Detailed information NTG0329119

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: EH162_RS08020
• Genome accession: NZ_CP034111
• Coordinates: 1593752..1594798 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain CDC120
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1588752..1599798

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EH162_RS07995	-	1589893..1590429 (+)	537	WP_001830372.1	hypothetical protein	-
EH162_RS08000	-	1590580..1591566 (-)	987	WP_001830388.1	aromatic acid exporter family protein	-
EH162_RS08005	map	1591740..1592495 (+)	756	WP_001830397.1	type I methionyl aminopeptidase	-
EH162_RS08010	-	1592653..1593039 (+)	387	WP_001830382.1	hypothetical protein	-
EH162_RS08015	liaF	1593054..1593755 (+)	702	WP_001830436.1	cell wall-active antibiotics response protein LiaF	-
EH162_RS08020	vraS	1593752..1594798 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
EH162_RS08025	vraR	1594788..1595417 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
EH162_RS08030	-	1595474..1596652 (-)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
EH162_RS08035	-	1597059..1597343 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
EH162_RS08040	-	1597351..1597815 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
EH162_RS08045	-	1597956..1598171 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
EH162_RS08050	-	1598173..1599414 (+)	1242	WP_001832467.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=329119 EH162_RS08020 WP_001830374.1 1593752..1594798(+) (vraS) [Staphylococcus epidermidis strain CDC120]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=329119 EH162_RS08020 WP_001830374.1 1593752..1594798(+) (vraS) [Staphylococcus epidermidis strain CDC120]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92