Detailed information NTG0329022

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: SaO267_RS10845
• Genome accession: NZ_CP034102
• Coordinates: 2053699..2054742 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain O267
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2048699..2059742

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SaO267_RS10815 (SaO267_01988)	-	2049120..2050376 (-)	1257	WP_001793428.1	aminopeptidase	-
SaO267_RS10820 (SaO267_01989)	-	2050379..2050579 (-)	201	WP_000180462.1	DUF1128 family protein	-
SaO267_RS10825 (SaO267_01990)	-	2050726..2051190 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
SaO267_RS10830 (SaO267_01991)	-	2051197..2051472 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
SaO267_RS10835 (SaO267_01992)	-	2051750..2052967 (+)	1218	WP_000037094.1	YihY/virulence factor BrkB family protein	-
SaO267_RS10840 (SaO267_01993)	vraR	2053080..2053709 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
SaO267_RS10845 (SaO267_01994)	vraS	2053699..2054742 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
SaO267_RS10850 (SaO267_01995)	liaF	2054739..2055440 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
SaO267_RS10855 (SaO267_01996)	-	2055455..2055841 (-)	387	WP_001110180.1	hypothetical protein	-
SaO267_RS10860 (SaO267_01997)	map	2056058..2056816 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
SaO267_RS10865 (SaO267_01998)	-	2057388..2058374 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
SaO267_RS10870 (SaO267_01999)	-	2058566..2058979 (-)	414	WP_014532664.1	hypothetical protein	-
SaO267_RS10875	-	2059008..2059120 (-)	113	Protein_2035	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=329022 SaO267_RS10845 WP_001017131.1 2053699..2054742(-) (vraS) [Staphylococcus aureus strain O267]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=329022 SaO267_RS10845 WP_001017131.1 2053699..2054742(-) (vraS) [Staphylococcus aureus strain O267]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATTTTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1