Detailed information    

insolico Bioinformatically predicted

Overview

Name   comR   Type   Regulator
Locus tag   EB816_RS00335 Genome accession   NZ_CP033337
Coordinates   52873..53784 (+) Length   303 a.a.
NCBI ID   WP_002986681.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain TSPY453     
Function   activate transcription of comX (predicted from homology)   
Competence regulation

Genomic Context

Location: 47873..58784
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EB816_RS00315 (EB816_00315) purE 48459..48950 (+) 492 WP_023612097.1 5-(carboxyamino)imidazole ribonucleotide mutase -
  EB816_RS00320 (EB816_00320) purK 48937..50010 (+) 1074 WP_164977033.1 5-(carboxyamino)imidazole ribonucleotide synthase -
  EB816_RS00325 (EB816_00325) - 50012..51430 (+) 1419 WP_129256656.1 hypothetical protein -
  EB816_RS00330 (EB816_00330) purB 51450..52742 (+) 1293 WP_023612104.1 adenylosuccinate lyase -
  EB816_RS00335 (EB816_00335) comR 52873..53784 (+) 912 WP_002986681.1 transcriptional regulator Rgg4/ComR Regulator
  EB816_RS00340 (EB816_00340) ruvB 54009..55007 (+) 999 WP_002986679.1 Holliday junction branch migration DNA helicase RuvB -
  EB816_RS00345 (EB816_00345) - 55145..55582 (+) 438 WP_002994668.1 low molecular weight phosphotyrosine protein phosphatase -
  EB816_RS00350 (EB816_00350) - 55605..56006 (+) 402 WP_002986671.1 MORN repeat-containing protein -
  EB816_RS00355 (EB816_00355) - 56003..57778 (+) 1776 WP_023612103.1 acyltransferase family protein -

Sequence

Protein


Download         Length: 303 a.a.        Molecular weight: 35757.27 Da        Isoelectric Point: 4.4858

>NTDB_id=323100 EB816_RS00335 WP_002986681.1 52873..53784(+) (comR) [Streptococcus pyogenes strain TSPY453]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide


Download         Length: 912 bp        

>NTDB_id=323100 EB816_RS00335 WP_002986681.1 52873..53784(+) (comR) [Streptococcus pyogenes strain TSPY453]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

Helix-turn-helix (HTH_3)

(12-64)

ComR tetratricopeptide (ComR_TPR)

(73-296)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR Streptococcus pyogenes MGAS8232

100

100

1
  comR Streptococcus pyogenes MGAS315

58.472

99.34

0.581
  comR Streptococcus infantarius subsp. infantarius ATCC BAA-102

51.37

96.37

0.495
  comR Streptococcus mutans UA159

46.358

99.67

0.462

Multiple sequence alignment