Detailed information NTG0329155

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: EH163_RS08345
• Genome accession: NZ_CP034115
• Coordinates: 1650964..1652010 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain CDC121
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1645964..1657010

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EH163_RS08320	-	1647105..1647641 (+)	537	WP_001830372.1	hypothetical protein	-
EH163_RS08325	-	1647792..1648778 (-)	987	WP_001830388.1	aromatic acid exporter family protein	-
EH163_RS08330	map	1648952..1649707 (+)	756	WP_001830397.1	type I methionyl aminopeptidase	-
EH163_RS08335	-	1649865..1650251 (+)	387	WP_001830382.1	hypothetical protein	-
EH163_RS08340	liaF	1650266..1650967 (+)	702	WP_001830436.1	cell wall-active antibiotics response protein LiaF	-
EH163_RS08345	vraS	1650964..1652010 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
EH163_RS08350	vraR	1652000..1652629 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
EH163_RS08355	-	1652686..1653864 (-)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
EH163_RS08360	-	1654271..1654555 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
EH163_RS08365	-	1654563..1655027 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
EH163_RS08370	-	1655168..1655383 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
EH163_RS08375	-	1655385..1656626 (+)	1242	WP_001832467.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=329155 EH163_RS08345 WP_001830374.1 1650964..1652010(+) (vraS) [Staphylococcus epidermidis strain CDC121]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=329155 EH163_RS08345 WP_001830374.1 1650964..1652010(+) (vraS) [Staphylococcus epidermidis strain CDC121]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92