Detailed information NTG0324313

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: EFD52_RS02515
• Genome accession: NZ_CP033606
• Coordinates: 483403..485649 (+)
• Length: 748 a.a.
• NCBI ID: WP_003130823.1
• Uniprot ID: A0A269YWG7
• Organism: Lactococcus lactis strain IL6288
• Function: degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 478403..490649

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EFD52_RS02495 (EFD52_02495)	rpoD	478998..480341 (+)	1344	WP_003130829.1	RNA polymerase sigma factor RpoD	-
EFD52_RS02500 (EFD52_02500)	-	480456..481199 (+)	744	WP_010905438.1	MurR/RpiR family transcriptional regulator	-
EFD52_RS02505 (EFD52_02505)	-	481364..482731 (+)	1368	WP_003130826.1	MFS transporter	-
EFD52_RS02510 (EFD52_02510)	-	483014..483352 (+)	339	WP_003130824.1	hypothetical protein	-
EFD52_RS02515 (EFD52_02515)	clpC	483403..485649 (+)	2247	WP_003130823.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
EFD52_RS02520 (EFD52_02520)	-	486071..486541 (-)	471	WP_010905440.1	Rrf2 family transcriptional regulator	-
EFD52_RS02525 (EFD52_02525)	gap	486714..487727 (+)	1014	WP_003130818.1	type I glyceraldehyde-3-phosphate dehydrogenase	-
EFD52_RS02530 (EFD52_02530)	def	487870..488505 (-)	636	WP_003130816.1	peptide deformylase	-
EFD52_RS02535 (EFD52_02535)	-	488653..489114 (+)	462	WP_306171264.1	RNA pyrophosphohydrolase	-

Sequence

Protein

• Length: 748 a.a.
• Molecular weight: 83144.87 Da
• Isoelectric Point: 4.7623

>NTDB_id=324313 EFD52_RS02515 WP_003130823.1 483403..485649(+) (clpC) [Lactococcus lactis strain IL6288]
MLCQNCNINEATIHLYTSVNGQKKQIDLCQNCYQIMKSGGQEALFGAGNASNGNSDEPFNPFNDIFSALHGQDFNGAAST
QTPPTQTGGRGPRGPQNPRAKQPKGMLEEFGINITESARRGEIDPVIGRDEEIKRVIEILNRRTKNNPVLIGEPGVGKTA
VVEGLAQKIVDGDVPQKLQNKEVIRLDVVSLVQGTGIRGQFEERMQKLMDEIRKRNDVIMFIDEIHEIVGAGSAGDGNMD
AGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPSVDETITILRGIQARYEDYHHVKYTDEAIEAAAH
LSNRYIQDRFLPDKAIDLLDESGSKKNLTLKFVDPEDINRRIADAETKKNEATQAEDFEKAAHFRDQITKLRELQNHEVS
DDEIPVITEKDIEQIVEQKTHIPVGDLKEKEQTQLINLADDLKAHVIGQDEAVDKIAKAIRRSRVGLGKPNRPIGSFLFV
GPTGVGKTELAKQLAKELFGSSESMIRFDMSEYMEKHSVAKLIGAPPGYVGYEEAGQLTERVRRNPYSLILLDEIEKAHP
DVMHMFLQILEDGRLTDAQGRTVSFKDSLIIMTSNAGTGKVEASVGFGAAREGRTKSVLGQLGDFFSPEFMNRFDGIIEF
SALSKENLLKIVDLMLDEVNEQIGRNDIHLSVTQAAKEKLVDLGYNPAMGARPLRRTIQENIEDSIADFYIEHPEYKELV
ADLIDDKIVISNQAQETAETTDEEVPAE

Nucleotide

• Length: 2247 bp

>NTDB_id=324313 EFD52_RS02515 WP_003130823.1 483403..485649(+) (clpC) [Lactococcus lactis strain IL6288]
ATGCTTTGTCAAAATTGTAATATTAATGAAGCGACGATTCACCTTTACACAAGTGTAAATGGTCAGAAAAAACAAATTGA
TTTGTGCCAAAACTGTTATCAAATTATGAAATCTGGCGGTCAAGAAGCTTTATTTGGCGCAGGAAATGCCTCAAATGGAA
ATTCTGATGAACCATTTAATCCATTTAATGATATCTTTAGTGCTTTGCACGGTCAAGATTTTAATGGAGCAGCAAGCACT
CAAACTCCACCAACACAAACAGGTGGACGTGGTCCGCGAGGTCCACAAAATCCTCGGGCAAAACAACCTAAAGGAATGTT
AGAAGAATTTGGAATTAACATCACAGAGTCAGCTCGTCGTGGCGAAATTGACCCAGTGATTGGGCGTGATGAAGAAATTA
AACGTGTCATTGAGATTTTAAATCGTAGGACTAAGAATAATCCTGTATTAATTGGTGAACCTGGTGTTGGTAAAACAGCA
GTTGTTGAAGGTTTAGCGCAAAAAATTGTGGACGGAGATGTGCCGCAAAAACTACAAAATAAAGAAGTGATTCGTCTTGA
TGTTGTTTCTCTTGTTCAAGGAACAGGAATTCGTGGACAATTTGAAGAACGGATGCAAAAATTAATGGATGAAATCAGAA
AACGTAATGATGTGATTATGTTTATTGATGAAATTCATGAAATTGTTGGTGCTGGTTCTGCCGGTGATGGCAATATGGAT
GCAGGAAATATCCTAAAACCTGCGCTTGCGCGTGGTGAGCTTCAATTGGTCGGAGCAACAACGCTCAATGAATATCGCAT
CATTGAAAAAGATGCTGCGCTTGAACGCCGGATGCAACCAGTTAAAGTCGATGAACCATCAGTTGATGAAACAATTACTA
TTTTGCGAGGCATTCAAGCACGTTATGAAGATTATCATCATGTGAAATACACTGATGAGGCTATTGAAGCAGCCGCTCAT
TTGTCAAATCGTTACATTCAAGACCGTTTCTTACCAGATAAAGCCATTGACCTTTTGGATGAGTCTGGTTCTAAGAAAAA
TCTAACCTTGAAATTTGTTGATCCTGAAGATATTAATCGTCGGATTGCGGATGCAGAAACGAAGAAAAATGAAGCAACAC
AGGCTGAAGATTTTGAAAAAGCCGCTCATTTCCGTGACCAAATCACTAAACTTCGTGAATTACAAAATCATGAAGTTTCA
GATGATGAAATTCCTGTCATCACTGAAAAAGATATTGAACAAATTGTTGAGCAAAAAACACATATTCCAGTTGGTGATTT
GAAAGAAAAAGAACAAACCCAATTGATTAATTTGGCTGATGATTTGAAAGCACATGTGATTGGTCAGGATGAAGCAGTGG
ATAAGATTGCTAAAGCTATCCGTCGTTCTCGTGTGGGACTTGGTAAACCTAATCGTCCAATTGGTTCTTTCCTTTTCGTT
GGTCCAACAGGTGTTGGTAAAACAGAACTTGCTAAACAATTGGCTAAAGAATTATTTGGCTCAAGTGAAAGTATGATTCG
TTTTGACATGTCGGAATACATGGAAAAACATTCGGTGGCCAAATTGATTGGAGCCCCTCCAGGATATGTGGGTTATGAAG
AAGCTGGTCAATTGACTGAACGTGTTCGTCGTAATCCCTACAGTTTGATTTTATTAGATGAAATCGAAAAAGCACATCCA
GATGTGATGCACATGTTCTTGCAAATTCTTGAAGATGGACGTCTGACAGACGCACAAGGACGGACAGTATCCTTTAAAGA
TAGTTTGATTATTATGACTTCTAATGCCGGAACTGGTAAAGTTGAAGCCTCTGTCGGATTTGGTGCTGCTCGTGAGGGAC
GAACTAAATCAGTGCTTGGTCAGCTTGGCGATTTCTTTAGCCCTGAATTCATGAACCGTTTTGACGGAATAATTGAATTC
TCTGCTTTGAGCAAAGAAAATCTCCTTAAAATTGTTGATTTGATGCTTGATGAAGTCAACGAACAAATTGGACGTAATGA
TATTCATCTTAGTGTCACTCAAGCAGCAAAAGAAAAATTAGTTGATTTAGGTTACAATCCAGCAATGGGTGCTAGACCAC
TTCGTAGAACAATTCAAGAAAATATCGAAGATTCAATTGCTGACTTCTATATTGAACACCCTGAATACAAAGAATTGGTT
GCTGATTTGATTGATGATAAAATTGTTATCTCTAATCAAGCTCAAGAAACAGCAGAAACGACTGATGAAGAAGTTCCTGC
TGAATAA

Domains

Predicted by InterproScan.

• AAA lid domain (AAA_lid_9) (287-386)

• ATPase family associated with various cellular activities (AAA) (AAA) (149-268)

• AAA domain (Cdc48 subfamily) (AAA_2) (472-635)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (643-713)

3D structure

• AlphaFold DB: A0A269YWG7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Lactococcus lactis subsp. cremoris KW2	97.995	100	0.98
clpE	Streptococcus mutans UA159	76.026	100	0.767
clpE	Streptococcus pneumoniae Rx1	75.543	98.396	0.743
clpE	Streptococcus pneumoniae D39	75.543	98.396	0.743
clpE	Streptococcus pneumoniae R6	75.543	98.396	0.743
clpE	Streptococcus pneumoniae TIGR4	75.543	98.396	0.743
clpC	Bacillus subtilis subsp. subtilis str. 168	51.672	87.968	0.455
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	47.635	81.952	0.39
clpC	Streptococcus pneumoniae Rx1	46.635	83.422	0.389
clpC	Streptococcus pneumoniae D39	46.635	83.422	0.389
clpC	Streptococcus pneumoniae TIGR4	46.635	83.422	0.389
clpC	Streptococcus thermophilus LMD-9	46.104	82.353	0.38
clpC	Streptococcus thermophilus LMG 18311	45.942	82.353	0.378
clpC	Streptococcus mutans UA159	45.631	82.62	0.377