	Bacillus subtilis subsp. subtilis str. 168	43.943	100	0.455