Detailed information NTG0321556

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: SAST44_RS10045
• Genome accession: NZ_CP033112
• Coordinates: 2046090..2047133 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain ST20130944
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2041090..2052133

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SAST44_RS10015 (SAST44_03636)	-	2041511..2042767 (-)	1257	WP_001793983.1	aminopeptidase	-
SAST44_RS10020 (SAST44_02096)	-	2042770..2042970 (-)	201	WP_000180460.1	DUF1128 family protein	-
SAST44_RS10025 (SAST44_02097)	-	2043117..2043581 (+)	465	WP_000228670.1	low molecular weight protein-tyrosine-phosphatase	-
SAST44_RS10030 (SAST44_02098)	-	2043588..2043863 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
SAST44_RS10035 (SAST44_02100)	-	2044141..2045358 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
SAST44_RS10040 (SAST44_03637)	vraR	2045471..2046100 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
SAST44_RS10045 (SAST44_03948)	vraS	2046090..2047133 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
SAST44_RS10050 (SAST44_03947)	liaF	2047130..2047831 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
SAST44_RS10055 (SAST44_02105)	-	2047846..2048232 (-)	387	WP_001110178.1	hypothetical protein	-
SAST44_RS10060 (SAST44_02106)	map	2048449..2049207 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
SAST44_RS10065 (SAST44_02108)	-	2049907..2050893 (+)	987	WP_001014423.1	FUSC family protein	-
SAST44_RS10070 (SAST44_03120)	-	2051082..2051495 (-)	414	WP_001643743.1	hypothetical protein	-
SAST44_RS10075	-	2051524..2051634 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=321556 SAST44_RS10045 WP_001017131.1 2046090..2047133(-) (vraS) [Staphylococcus aureus strain ST20130944]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=321556 SAST44_RS10045 WP_001017131.1 2046090..2047133(-) (vraS) [Staphylococcus aureus strain ST20130944]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGACTT
ATACCATACACTTGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1