Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   D4H18_RS04265 Genome accession   NZ_CP032912
Coordinates   859440..861224 (+) Length   594 a.a.
NCBI ID   WP_139522874.1    Uniprot ID   -
Organism   Helicobacter pylori strain 13-A-EK8     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 854440..866224
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  D4H18_RS04235 motB 855206..855979 (+) 774 WP_139522869.1 flagellar motor protein MotB -
  D4H18_RS04240 - 855985..856422 (+) 438 WP_201736683.1 hypothetical protein -
  D4H18_RS04245 - 856491..858152 (+) 1662 WP_139522871.1 ABC transporter permease/substrate-binding protein -
  D4H18_RS04250 - 858154..858810 (+) 657 WP_139522872.1 ATP-binding cassette domain-containing protein -
  D4H18_RS04255 - 858807..858986 (-) 180 WP_000468793.1 hypothetical protein -
  D4H18_RS04260 - 858978..859439 (+) 462 WP_139522873.1 hypothetical protein -
  D4H18_RS04265 uvrC 859440..861224 (+) 1785 WP_139522874.1 excinuclease ABC subunit UvrC Machinery gene
  D4H18_RS04270 - 861235..862500 (+) 1266 WP_139522875.1 homoserine dehydrogenase -
  D4H18_RS04275 - 862500..862844 (+) 345 WP_001211718.1 YraN family protein -
  D4H18_RS04280 trxA 862933..863253 (+) 321 WP_000020199.1 thioredoxin -
  D4H18_RS04285 trxB 863259..864194 (+) 936 WP_000564430.1 thioredoxin-disulfide reductase -
  D4H18_RS04290 - 864403..865224 (+) 822 WP_139522876.1 glycosyltransferase family 25 protein -
  D4H18_RS04295 - 865447..865695 (-) 249 WP_033589505.1 RNA-binding protein -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68594.85 Da        Isoelectric Point: 9.7619

>NTDB_id=320332 D4H18_RS04265 WP_139522874.1 859440..861224(+) (uvrC) [Helicobacter pylori strain 13-A-EK8]
MADLLSSLKNLPNSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSIRNNEITPNHRASLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCEDKITKEEYLKIAKECLEMIENKDKLIKELELKMERLSSNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYGASNKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLMPEQILLS
ACSNEALKELQEFINHKHSKKIALSIPKKGDKLALIEIAMKNAQEIFSQEKTSNEDRILEEARSLFNLECVPYRVEIFDT
SHHSNSQCVGGMVVYENNAFQKDSYRRYHLKGSNEYTQMSELLTRRALDFAKEPPPNLWVIDGGRAQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRAKGGAKDIIHTPSNTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRI

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=320332 D4H18_RS04265 WP_139522874.1 859440..861224(+) (uvrC) [Helicobacter pylori strain 13-A-EK8]
ATGGCTGATTTATTGTCTAGTTTGAAAAACCTTCCTAACAGCAGTGGCGTGTATCAATACTTTGATAAAAACCGCCAACT
GCTCTATATCGGTAAGGCGAAAAATTTAAAAAAACGCATCAAAAGCTATTTTTCCATCCGTAATAATGAAATCACGCCCA
ACCATCGTGCAAGCTTACGCATCCAAATGATGGTCAAACAGATCGCTTTTTTAGAAACCATTTTAGTGGAAAACGAGCAA
GACGCTTTGATTTTAGAAAATTCTTTGATCAAGCAGCTCAAGCCCAAATACAACATTCTTTTAAGAGACGATAAAACTTA
CCCTTATATTTACATGGATTTTTCCACTGATTTCCCTATCCCTTTAATCACACGAAAAATTTTAAAACAGCCTGGCGTTA
AATATTTTGGCCCTTTTACGAGCGGGGCTAAGGATATTTTAGACAGCTTGTATGAATTGCTCCCTTTAGTTCAAAAGAAA
AATTGCATTAAAGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGCAAAGCCCCATGCGAGGATAAAATCACTAA
AGAAGAGTATTTAAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAAACTCATCAAAGAGCTTGAATTAA
AAATGGAGCGCCTTTCTAGTAACTTGCGTTTTGAAGAAGCCCTCATTTATAGAGACAGGATTGCAAAAATCCAAAAAATC
GCCCCTTTCACTTGCATGGATTTGGCGAAACTCTATGATTTGGACATTTTTGCTTTTTATGGCGCAAGCAATAAGGCGGT
CTTAGTGAAAATGTTTATGCGTGGGGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCCCTCAATGGGTTTGACA
CTGATGAGGCGATGAAACAAGCCATTATCAACCATTACCAATCGCATTTGCCTTTGATGCCTGAACAAATCTTATTGAGC
GCTTGTTCTAATGAAGCGCTTAAAGAATTGCAAGAATTTATCAATCATAAACACTCTAAAAAAATCGCTCTTAGCATTCC
TAAAAAAGGCGATAAGCTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAAGAAAAAACCTCTA
ATGAAGATCGGATTTTAGAAGAAGCGCGATCGCTCTTTAATTTAGAGTGCGTACCTTATAGAGTGGAAATCTTTGACACA
AGCCACCATTCAAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAATAACGCCTTCCAAAAAGATTCTTATCGGCG
CTACCATTTAAAAGGCTCTAATGAATACACTCAAATGAGCGAGTTGCTCACCAGAAGGGCTTTAGACTTTGCCAAAGAGC
CACCGCCTAATTTGTGGGTGATCGATGGAGGGAGGGCGCAATTAAACATCGCTTTAGAAATTTTAAAAAGCAGCGGGAGT
TTTGTAGAAGTGATCGCTATTTCTAAAGAAAAAAGGGATTCTAAGGCTTATCGTGCTAAAGGGGGCGCTAAAGACATTAT
CCATACGCCTAGCAATACTTTTAAATTGCTCCCTAGCGACAAACGCTTGCAGTGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCACAGATCCACTAAACTTAAAAACATGAAACAAATCGCTCTTTTAAAAGAAAAGGGCATA
GGAGAAGCCAGCGTGAAAAAATTGTTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAGGAAAAAAA
CGCCGTTTTAAAAAAACGAATCTAA

Domains

Predicted by InterproScan.

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)

GIY-YIG catalytic domain (GIY-YIG)

(15-98)

UvrB/uvrC motif (UVR)

(205-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

97.138

100

0.971

Multiple sequence alignment