Detailed information NTG0321598

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: SAST45_RS09710
• Genome accession: NZ_CP033114
• Coordinates: 2004252..2005295 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain ST20130945
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1999252..2010295

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SAST45_RS09680 (SAST45_04597)	-	1999673..2000929 (-)	1257	WP_001793983.1	aminopeptidase	-
SAST45_RS09685 (SAST45_02075)	-	2000932..2001132 (-)	201	WP_000180460.1	DUF1128 family protein	-
SAST45_RS09690 (SAST45_02076)	-	2001279..2001743 (+)	465	WP_000228670.1	low molecular weight protein-tyrosine-phosphatase	-
SAST45_RS09695 (SAST45_02077)	-	2001750..2002025 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
SAST45_RS09700 (SAST45_02079)	-	2002303..2003520 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
SAST45_RS09705 (SAST45_04598)	vraR	2003633..2004262 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
SAST45_RS09710 (SAST45_02081)	vraS	2004252..2005295 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
SAST45_RS09715 (SAST45_04599)	liaF	2005292..2005993 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
SAST45_RS09720 (SAST45_02083)	-	2006008..2006394 (-)	387	WP_001110178.1	hypothetical protein	-
SAST45_RS09725 (SAST45_02084)	map	2006611..2007369 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
SAST45_RS09730 (SAST45_02086)	-	2008069..2009055 (+)	987	WP_001014423.1	FUSC family protein	-
SAST45_RS09735 (SAST45_04105)	-	2009244..2009657 (-)	414	WP_001643743.1	hypothetical protein	-
SAST45_RS09740	-	2009686..2009796 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=321598 SAST45_RS09710 WP_001017131.1 2004252..2005295(-) (vraS) [Staphylococcus aureus strain ST20130945]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=321598 SAST45_RS09710 WP_001017131.1 2004252..2005295(-) (vraS) [Staphylococcus aureus strain ST20130945]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGACTT
ATACCATACACTTGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1