Detailed information NTG0326018

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: EGX80_RS01385
• Genome accession: NZ_CP033815
• Coordinates: 252239..253276 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain FDAARGOS_514
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 247239..258276

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EGX80_RS01365 (EGX80_01365)	-	247989..248615 (+)	627	WP_002989076.1	A24 family peptidase	-
EGX80_RS01370 (EGX80_01370)	rlmN	248697..249776 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
EGX80_RS01375 (EGX80_01375)	-	249780..250400 (-)	621	WP_002992791.1	YutD family protein	-
EGX80_RS01380 (EGX80_01380)	-	250848..251825 (-)	978	WP_011054718.1	LacI family DNA-binding transcriptional regulator	-
EGX80_RS01385 (EGX80_01385)	sepM	252239..253276 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
EGX80_RS01390 (EGX80_01390)	coaD	253263..253754 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
EGX80_RS01395 (EGX80_01395)	rsmD	253744..254283 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
EGX80_RS01400 (EGX80_01400)	asnA	254406..255398 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
EGX80_RS01405 (EGX80_01405)	arcC	255711..256661 (-)	951	WP_003051912.1	carbamate kinase	-
EGX80_RS01410 (EGX80_01410)	-	256681..258012 (-)	1332	WP_011054719.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=326018 EGX80_RS01385 WP_010922499.1 252239..253276(-) (sepM) [Streptococcus pyogenes strain FDAARGOS_514]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=326018 EGX80_RS01385 WP_010922499.1 252239..253276(-) (sepM) [Streptococcus pyogenes strain FDAARGOS_514]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693