Detailed information    

insolico Bioinformatically predicted

Overview

Name   pepF   Type   Regulator
Locus tag   EB818_RS05595 Genome accession   NZ_CP033335
Coordinates   1088804..1090609 (-) Length   601 a.a.
NCBI ID   WP_129322721.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain TSPY208     
Function   degradation of XIP; competence shut-off (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1068484..1098415 1088804..1090609 within 0


Gene organization within MGE regions


Location: 1068484..1098415
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EB818_RS05510 (EB818_05520) - 1068541..1069815 (-) 1275 WP_014407660.1 polysaccharide deacetylase family protein -
  EB818_RS05515 (EB818_05525) - 1069910..1071337 (-) 1428 WP_002984035.1 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase -
  EB818_RS05520 (EB818_05530) ptsP 1071522..1073255 (-) 1734 WP_002989245.1 phosphoenolpyruvate--protein phosphotransferase -
  EB818_RS05525 (EB818_05535) - 1073260..1073523 (-) 264 WP_002984031.1 phosphocarrier protein HPr -
  EB818_RS05530 (EB818_05540) - 1073908..1074126 (+) 219 WP_003051493.1 redoxin NrdH -
  EB818_RS05535 (EB818_05545) nrdE 1074146..1076305 (+) 2160 WP_129322719.1 class 1b ribonucleoside-diphosphate reductase subunit alpha -
  EB818_RS05540 (EB818_05550) nrdF 1076638..1077597 (+) 960 WP_011017933.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
  EB818_RS05545 (EB818_05555) - 1077572..1078885 (+) 1314 WP_014411846.1 chloride channel protein -
  EB818_RS05555 (EB818_05565) - 1079023..1080173 (+) 1151 Protein_1017 IS3 family transposase -
  EB818_RS05560 (EB818_05570) - 1080289..1080984 (-) 696 WP_011184658.1 type II CAAX endopeptidase family protein -
  EB818_RS05565 (EB818_05575) - 1081003..1081764 (-) 762 WP_020905286.1 DUF3169 family protein -
  EB818_RS05570 (EB818_05580) - 1081761..1081976 (-) 216 WP_002989220.1 helix-turn-helix transcriptional regulator -
  EB818_RS05575 (EB818_05585) alaS 1082336..1084954 (-) 2619 WP_129322720.1 alanine--tRNA ligase -
  EB818_RS05580 (EB818_05590) prsA 1085341..1086396 (-) 1056 WP_020905289.1 peptidylprolyl isomerase PrsA -
  EB818_RS05585 (EB818_05595) - 1086459..1087166 (-) 708 WP_002989211.1 O-methyltransferase -
  EB818_RS05590 (EB818_05600) - 1087232..1088428 (-) 1197 WP_002995765.1 OFA family MFS transporter -
  EB818_RS05595 (EB818_05605) pepF 1088804..1090609 (-) 1806 WP_129322721.1 oligoendopeptidase F Regulator
  EB818_RS05600 (EB818_05610) - 1090622..1091584 (-) 963 WP_002983995.1 competence protein CoiA -
  EB818_RS05605 (EB818_05615) - 1091881..1092597 (-) 717 WP_020905292.1 pseudouridine synthase -
  EB818_RS05610 (EB818_05620) nagB 1092716..1093420 (-) 705 WP_009880651.1 glucosamine-6-phosphate deaminase -
  EB818_RS05615 (EB818_05625) queA 1093622..1094650 (+) 1029 WP_076639300.1 tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA -
  EB818_RS05620 (EB818_05630) - 1094657..1095877 (+) 1221 WP_002983986.1 DUF3114 domain-containing protein -
  EB818_RS05625 (EB818_05635) - 1095991..1096813 (-) 823 Protein_1031 serine hydrolase -
  EB818_RS09160 - 1096868..1097023 (-) 156 WP_020905298.1 hypothetical protein -
  EB818_RS05635 (EB818_05645) sodA 1097185..1097790 (-) 606 WP_020905299.1 superoxide dismutase SodA -

Sequence

Protein


Download         Length: 601 a.a.        Molecular weight: 69350.20 Da        Isoelectric Point: 4.7406

>NTDB_id=323025 EB818_RS05595 WP_129322721.1 1088804..1090609(-) (pepF) [Streptococcus pyogenes strain TSPY208]
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEIDAAKDFSGHLLDSSANLLTITDTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMALSQEDYQAFLAETPDLKRYHHFFDKLFQTRDHVLSHAEEELLAGA
QEIFNGAEETFSILDNADIVFPVVKNDKGEDVELTHGNFISLMESKDRSIRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS

Nucleotide


Download         Length: 1806 bp        

>NTDB_id=323025 EB818_RS05595 WP_129322721.1 1088804..1090609(-) (pepF) [Streptococcus pyogenes strain TSPY208]
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAATTGACGCGGCTAAGGATTTTTCAGGTCATTTACTAGATTCTAGCGCTAATC
TGTTGACAATTACAGATACTTATTTAGAGTTAGCTCGTCGTGTTGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTGTTTTC
ATTCTATGACCCAGAAGTTATGGCATTGAGTCAGGAAGATTACCAAGCTTTTCTTGCGGAAACACCTGATTTAAAAAGGT
ATCATCATTTCTTTGACAAATTGTTCCAGACACGTGACCATGTGCTCAGCCATGCTGAAGAGGAATTATTAGCAGGAGCC
CAAGAAATTTTCAACGGCGCTGAAGAAACCTTTAGTATTCTTGATAACGCTGATATTGTCTTTCCAGTAGTTAAAAATGA
TAAGGGGGAAGATGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCATTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGATACCTTGTTAGAAACGGTTAATAAACATTTGCCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATCTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAAGATTACGCAGATCGTGTGCATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCATGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAATT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAGGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGTTTTGCAGCTGCAAGCTATTTAGCAG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCCGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA

Domains

Predicted by InterproScan.

Peptidase family M3 (Peptidase_M3)

(202-581)

Oligopeptidase F (Peptidase_M3_N)

(112-181)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pepF Streptococcus salivarius strain HSISS4

71.048

100

0.71

Multiple sequence alignment