Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   D4I92_RS03130 Genome accession   NZ_CP032906
Coordinates   621295..623073 (-) Length   592 a.a.
NCBI ID   WP_139519428.1    Uniprot ID   -
Organism   Helicobacter pylori strain 25-A-EK1     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 616295..628073
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  D4I92_RS03100 - 616677..616925 (+) 249 WP_000790557.1 RNA-binding protein -
  D4I92_RS03105 - 617139..617960 (-) 822 WP_139519430.1 glycosyltransferase family 25 protein -
  D4I92_RS03110 trxB 618318..619253 (-) 936 WP_097704221.1 thioredoxin-disulfide reductase -
  D4I92_RS03115 trxA 619259..619579 (-) 321 WP_000020206.1 thioredoxin -
  D4I92_RS03120 - 619668..620012 (-) 345 WP_001211689.1 YraN family protein -
  D4I92_RS03125 - 620013..621278 (-) 1266 WP_139519429.1 homoserine dehydrogenase -
  D4I92_RS03130 uvrC 621295..623073 (-) 1779 WP_139519428.1 excinuclease ABC subunit UvrC Machinery gene
  D4I92_RS03135 - 623074..623535 (-) 462 WP_101024824.1 hypothetical protein -
  D4I92_RS03140 - 623527..623706 (+) 180 WP_001913919.1 hypothetical protein -
  D4I92_RS03145 - 623718..624359 (-) 642 WP_139519427.1 ATP-binding cassette domain-containing protein -
  D4I92_RS03150 - 624361..626022 (-) 1662 WP_139519426.1 ABC transporter permease/substrate-binding protein -
  D4I92_RS03155 - 626091..626528 (-) 438 WP_001039460.1 hypothetical protein -
  D4I92_RS03160 motB 626534..627307 (-) 774 WP_120815707.1 flagellar motor protein MotB -

Sequence

Protein


Download         Length: 592 a.a.        Molecular weight: 68378.54 Da        Isoelectric Point: 9.6256

>NTDB_id=320204 D4I92_RS03130 WP_139519428.1 621295..623073(-) (uvrC) [Helicobacter pylori strain 25-A-EK1]
MADLLSSLKNLPNSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSIRNNEITPNHRASLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKVLKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCEDKITKEEYLKIAKECLEMIENKDRLIKELELKMERLSNNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYGASNKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLMPEQILLS
ACSNETLKELQEFISHQYSKKIALNIPKKGDKLALIEIAMKNAQEIFSQEKTSNEDLILEEARSLFKLECMPYRVEIFDT
SHHSNSQCVGGMVVYENNAFQKNSYRHYHLKGSDEYAQMSELLTRRALDFAKEPPPNLWVIDGGRAQLNIALEVLKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTPSNTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKK

Nucleotide


Download         Length: 1779 bp        

>NTDB_id=320204 D4I92_RS03130 WP_139519428.1 621295..623073(-) (uvrC) [Helicobacter pylori strain 25-A-EK1]
ATGGCTGATTTATTGTCCAGTTTGAAAAACCTTCCTAATAGTAGTGGCGTGTATCAATATTTTGATAAAAACCGCCAACT
ACTCTATATCGGTAAGGCGAAAAATTTAAAAAAACGCATCAAAAGCTATTTTTCCATCCGTAATAATGAAATCACGCCCA
ATCATCGCGCAAGCTTACGAATCCAAATGATGGTCAAACAAATCGCTTTTTTAGAAACCATTTTAGTGGAAAATGAGCAA
GACGCTTTGATTTTAGAAAATTCTTTGATCAAGCAGCTCAAGCCTAAATACAACATTCTTTTAAGAGACGATAAAACTTA
CCCTTATATTTACATGGATTTTTCCACTGATTTCCCTATCCCTTTAATCACACGAAAAGTTTTAAAACAGCCTGGCGTTA
AATATTTTGGCCCTTTTACAAGCGGGGCTAAAGATATTTTAGACAGCTTGTATGAATTGCTCCCGTTGGTTCAAAAGAAA
AATTGCATCAAGGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGTAAAGCCCCATGCGAGGATAAAATCACCAA
AGAAGAGTATTTAAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAGGCTCATCAAGGAGCTTGAATTAA
AAATGGAGCGCCTTTCTAATAACTTGCGTTTTGAAGAAGCTCTCATTTACAGGGACAGGATTGCAAAAATCCAAAAAATC
GCCCCTTTCACTTGCATGGATTTGGCCAAACTCTATGATTTGGATATTTTTGCTTTTTATGGCGCAAGCAATAAGGCGGT
GTTAGTGAAAATGTTTATGCGTGGGGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCTCTTAATGGGTTTGACA
CTGATGAAGCGATGAAACAAGCCATTATCAATCATTACCAATCGCATTTGCCTTTGATGCCTGAACAAATCTTATTGAGT
GCTTGTTCTAATGAGACGCTTAAAGAATTGCAAGAGTTTATCTCTCATCAATATTCTAAAAAAATCGCTCTTAATATCCC
TAAAAAGGGCGATAAGCTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAAGAAAAAACCTCTA
ATGAAGATCTGATTTTAGAAGAAGCGCGATCGCTCTTCAAATTAGAATGCATGCCTTATAGGGTGGAAATCTTTGACACA
AGCCACCATTCAAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAACAATGCATTCCAAAAAAACTCTTACCGGCA
CTACCATTTAAAAGGCTCTGATGAATACGCTCAAATGAGCGAATTGCTCACCAGAAGGGCTTTAGACTTTGCCAAAGAGC
CACCGCCTAATTTGTGGGTAATAGATGGAGGGAGGGCGCAATTAAACATCGCTTTAGAAGTTTTAAAAAGCAGCGGGAGT
TTTGTAGAAGTGATCGCTATTTCTAAAGAAAAAAGGGATTCTAAGGCTTATCGCTCTAAAGGGGGCGCTAAAGACATTAT
CCATACGCCTAGCAATACTTTTAAATTGCTCCCTAGCGACAAACGCTTGCAGTGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCATAGATCCACTAAACTTAAAAACATGAAACAAATCGCTCTTTTAAAAGAAAAGGGCATA
GGAGAAGCCAGCGTGAAAAAATTGTTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAGGAAAAAAA
CGCTGTTTTAAAAAAATGA

Domains

Predicted by InterproScan.

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)

UvrB/uvrC motif (UVR)

(205-239)

GIY-YIG catalytic domain (GIY-YIG)

(15-98)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

98.311

100

0.983

Multiple sequence alignment