Detailed information NTG0322396

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: FF958_RS10530
• Genome accession: NZ_CP040622
• Coordinates: 2066815..2067858 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: Q99SZ7
• Organism: Staphylococcus aureus strain JKD6004
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2061815..2072858

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FF958_RS10500 (FF958_10500)	-	2062233..2063489 (-)	1257	WP_001795438.1	aminopeptidase	-
FF958_RS10505 (FF958_10505)	-	2063492..2063692 (-)	201	WP_000180461.1	DUF1128 family protein	-
FF958_RS10510 (FF958_10510)	-	2063839..2064303 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
FF958_RS10515 (FF958_10515)	-	2064310..2064585 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
FF958_RS10520 (FF958_10520)	-	2064863..2066080 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
FF958_RS10525 (FF958_10525)	vraR	2066196..2066825 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
FF958_RS10530 (FF958_10530)	vraS	2066815..2067858 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
FF958_RS10535 (FF958_10535)	liaF	2067855..2068556 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
FF958_RS10540 (FF958_10540)	-	2068571..2068957 (-)	387	WP_001110179.1	hypothetical protein	-
FF958_RS10545 (FF958_10545)	map	2069174..2069932 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
FF958_RS10550 (FF958_10550)	-	2070519..2071505 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
FF958_RS10555 (FF958_10555)	-	2071936..2072349 (-)	414	WP_001549145.1	hypothetical protein	-
FF958_RS10560 (FF958_10560)	-	2072378..2072488 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=322396 FF958_RS10530 WP_001017131.1 2066815..2067858(-) (vraS) [Staphylococcus aureus strain JKD6004]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=322396 FF958_RS10530 WP_001017131.1 2066815..2067858(-) (vraS) [Staphylococcus aureus strain JKD6004]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterProScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: Q99SZ7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1