Detailed information NTG0323139

Bioinformatically predicted

Overview

• Name: clpE
• Type: Regulator
• Locus tag: EB816_RS06705
• Genome accession: NZ_CP033337
• Coordinates: 1291891..1294173 (+)
• Length: 760 a.a.
• NCBI ID: WP_023612514.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain TSPY453
• Function: repress competence development (at the early growth phase) (predicted from homology) Competence regulation

Genomic Context

Location: 1286891..1299173

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EB816_RS06685 (EB816_06685)	-	1288258..1289667 (-)	1410	WP_023612511.1	deoxyribodipyrimidine photo-lyase	-
EB816_RS06690 (EB816_06690)	-	1289816..1290550 (-)	735	WP_023612489.1	amino acid ABC transporter ATP-binding protein	-
EB816_RS06695 (EB816_06695)	-	1290550..1291236 (-)	687	WP_011054708.1	amino acid ABC transporter permease	-
EB816_RS06700 (EB816_06700)	-	1291363..1291593 (-)	231	WP_002983885.1	YkuJ family protein	-
EB816_RS06705 (EB816_06705)	clpE	1291891..1294173 (+)	2283	WP_023612514.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
EB816_RS06710 (EB816_06710)	-	1294301..1294753 (+)	453	WP_023612526.1	NUDIX hydrolase	-
EB816_RS06715 (EB816_06715)	-	1294808..1295110 (+)	303	WP_010922490.1	DUF1827 family protein	-
EB816_RS06720 (EB816_06720)	ileS	1295375..1298176 (-)	2802	WP_023612524.1	isoleucine--tRNA ligase	-

Sequence

Protein

• Length: 760 a.a.
• Molecular weight: 84702.88 Da
• Isoelectric Point: 5.0123

>NTDB_id=323139 EB816_RS06705 WP_023612514.1 1291891..1294173(+) (clpE) [Streptococcus pyogenes strain TSPY453]
MLCQNCNLNESTIHLYTSVNGKQRQVDLCQNCYQIMKSDPANSILNGLTPGYRAQDRSTSPFFDDFFGDLNNFRAFGNLP
NTPPTQAGQNGNGGGRYGGNYNGQRPAQPQTPNQQAKGLLEEFGINVTDIARNGNIDPVIGRDEEITRVIEILNRRTKNN
PVLIGEPGVGKTAVVEGLAQKIIDGTVPQKLQGKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRNRKDVILFIDEIHE
IVGAGSAGDGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPSVEETITILKGIQPKYEDYHH
VKYSPAAIEAAAHLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKEIDKRLIEAENLKAQATRDEDYERAAYFRDQ
IAKYKEMQAQKVDEQDIPIITEKTIEAIIEQKTNIPVGDLKEKEQSQLVNLANDLKAHVIGQDDAVDKIAKAIRRNRVGL
GTPNRPIGSFLFVGPTGVGKTELSKQLAIELFGSTNNMIRFDMSEYMEKHAVAKLVGAPPGYVGYEEAGQLTEQVRRNPY
SLILLDEVEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKSEASVGFGAAREGRTSSVLGELSNFFS
PEFMNRFDGIIEFKALSKEHLLHIVDLMLEDVNERLGYNGIHLDVTQKVKEKLVDLGYDPKMGARPLRRTIQDYIEDAIT
DYYLEHPTEKQLRALMTNSENITIKAVKEGDSFLNEESLD

Nucleotide

• Length: 2283 bp

>NTDB_id=323139 EB816_RS06705 WP_023612514.1 1291891..1294173(+) (clpE) [Streptococcus pyogenes strain TSPY453]
ATGCTGTGTCAAAATTGTAATTTAAACGAATCTACTATTCATCTTTATACAAGTGTTAATGGAAAACAAAGACAGGTTGA
TCTCTGTCAAAATTGTTATCAAATCATGAAATCCGATCCTGCCAATTCTATTTTAAATGGCTTAACCCCAGGATATAGAG
CACAAGATAGATCCACAAGTCCTTTCTTTGATGACTTTTTTGGTGATTTGAATAATTTTAGAGCTTTTGGTAATCTTCCA
AATACCCCACCTACTCAGGCAGGGCAAAATGGAAATGGCGGAGGACGCTATGGTGGTAACTACAACGGACAACGACCTGC
TCAGCCACAAACACCAAATCAGCAAGCAAAGGGCTTGTTAGAAGAGTTTGGGATTAATGTCACAGATATTGCAAGAAATG
GTAATATTGATCCTGTTATTGGTCGTGACGAAGAGATTACACGCGTTATCGAGATCCTCAACCGCCGTACTAAAAATAAT
CCTGTGCTAATTGGTGAGCCTGGAGTTGGTAAAACTGCTGTTGTAGAAGGTTTGGCTCAAAAAATTATTGATGGTACTGT
TCCTCAAAAACTCCAAGGCAAGCAAGTGATTCGTCTTGATGTGGTTAGCCTCGTTCAGGGAACAGGTATCCGTGGTCAGT
TTGAAGAGCGCATGCAAAAATTAATGGAAGAAATTCGCAATCGCAAGGATGTGATTCTCTTTATTGATGAAATTCATGAG
ATTGTCGGTGCTGGTTCTGCAGGAGACGGCAATATGGATGCTGGTAATATTTTAAAACCAGCCTTGGCCCGTGGTGAGTT
GCAGTTGGTCGGCGCTACCACCTTAAATGAATACCGTATTATTGAAAAAGATGCTGCCTTGGAGCGACGTATGCAACCCG
TTAAAGTTGATGAACCTTCTGTTGAGGAAACCATCACGATTTTAAAAGGTATCCAACCGAAATACGAAGACTATCATCAT
GTCAAATATAGCCCAGCCGCTATTGAAGCTGCCGCTCATTTATCTAACCGCTATATTCAAGACCGTTTTCTTCCTGATAA
GGCTATTGACCTTCTGGACGAAGCTGGTTCCAAAATGAATCTAACCCTCAACTTTGTTGATCCTAAAGAAATTGACAAAC
GTCTTATTGAAGCTGAGAATCTCAAGGCGCAAGCTACTCGAGACGAAGACTATGAACGCGCAGCTTATTTCCGCGATCAA
ATTGCGAAATACAAGGAAATGCAGGCTCAAAAAGTCGATGAGCAAGATATTCCTATCATTACTGAAAAAACCATTGAAGC
CATCATTGAACAAAAAACCAATATTCCAGTTGGCGACTTGAAAGAAAAAGAACAATCTCAACTCGTAAACTTAGCCAATG
ATCTGAAAGCACACGTGATCGGGCAAGACGATGCTGTTGATAAAATCGCTAAGGCTATTCGTCGTAACCGTGTGGGATTA
GGAACTCCAAATCGCCCTATTGGTTCTTTCTTATTCGTTGGACCGACTGGGGTTGGTAAAACTGAATTGTCTAAACAACT
AGCCATTGAACTCTTTGGTTCGACAAACAATATGATTCGCTTTGACATGTCCGAATACATGGAAAAACACGCTGTCGCCA
AATTAGTCGGGGCTCCTCCAGGTTATGTCGGCTATGAAGAAGCTGGACAGCTAACCGAACAAGTTCGTCGCAATCCTTAT
TCCCTTATTCTCTTAGATGAGGTGGAAAAAGCCCATCCTGACGTCATGCACATGTTCTTACAAGTTCTTGATGACGGTCG
CTTAACAGACGGCCAAGGGCGAACAGTCAGCTTCAAGGACACCATTATTATCATGACCTCTAATGCCGGAACAGGTAAAA
GCGAAGCTTCTGTCGGATTTGGTGCTGCTAGAGAAGGACGGACAAGTTCTGTCCTTGGTGAATTAAGCAACTTCTTCAGC
CCAGAGTTTATGAATCGTTTCGATGGTATTATTGAATTCAAAGCTTTATCTAAAGAACATTTGCTGCATATCGTTGATTT
AATGCTGGAAGATGTTAATGAGCGCTTAGGCTATAATGGGATTCATCTTGATGTGACACAAAAGGTCAAAGAAAAATTAG
TAGATTTAGGCTATGATCCTAAAATGGGCGCTCGGCCGCTCCGTCGTACTATCCAAGATTATATCGAAGATGCCATTACA
GACTATTATTTAGAACACCCAACTGAAAAACAGTTACGTGCACTGATGACAAACAGTGAAAACATCACGATTAAAGCTGT
TAAAGAGGGAGATTCTTTTCTTAACGAAGAGTCTCTAGATTAA

Domains

Predicted by InterproScan.

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (656-729)

• AAA lid domain (AAA_lid_9) (300-397)

• ATPase family associated with various cellular activities (AAA) (AAA) (162-281)

• AAA domain (Cdc48 subfamily) (AAA_2) (485-648)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpE	Streptococcus mutans UA159	84.759	98.421	0.834
clpE	Streptococcus pneumoniae Rx1	82.956	98.816	0.82
clpE	Streptococcus pneumoniae D39	82.956	98.816	0.82
clpE	Streptococcus pneumoniae R6	82.956	98.816	0.82
clpE	Streptococcus pneumoniae TIGR4	82.823	98.816	0.818
clpC	Lactococcus lactis subsp. cremoris KW2	75.033	100	0.751
clpC	Bacillus subtilis subsp. subtilis str. 168	51.138	86.711	0.443
clpC	Streptococcus pneumoniae D39	48	82.237	0.395
clpC	Streptococcus pneumoniae Rx1	48	82.237	0.395
clpC	Streptococcus pneumoniae TIGR4	48	82.237	0.395
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	46	85.526	0.393
clpC	Streptococcus mutans UA159	47.573	81.316	0.387
clpC	Streptococcus thermophilus LMD-9	47.115	82.105	0.387
clpC	Streptococcus thermophilus LMG 18311	46.795	82.105	0.384