Detailed information NTG0323140

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: EB816_RS06825
• Genome accession: NZ_CP033337
• Coordinates: 1317606..1318643 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain TSPY453
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1312606..1323643

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EB816_RS06805 (EB816_06805)	-	1313357..1313983 (+)	627	WP_010922497.1	A24 family peptidase	-
EB816_RS06810 (EB816_06810)	rlmN	1314065..1315144 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
EB816_RS06815 (EB816_06815)	-	1315148..1315768 (-)	621	WP_002992791.1	YutD family protein	-
EB816_RS06820 (EB816_06820)	-	1316216..1317193 (-)	978	WP_023612501.1	LacI family DNA-binding transcriptional regulator	-
EB816_RS06825 (EB816_06825)	sepM	1317606..1318643 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
EB816_RS06830 (EB816_06830)	coaD	1318630..1319121 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
EB816_RS06835 (EB816_06835)	rsmD	1319111..1319650 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
EB816_RS06840 (EB816_06840)	asnA	1319773..1320765 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
EB816_RS06845 (EB816_06845)	arcC	1321078..1322028 (-)	951	WP_015057899.1	carbamate kinase	-
EB816_RS06850 (EB816_06850)	-	1322048..1323379 (-)	1332	WP_023612508.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=323140 EB816_RS06825 WP_010922499.1 1317606..1318643(-) (sepM) [Streptococcus pyogenes strain TSPY453]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=323140 EB816_RS06825 WP_010922499.1 1317606..1318643(-) (sepM) [Streptococcus pyogenes strain TSPY453]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693