Detailed information NTG0327607

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: EFD77_RS10140
• Genome accession: NZ_CP033982
• Coordinates: 2027796..2028839 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain P2D8C1
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2022796..2033839

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EFD77_RS10110 (EFD77_10555)	-	2023217..2024473 (-)	1257	WP_001795108.1	aminopeptidase	-
EFD77_RS10115 (EFD77_10560)	-	2024476..2024676 (-)	201	WP_000180460.1	DUF1128 family protein	-
EFD77_RS10120 (EFD77_10565)	-	2024823..2025287 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
EFD77_RS10125 (EFD77_10570)	-	2025294..2025569 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
EFD77_RS10130 (EFD77_10575)	-	2025847..2027064 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
EFD77_RS10135 (EFD77_10580)	vraR	2027177..2027806 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
EFD77_RS10140 (EFD77_10585)	vraS	2027796..2028839 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
EFD77_RS10145 (EFD77_10590)	liaF	2028836..2029537 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
EFD77_RS10150 (EFD77_10595)	-	2029552..2029938 (-)	387	WP_001110179.1	hypothetical protein	-
EFD77_RS10155 (EFD77_10600)	map	2030155..2030913 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
EFD77_RS10160 (EFD77_10610)	-	2031444..2032430 (+)	987	WP_000999717.1	FUSC family protein	-
EFD77_RS10165 (EFD77_10620)	-	2032861..2033274 (-)	414	WP_001557448.1	hypothetical protein	-
EFD77_RS10170 (EFD77_10625)	-	2033303..2033413 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=327607 EFD77_RS10140 WP_001017131.1 2027796..2028839(-) (vraS) [Staphylococcus aureus strain P2D8C1]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=327607 EFD77_RS10140 WP_001017131.1 2027796..2028839(-) (vraS) [Staphylococcus aureus strain P2D8C1]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1