Detailed information
Bioinformatically predicted
Overview
| Name | ccrB | Type | Machinery gene |
| Locus tag | EFD77_RS00600 | Genome accession | NZ_CP033982 |
| Coordinates | 86530..88158 (-) | Length | 542 a.a. |
| NCBI ID | WP_156667967.1 | Uniprot ID | - |
| Organism | Staphylococcus aureus strain P2D8C1 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 81387..125034 | 86530..88158 | within | 0 |
| SCCmec | 68251..89529 | 86530..88158 | within | 0 |
Gene organization within MGE regions
Location: 68251..125034
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EFD77_RS00495 (EFD77_00520) | mecA | 68251..70260 (-) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| EFD77_RS00500 (EFD77_00525) | mecR1 | 70357..72114 (+) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| EFD77_RS00505 (EFD77_00530) | mecI | 72114..72485 (+) | 372 | WP_000369214.1 | mecA-type methicillin resistance repressor MecI | - |
| EFD77_RS00510 (EFD77_00535) | psm-mec | 72570..72638 (-) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| EFD77_RS00515 (EFD77_00540) | - | 72972..74102 (+) | 1131 | WP_010922808.1 | ROK family transcriptional regulator | - |
| EFD77_RS00520 (EFD77_00545) | cstB | 74216..75542 (-) | 1327 | Protein_60 | persulfide dioxygenase-sulfurtransferase CstB | - |
| EFD77_RS00525 (EFD77_00550) | - | 75574..76638 (-) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| EFD77_RS00530 (EFD77_00555) | cstR | 76774..77034 (+) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| EFD77_RS00535 (EFD77_00560) | - | 77034..77672 (+) | 639 | Protein_63 | sulfite exporter TauE/SafE family protein | - |
| EFD77_RS00545 (EFD77_00570) | - | 78017..78679 (-) | 663 | WP_001092058.1 | class I SAM-dependent methyltransferase | - |
| EFD77_RS14695 (EFD77_00580) | - | 79071..79130 (+) | 60 | WP_010959190.1 | erythromycin resistance leader peptide | - |
| EFD77_RS00555 (EFD77_00585) | erm(A) | 79213..79944 (+) | 732 | WP_001072201.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) | - |
| EFD77_RS00560 (EFD77_00590) | - | 80070..80852 (-) | 783 | WP_000067268.1 | aminoglycoside nucleotidyltransferase ANT(9)-Ia | - |
| EFD77_RS00565 (EFD77_00595) | - | 81003..81380 (-) | 378 | WP_000361059.1 | DUF6262 family protein | - |
| EFD77_RS00570 (EFD77_00600) | - | 81387..83279 (-) | 1893 | WP_001557544.1 | site-specific integrase | - |
| EFD77_RS00575 (EFD77_00605) | - | 83276..84361 (-) | 1086 | WP_000868132.1 | tyrosine-type recombinase/integrase | - |
| EFD77_RS00580 (EFD77_00610) | - | 84402..84719 (-) | 318 | WP_000659050.1 | JAB domain-containing protein | - |
| EFD77_RS00585 (EFD77_00615) | - | 84740..85246 (-) | 507 | WP_001092169.1 | DUF1643 domain-containing protein | - |
| EFD77_RS00590 (EFD77_00620) | - | 85264..85575 (-) | 312 | WP_000700853.1 | DUF960 family protein | - |
| EFD77_RS00595 (EFD77_00625) | - | 85662..86012 (-) | 351 | WP_000859155.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| EFD77_RS00600 (EFD77_00630) | ccrB | 86530..88158 (-) | 1629 | WP_156667967.1 | cassette chromosome recombinase CcrB | Machinery gene |
| EFD77_RS00605 (EFD77_00635) | ccrA | 88180..89529 (-) | 1350 | WP_000815646.1 | cassette chromosome recombinase CcrA | Machinery gene |
| EFD77_RS00610 (EFD77_00640) | cch1 | 89763..91556 (-) | 1794 | WP_000195105.1 | cassette chromosome replicative helicase | - |
| EFD77_RS00615 (EFD77_00645) | ssb | 91556..91852 (-) | 297 | WP_000273824.1 | cassette chromosome ssDNA-binding protein | - |
| EFD77_RS00620 (EFD77_00650) | - | 92045..93091 (-) | 1047 | WP_001060127.1 | hypothetical protein | - |
| EFD77_RS00625 (EFD77_00655) | - | 93342..94483 (-) | 1142 | Protein_80 | IS3-like element ISSau4 family transposase | - |
| EFD77_RS00630 (EFD77_00660) | - | 94994..95929 (-) | 936 | Protein_81 | YfcC family protein | - |
| EFD77_RS00635 (EFD77_00665) | - | 96642..97337 (-) | 696 | WP_000858967.1 | response regulator transcription factor | - |
| EFD77_RS00640 (EFD77_00670) | - | 97312..99981 (-) | 2670 | WP_000446429.1 | sensor histidine kinase | - |
| EFD77_RS00645 (EFD77_00675) | kdpF | 100148..100228 (+) | 81 | WP_000631574.1 | K(+)-transporting ATPase subunit F | - |
| EFD77_RS00650 (EFD77_00680) | kdpA | 100249..101925 (+) | 1677 | WP_000029430.1 | potassium-transporting ATPase subunit KdpA | - |
| EFD77_RS00655 (EFD77_00685) | - | 101944..103965 (+) | 2022 | WP_000852430.1 | K(+)-transporting ATPase subunit B | - |
| EFD77_RS00660 (EFD77_00690) | - | 103981..104538 (+) | 558 | WP_001193482.1 | K(+)-transporting ATPase subunit C | - |
| EFD77_RS00665 (EFD77_00695) | - | 105083..105952 (-) | 870 | WP_000626133.1 | hypothetical protein | - |
| EFD77_RS00670 (EFD77_00700) | - | 105962..106858 (-) | 897 | WP_000411461.1 | DUF927 domain-containing protein | - |
| EFD77_RS00675 (EFD77_00710) | - | 107977..108603 (-) | 627 | WP_001176969.1 | hypothetical protein | - |
| EFD77_RS00680 (EFD77_00715) | - | 108718..110226 (+) | 1509 | WP_001001347.1 | protein kinase domain-containing protein | - |
| EFD77_RS00685 (EFD77_00720) | - | 110476..110610 (-) | 135 | WP_001790628.1 | hypothetical protein | - |
| EFD77_RS00690 (EFD77_00725) | - | 110574..110666 (+) | 93 | WP_001790000.1 | hypothetical protein | - |
| EFD77_RS00695 (EFD77_00730) | - | 110813..112558 (+) | 1746 | WP_000700190.1 | DUF6119 family protein | - |
| EFD77_RS00700 (EFD77_00735) | - | 112656..113011 (-) | 356 | Protein_95 | tRNA-dihydrouridine synthase | - |
| EFD77_RS00705 (EFD77_00740) | - | 113316..113404 (-) | 89 | Protein_96 | hypothetical protein | - |
| EFD77_RS00710 (EFD77_00745) | - | 113502..114257 (-) | 756 | WP_000355845.1 | sulfite exporter TauE/SafE family protein | - |
| EFD77_RS00715 (EFD77_00750) | cstR | 114257..114517 (-) | 261 | WP_001105088.1 | persulfide-sensing transcriptional repressor CstR | - |
| EFD77_RS00720 (EFD77_00755) | cstA | 114654..115718 (+) | 1065 | WP_000816133.1 | persulfide response sulfurtransferase CstA | - |
| EFD77_RS00725 (EFD77_00760) | cstB | 115749..117083 (+) | 1335 | WP_000465472.1 | persulfide dioxygenase-sulfurtransferase CstB | - |
| EFD77_RS00730 (EFD77_00765) | sqr | 117102..118295 (+) | 1194 | WP_001033018.1 | type II sulfide:quinone oxidoreductase Sqr | - |
| EFD77_RS14670 | - | 118562..118776 (-) | 215 | Protein_102 | universal stress protein | - |
| EFD77_RS00740 (EFD77_00780) | - | 118962..119948 (-) | 987 | WP_000662022.1 | tRNA dihydrouridine synthase | - |
| EFD77_RS00745 (EFD77_00785) | - | 120257..120460 (+) | 204 | WP_000389759.1 | DUF6007 family protein | - |
| EFD77_RS00750 (EFD77_00790) | - | 120509..120805 (+) | 297 | WP_000201644.1 | TfoX/Sxy family protein | - |
| EFD77_RS00755 (EFD77_00795) | - | 121013..121615 (+) | 603 | WP_000908956.1 | hypothetical protein | - |
| EFD77_RS00760 (EFD77_00800) | - | 121882..125034 (+) | 3153 | WP_000080564.1 | DEAD/DEAH box helicase | - |
Sequence
Protein
Download Length: 542 a.a. Molecular weight: 62650.81 Da Isoelectric Point: 9.8600
>NTDB_id=327575 EFD77_RS00600 WP_156667967.1 86530..88158(-) (ccrB) [Staphylococcus aureus strain P2D8C1]
MQQLKTKRVGIYVRVSTEMQSTEGYSIDGQINQIKEYCDFHHFEVKDIYADRGISGKSMNRPELQRILKDAKEGYIDCVM
VYKTNRLARNTSDLLKIVEDLHKQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPNSKHELMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGKPFSISSITYILANPFYIGKIQFAK
YKDWSEKRRKGLNDKPVIAEGKHSPIINQDLWDKVQMRKKQVSQKPQVHGKGTNLLTGIIHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEDYVMKQILEIVKSDKVIQRVVTHVNQENQVDGAALHHDIAYKQQQYD
EVQIKLNNLIKSIEDNPDLTSVIRPSIQKYEKQLNDITNQINQLKNQQNEDKPLFDAKEISKLLQHIFHDIKHIEKSRLK
ALYLSVIDRIDIKKDGNHKKQFYVTLKLNNEIIKQLFNNKQLDEVHLSTSSLFLPQTLYLTI
MQQLKTKRVGIYVRVSTEMQSTEGYSIDGQINQIKEYCDFHHFEVKDIYADRGISGKSMNRPELQRILKDAKEGYIDCVM
VYKTNRLARNTSDLLKIVEDLHKQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPNSKHELMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGKPFSISSITYILANPFYIGKIQFAK
YKDWSEKRRKGLNDKPVIAEGKHSPIINQDLWDKVQMRKKQVSQKPQVHGKGTNLLTGIIHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEDYVMKQILEIVKSDKVIQRVVTHVNQENQVDGAALHHDIAYKQQQYD
EVQIKLNNLIKSIEDNPDLTSVIRPSIQKYEKQLNDITNQINQLKNQQNEDKPLFDAKEISKLLQHIFHDIKHIEKSRLK
ALYLSVIDRIDIKKDGNHKKQFYVTLKLNNEIIKQLFNNKQLDEVHLSTSSLFLPQTLYLTI
Nucleotide
Download Length: 1629 bp
>NTDB_id=327575 EFD77_RS00600 WP_156667967.1 86530..88158(-) (ccrB) [Staphylococcus aureus strain P2D8C1]
ATGCAACAACTTAAAACAAAACGTGTCGGTATCTATGTACGTGTATCAACAGAAATGCAAAGCACAGAAGGTTATAGTAT
CGACGGACAAATCAATCAAATCAAAGAATACTGTGACTTCCATCATTTTGAAGTTAAAGATATATACGCTGACCGTGGTA
TTTCAGGTAAATCTATGAATCGACCTGAGCTCCAACGTATATTGAAGGATGCGAAAGAAGGCTATATCGACTGTGTTATG
GTCTACAAAACAAACCGATTAGCTCGTAATACATCTGATCTTCTCAAAATTGTCGAAGATTTACACAAACAAAATGTCGA
ATTTTTCAGTTTATCAGAGCGTATGGAAGTCAATACTTCATCGGGTAAGCTCATGTTACAAATACTTGCGAGTTTCTCAG
AATTCGAACGTAATAACATTGTCGAGAATGTATTTATGGGTCAAACGAGACGTGCCCAAGAAGGCTATTATCAAGGCAAT
TTGCCGCTGGGCTATGACAAAATACCTAATAGTAAACATGAACTGATGATTAATCAACATGAAGCTAATATTGTGAAATA
TATATTCGAGTCCTATGCCAAAGGCCATGGCTATCGTAAAATAGCCAATGCATTAAATCACAAAGGCTATGTCACTAAAA
AGGGTAAACCTTTTAGTATTAGTTCTATCACATATATATTAGCTAACCCATTCTATATCGGCAAAATTCAATTTGCGAAA
TACAAAGATTGGAGTGAAAAACGTCGTAAAGGGCTTAATGATAAACCAGTGATAGCTGAAGGTAAGCATTCCCCCATTAT
TAATCAAGATTTATGGGATAAAGTACAAATGCGTAAAAAACAAGTCAGTCAAAAACCCCAAGTCCATGGCAAAGGAACGA
ATCTGCTTACAGGCATTATTCACTGTCCCCAATGTGGCGCACCTATGGCAGCAAGCAATACCACGAATACACTTAAAGAC
GGGACTAAGAAACGTATTCGTTACTATTCATGTAGTAATTTTCGGAACAAGGGTTCCAAAGTATGTTCGGCAAACAGTGT
AAGAGCTGATGTGATTGAAGATTATGTGATGAAGCAAATACTTGAAATAGTCAAAAGTGATAAAGTCATTCAACGCGTAG
TAACACACGTCAATCAAGAAAATCAAGTTGATGGCGCTGCACTTCATCACGATATTGCTTATAAGCAACAACAATATGAT
GAAGTACAAATCAAACTAAATAACTTGATTAAAAGCATCGAGGATAATCCGGACTTAACATCAGTAATCAGACCAAGTAT
TCAAAAATATGAAAAGCAACTCAATGACATTACGAATCAAATCAACCAACTCAAAAATCAACAAAATGAAGATAAGCCTT
TATTTGATGCCAAAGAAATCAGTAAACTATTACAACACATCTTTCATGATATTAAGCACATAGAAAAATCTCGACTCAAA
GCATTGTATCTATCAGTGATTGATCGCATTGATATTAAAAAAGATGGTAATCATAAAAAACAATTCTATGTCACACTCAA
ACTTAATAACGAAATCATAAAACAACTTTTCAATAATAAACAACTCGACGAAGTGCATCTCAGCACTTCGTCTTTGTTTT
TGCCCCAAACACTATATCTTACTATTTAG
ATGCAACAACTTAAAACAAAACGTGTCGGTATCTATGTACGTGTATCAACAGAAATGCAAAGCACAGAAGGTTATAGTAT
CGACGGACAAATCAATCAAATCAAAGAATACTGTGACTTCCATCATTTTGAAGTTAAAGATATATACGCTGACCGTGGTA
TTTCAGGTAAATCTATGAATCGACCTGAGCTCCAACGTATATTGAAGGATGCGAAAGAAGGCTATATCGACTGTGTTATG
GTCTACAAAACAAACCGATTAGCTCGTAATACATCTGATCTTCTCAAAATTGTCGAAGATTTACACAAACAAAATGTCGA
ATTTTTCAGTTTATCAGAGCGTATGGAAGTCAATACTTCATCGGGTAAGCTCATGTTACAAATACTTGCGAGTTTCTCAG
AATTCGAACGTAATAACATTGTCGAGAATGTATTTATGGGTCAAACGAGACGTGCCCAAGAAGGCTATTATCAAGGCAAT
TTGCCGCTGGGCTATGACAAAATACCTAATAGTAAACATGAACTGATGATTAATCAACATGAAGCTAATATTGTGAAATA
TATATTCGAGTCCTATGCCAAAGGCCATGGCTATCGTAAAATAGCCAATGCATTAAATCACAAAGGCTATGTCACTAAAA
AGGGTAAACCTTTTAGTATTAGTTCTATCACATATATATTAGCTAACCCATTCTATATCGGCAAAATTCAATTTGCGAAA
TACAAAGATTGGAGTGAAAAACGTCGTAAAGGGCTTAATGATAAACCAGTGATAGCTGAAGGTAAGCATTCCCCCATTAT
TAATCAAGATTTATGGGATAAAGTACAAATGCGTAAAAAACAAGTCAGTCAAAAACCCCAAGTCCATGGCAAAGGAACGA
ATCTGCTTACAGGCATTATTCACTGTCCCCAATGTGGCGCACCTATGGCAGCAAGCAATACCACGAATACACTTAAAGAC
GGGACTAAGAAACGTATTCGTTACTATTCATGTAGTAATTTTCGGAACAAGGGTTCCAAAGTATGTTCGGCAAACAGTGT
AAGAGCTGATGTGATTGAAGATTATGTGATGAAGCAAATACTTGAAATAGTCAAAAGTGATAAAGTCATTCAACGCGTAG
TAACACACGTCAATCAAGAAAATCAAGTTGATGGCGCTGCACTTCATCACGATATTGCTTATAAGCAACAACAATATGAT
GAAGTACAAATCAAACTAAATAACTTGATTAAAAGCATCGAGGATAATCCGGACTTAACATCAGTAATCAGACCAAGTAT
TCAAAAATATGAAAAGCAACTCAATGACATTACGAATCAAATCAACCAACTCAAAAATCAACAAAATGAAGATAAGCCTT
TATTTGATGCCAAAGAAATCAGTAAACTATTACAACACATCTTTCATGATATTAAGCACATAGAAAAATCTCGACTCAAA
GCATTGTATCTATCAGTGATTGATCGCATTGATATTAAAAAAGATGGTAATCATAAAAAACAATTCTATGTCACACTCAA
ACTTAATAACGAAATCATAAAACAACTTTTCAATAATAAACAACTCGACGAAGTGCATCTCAGCACTTCGTCTTTGTTTT
TGCCCCAAACACTATATCTTACTATTTAG
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrB | Staphylococcus aureus N315 |
99.815 |
100 |
0.998 |