Detailed information NTG0325520

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: EGX78_RS06440
• Genome accession: NZ_CP033767
• Coordinates: 1244028..1245065 (-)
• Length: 345 a.a.
• NCBI ID: WP_002989068.1
• Uniprot ID: Q1JKX2
• Organism: Streptococcus pyogenes strain FDAARGOS_534
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1239028..1250065

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EGX78_RS06415 (EGX78_06420)	-	1239032..1239559 (-)	528	WP_002983837.1	Dps family protein	-
EGX78_RS06420 (EGX78_06425)	-	1239787..1240413 (+)	627	WP_002989076.1	A24 family peptidase	-
EGX78_RS06425 (EGX78_06430)	rlmN	1240495..1241574 (-)	1080	WP_002989074.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
EGX78_RS06430 (EGX78_06435)	-	1241578..1242198 (-)	621	WP_032461520.1	YutD family protein	-
EGX78_RS06435 (EGX78_06440)	-	1242646..1243623 (-)	978	WP_002989070.1	LacI family DNA-binding transcriptional regulator	-
EGX78_RS06440 (EGX78_06445)	sepM	1244028..1245065 (-)	1038	WP_002989068.1	SepM family pheromone-processing serine protease	Regulator
EGX78_RS06445 (EGX78_06450)	coaD	1245052..1245543 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
EGX78_RS06450 (EGX78_06455)	rsmD	1245533..1246072 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
EGX78_RS06455 (EGX78_06460)	asnA	1246195..1247187 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
EGX78_RS06460 (EGX78_06465)	arcC	1247501..1248451 (-)	951	WP_002989065.1	carbamate kinase	-
EGX78_RS06465 (EGX78_06470)	-	1248471..1249802 (-)	1332	WP_002989063.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37527.17 Da
• Isoelectric Point: 9.5788

>NTDB_id=325520 EGX78_RS06440 WP_002989068.1 1244028..1245065(-) (sepM) [Streptococcus pyogenes strain FDAARGOS_534]
MKRLNKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=325520 EGX78_RS06440 WP_002989068.1 1244028..1245065(-) (sepM) [Streptococcus pyogenes strain FDAARGOS_534]
ATGAAAAGACTTAACAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAG

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: Q1JKX2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	68.986	100	0.69