Detailed information NTG0326925

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: EHF40_RS06915
• Genome accession: NZ_CP033907
• Coordinates: 1314529..1315566 (-)
• Length: 345 a.a.
• NCBI ID: WP_002983824.1
• Uniprot ID: A0A4U9C0Q7
• Organism: Streptococcus pyogenes strain Duke-Large
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1309529..1320566

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EHF40_RS06895 (EHF40_06895)	-	1310278..1310905 (+)	628	Protein_1280	A24 family peptidase	-
EHF40_RS06900 (EHF40_06900)	rlmN	1310987..1312066 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
EHF40_RS06905 (EHF40_06905)	-	1312070..1312690 (-)	621	WP_002992791.1	YutD family protein	-
EHF40_RS06910 (EHF40_06910)	-	1313138..1314115 (-)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
EHF40_RS06915 (EHF40_06915)	sepM	1314529..1315566 (-)	1038	WP_002983824.1	SepM family pheromone-processing serine protease	Regulator
EHF40_RS06920 (EHF40_06920)	coaD	1315553..1316044 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
EHF40_RS06925 (EHF40_06925)	rsmD	1316034..1316573 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
EHF40_RS06930 (EHF40_06930)	asnA	1316696..1317688 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
EHF40_RS06935 (EHF40_06935)	arcC	1318001..1318951 (-)	951	WP_011528820.1	carbamate kinase	-
EHF40_RS06940 (EHF40_06940)	-	1318971..1320302 (-)	1332	WP_011054719.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37555.27 Da
• Isoelectric Point: 9.6692

>NTDB_id=326925 EHF40_RS06915 WP_002983824.1 1314529..1315566(-) (sepM) [Streptococcus pyogenes strain Duke-Large]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTIQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=326925 EHF40_RS06915 WP_002983824.1 1314529..1315566(-) (sepM) [Streptococcus pyogenes strain Duke-Large]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGATTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9C0Q7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	68.986	100	0.69