Detailed information NTG0326002

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: EGX85_RS11400
• Genome accession: NZ_CP033814
• Coordinates: 2296075..2297121 (+)
• Length: 348 a.a.
• NCBI ID: WP_011275375.1
• Uniprot ID: A0A2A1K920
• Organism: Staphylococcus haemolyticus strain FDAARGOS_517
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2291075..2302121

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EGX85_RS11375 (EGX85_11400)	map	2291935..2292687 (+)	753	WP_011275369.1	type I methionyl aminopeptidase	-
EGX85_RS11380 (EGX85_11405)	-	2292812..2293669 (-)	858	WP_011275370.1	SDR family oxidoreductase	-
EGX85_RS11385 (EGX85_11410)	-	2293741..2294753 (-)	1013	Protein_2214	HoxN/HupN/NixA family nickel/cobalt transporter	-
EGX85_RS11390 (EGX85_11415)	-	2294966..2295352 (+)	387	WP_011275373.1	hypothetical protein	-
EGX85_RS11395 (EGX85_11420)	liaF	2295377..2296078 (+)	702	WP_011275374.1	cell wall-active antibiotics response protein LiaF	-
EGX85_RS11400 (EGX85_11425)	vraS	2296075..2297121 (+)	1047	WP_011275375.1	sensor histidine kinase	Regulator
EGX85_RS11405 (EGX85_11430)	vraR	2297111..2297740 (+)	630	WP_011275376.1	two-component system response regulator VraR	Regulator
EGX85_RS11410 (EGX85_11435)	-	2297804..2299015 (-)	1212	WP_011275377.1	YihY/virulence factor BrkB family protein	-
EGX85_RS11415 (EGX85_11440)	-	2299212..2299496 (-)	285	WP_126116878.1	YtxH domain-containing protein	-
EGX85_RS11420 (EGX85_11445)	-	2299502..2299966 (-)	465	WP_011275379.1	low molecular weight protein-tyrosine-phosphatase	-
EGX85_RS11425 (EGX85_11450)	-	2300108..2300317 (+)	210	WP_011275380.1	DUF1128 domain-containing protein	-
EGX85_RS11430 (EGX85_11455)	-	2300331..2301578 (+)	1248	WP_011275381.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40179.58 Da
• Isoelectric Point: 6.0550

>NTDB_id=326002 EGX85_RS11400 WP_011275375.1 2296075..2297121(+) (vraS) [Staphylococcus haemolyticus strain FDAARGOS_517]
MNHYLRAIGSMLILVYSMLTAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLVIILLCIIVGSILAYKINQQNQWIKS
QIEHAIEGETVGINDQNIELYNETIDLYQTLVPLNQELHRLRMKTQNLTNENYNMNDVKVKKIIENERQRLARELHDSVS
QQLFAASMMLSAIKETKLEAPLDQQIPVLEKMVQESQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVIHDI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQQDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNREDDNNDD

Nucleotide

• Length: 1047 bp

>NTDB_id=326002 EGX85_RS11400 WP_011275375.1 2296075..2297121(+) (vraS) [Staphylococcus haemolyticus strain FDAARGOS_517]
ATGAACCACTACTTAAGAGCTATCGGTTCAATGCTTATACTAGTTTATAGCATGTTAACCGCGTTCTTATTTATAGATAA
AGTATTTGTTAATATTATCTATTTCCAAGGTATGTTTTATACTCAAATTTTTGGGATACCTGTTTTTCTATTTTTAAATT
TAGTCATCATTTTACTTTGTATTATAGTAGGTTCAATTCTCGCATATAAAATTAATCAACAAAATCAGTGGATTAAGTCG
CAAATTGAGCATGCCATTGAAGGAGAAACAGTAGGTATCAATGATCAAAACATTGAGCTCTATAACGAAACCATAGATCT
TTATCAAACATTAGTTCCTCTAAATCAAGAGTTGCACCGTTTACGAATGAAAACGCAAAACTTAACTAATGAAAATTACA
ATATGAATGATGTCAAAGTTAAGAAAATCATTGAGAATGAACGACAGAGATTAGCTCGCGAGTTACATGACTCTGTAAGT
CAACAACTTTTTGCAGCAAGTATGATGTTATCTGCTATAAAAGAAACAAAATTAGAGGCACCGCTTGATCAACAAATACC
AGTTTTAGAGAAAATGGTTCAGGAATCTCAACTTGAAATGCGCGCATTATTACTTCATTTGAGACCTTTAGGACTAAAAG
ATAAATCACTAGGTGAAGGTATCAAAGATTTAGTTATTGATTTGCAAAAGAAAGTGCCTATGAAAGTCATACACGATATT
CAAGATTTCAAGGTTCCTAAAGGTATAGAAGATCATTTATTTAGAATTACACAAGAGGCTATATCAAATACGTTAAGACA
TTCTAATGGAACTAAAGTCACAGTGGAATTATTTAACCAACAAGATTATCTATTACTTCGAATTCAAGATAATGGTAAGG
GATTCAATGTTGACGAGAAATTAGAACAAAGTTATGGATTAAAAAATATGAGAGAACGCGCATTAGAAATTGGTGCGACA
TTCCATATTGTTTCGTTACCGGATTCTGGAACGAGAATAGAAGTTAAAGCACCATTAAATAGGGAGGATGATAATAATGA
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase (HisKA_3) (147-210)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

3D structure

• AlphaFold DB: A0A2A1K920

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	91.643	99.713	0.914