Detailed information    

insolico Bioinformatically predicted

Overview

Name   comYH   Type   Machinery gene
Locus tag   EGX78_RS00835 Genome accession   NZ_CP033767
Coordinates   133051..134004 (+) Length   317 a.a.
NCBI ID   WP_002987790.1    Uniprot ID   A0A5S4TCX5
Organism   Streptococcus pyogenes strain FDAARGOS_534     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 128051..139004
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EGX78_RS00795 (EGX78_00795) - 128878..129243 (+) 366 WP_002986560.1 DUF1033 family protein -
  EGX78_RS00800 (EGX78_00800) comYA 129336..130274 (+) 939 WP_002987773.1 competence type IV pilus ATPase ComGA Machinery gene
  EGX78_RS00805 (EGX78_00805) comYB 130210..131244 (+) 1035 WP_223845212.1 competence type IV pilus assembly protein ComGB Machinery gene
  EGX78_RS00810 (EGX78_00810) comYC 131246..131572 (+) 327 WP_002986552.1 competence type IV pilus major pilin ComGC Machinery gene
  EGX78_RS00815 (EGX78_00815) comGD 131547..131975 (+) 429 WP_002986548.1 competence type IV pilus minor pilin ComGD -
  EGX78_RS00820 (EGX78_00820) comGE 131932..132216 (+) 285 WP_002987779.1 competence type IV pilus minor pilin ComGE -
  EGX78_RS00825 (EGX78_00825) comYF 132209..132643 (+) 435 WP_002987783.1 competence type IV pilus minor pilin ComGF Machinery gene
  EGX78_RS00830 (EGX78_00830) comGG 132627..132953 (+) 327 WP_002987787.1 competence type IV pilus minor pilin ComGG -
  EGX78_RS00835 (EGX78_00835) comYH 133051..134004 (+) 954 WP_002987790.1 class I SAM-dependent methyltransferase Machinery gene
  EGX78_RS00840 (EGX78_00840) - 134063..135259 (+) 1197 WP_123949427.1 acetate kinase -
  EGX78_RS00845 (EGX78_00845) - 135446..135754 (+) 309 WP_032461811.1 hypothetical protein -
  EGX78_RS00850 (EGX78_00850) proC 135837..136607 (-) 771 WP_002986527.1 pyrroline-5-carboxylate reductase -
  EGX78_RS00855 (EGX78_00855) pepA 136655..137722 (-) 1068 WP_002987798.1 glutamyl aminopeptidase -
  EGX78_RS00865 (EGX78_00865) - 138187..138468 (+) 282 WP_024623420.1 DUF4651 domain-containing protein -
  EGX78_RS00870 (EGX78_00870) - 138468..138785 (+) 318 WP_002987805.1 thioredoxin family protein -

Sequence

Protein


Download         Length: 317 a.a.        Molecular weight: 35985.08 Da        Isoelectric Point: 4.7205

>NTDB_id=325492 EGX78_RS00835 WP_002987790.1 133051..134004(+) (comYH) [Streptococcus pyogenes strain FDAARGOS_534]
MTFEKIEEAYQLLLENCQLIENDLKTHIYDAIVEQNSFYLGAEGASPQVAQNSDKLKALCLTKEEWRKAYQFLFIKAAQT
EQLQANHQFTPDAIGFILLYLLEQLSDKDSLEVLEIGSGTGNLAQTLLNNTSKSLDYVGIELDDLLIDLSASIAEIMDSS
AHFIQEDAVRPQLLKESDIVISDLPVGYYPNDDIAKRYKVASSDKHTYAHHLLMEQSLKYLKKDGFAIFLAPVNLLTSPQ
SQLLKQWLKDYAQVVALITLPDSIFGHPSNAKSIIVLQKQTDHPMETFVYPIRDLKLAENIHDFMENFKKWKLSNVN

Nucleotide


Download         Length: 954 bp        

>NTDB_id=325492 EGX78_RS00835 WP_002987790.1 133051..134004(+) (comYH) [Streptococcus pyogenes strain FDAARGOS_534]
ATGACTTTTGAAAAAATTGAAGAAGCTTATCAGCTGCTCTTAGAGAACTGTCAACTAATTGAAAATGATCTAAAAACACA
TATATACGATGCCATTGTTGAACAAAACTCCTTTTATTTAGGGGCTGAGGGAGCTAGTCCTCAAGTTGCTCAAAATAGTG
ATAAACTGAAAGCCTTGTGCCTGACAAAAGAAGAATGGCGTAAGGCCTACCAGTTTCTTTTTATTAAGGCAGCTCAGACT
GAGCAACTCCAAGCCAACCATCAGTTCACACCAGATGCTATTGGCTTCATTCTGCTGTATCTTTTGGAACAATTGAGTGA
TAAAGATAGCTTAGAGGTACTTGAGATTGGAAGTGGAACAGGGAACCTAGCCCAAACCCTTCTCAACAACACGAGCAAGA
GCCTTGATTATGTAGGGATTGAACTTGATGATCTCTTGATTGATCTGTCAGCCAGTATTGCTGAGATAATGGATTCTTCA
GCTCATTTTATTCAAGAAGATGCGGTAAGGCCTCAATTACTAAAAGAAAGTGACATTGTCATCAGTGACTTACCAGTTGG
TTATTATCCTAACGATGATATTGCCAAACGGTACAAGGTGGCTAGTTCAGATAAGCATACCTATGCCCATCATTTATTAA
TGGAACAGTCTTTAAAATACTTGAAAAAAGACGGTTTTGCGATTTTTCTGGCACCAGTCAATTTATTGACGAGCCCTCAG
AGTCAGTTATTGAAACAGTGGTTAAAAGATTATGCTCAGGTGGTGGCCTTGATTACGCTACCAGATTCTATTTTTGGTCA
TCCCTCAAATGCCAAGTCCATTATTGTCTTACAAAAACAAACAGACCACCCAATGGAAACCTTTGTCTATCCAATTCGGG
ATTTGAAGCTTGCAGAGAATATTCATGATTTTATGGAAAATTTCAAAAAATGGAAACTGAGTAATGTCAATTAA

Domains

Predicted by InterproScan.

N-6 DNA Methylase (N6_Mtase)

(68-288)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A5S4TCX5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comYH Streptococcus mutans UA159

66.139

99.685

0.659
  comYH Streptococcus mutans UA140

65.823

99.685

0.656

Multiple sequence alignment