Detailed information NTG0323029

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: EB818_RS06310
• Genome accession: NZ_CP033335
• Coordinates: 1228701..1229738 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain TSPY208
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1223701..1234738

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EB818_RS06290 (EB818_06300)	-	1224451..1225077 (+)	627	WP_002983834.1	A24 family peptidase	-
EB818_RS06295 (EB818_06305)	rlmN	1225159..1226238 (-)	1080	WP_129322734.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
EB818_RS06300 (EB818_06310)	-	1226242..1226862 (-)	621	WP_002992791.1	YutD family protein	-
EB818_RS06305 (EB818_06315)	-	1227310..1228287 (-)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
EB818_RS06310 (EB818_06320)	sepM	1228701..1229738 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
EB818_RS06315 (EB818_06325)	coaD	1229725..1230216 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
EB818_RS06320 (EB818_06330)	rsmD	1230206..1230745 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
EB818_RS06325 (EB818_06335)	asnA	1230868..1231860 (-)	993	WP_020905328.1	aspartate--ammonia ligase	-
EB818_RS06330 (EB818_06340)	arcC	1232173..1233123 (-)	951	WP_010922501.1	carbamate kinase	-
EB818_RS06335 (EB818_06345)	-	1233143..1234474 (-)	1332	WP_011054719.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=323029 EB818_RS06310 WP_010922499.1 1228701..1229738(-) (sepM) [Streptococcus pyogenes strain TSPY208]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=323029 EB818_RS06310 WP_010922499.1 1228701..1229738(-) (sepM) [Streptococcus pyogenes strain TSPY208]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGATGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693