Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   D4K20_RS03430 Genome accession   NZ_CP032903
Coordinates   692731..694515 (-) Length   594 a.a.
NCBI ID   WP_139545134.1    Uniprot ID   -
Organism   Helicobacter pylori strain 173-A-EK1     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 687731..699515
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  D4K20_RS03400 - 688103..688351 (+) 249 WP_000790564.1 RNA-binding protein -
  D4K20_RS03405 - 688579..689400 (-) 822 WP_139545131.1 glycosyltransferase family 25 protein -
  D4K20_RS03410 trxB 689758..690693 (-) 936 WP_139545132.1 thioredoxin-disulfide reductase -
  D4K20_RS03415 trxA 690698..691018 (-) 321 WP_000020210.1 thioredoxin -
  D4K20_RS03420 - 691110..691454 (-) 345 WP_001211689.1 YraN family protein -
  D4K20_RS03425 - 691455..692720 (-) 1266 WP_139545133.1 homoserine dehydrogenase -
  D4K20_RS03430 uvrC 692731..694515 (-) 1785 WP_139545134.1 excinuclease ABC subunit UvrC Machinery gene
  D4K20_RS03435 - 694516..694977 (-) 462 WP_139545135.1 hypothetical protein -
  D4K20_RS03440 - 694969..695148 (+) 180 WP_000468793.1 hypothetical protein -
  D4K20_RS03445 - 695152..695802 (-) 651 WP_139545136.1 ATP-binding cassette domain-containing protein -
  D4K20_RS03450 - 695804..697465 (-) 1662 WP_139545137.1 ABC transporter permease/substrate-binding protein -
  D4K20_RS03455 - 697715..698533 (+) 819 WP_000125522.1 site-specific DNA-methyltransferase -
  D4K20_RS03460 - 698527..699099 (+) 573 WP_000916527.1 Hpy99I family type II restriction endonuclease -
  D4K20_RS03465 - 699113..699349 (-) 237 Protein_645 osmoprotection protein -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68650.99 Da        Isoelectric Point: 9.7912

>NTDB_id=320141 D4K20_RS03430 WP_139545134.1 692731..694515(-) (uvrC) [Helicobacter pylori strain 173-A-EK1]
MADLLSSLKNLPNSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSIRNNEITPNPRASLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCENKITKEEYLKIAKECLEMIENKDRLIKELELKMERLSNNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYGASNKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLIPEQILLN
TCSNEALKELQEFISHQYSKKIALSIPKKGDKLALIEIAMKNAQEIFSQEKTSNEDLILEEVRSLFKLECVPYRVEIFDT
SHHANSQCVGGMVVYENHAFQKNSYRRYHLKGSNEYAQMSELLTRRALDFAKDPPPNLWVIDGGRAQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTPNNTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRI

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=320141 D4K20_RS03430 WP_139545134.1 692731..694515(-) (uvrC) [Helicobacter pylori strain 173-A-EK1]
ATGGCTGATTTATTGTCCAGTTTGAAAAACCTTCCTAATAGCAGTGGCGTGTATCAATATTTTGATAAAAACCGCCAATT
ACTCTATATCGGTAAGGCGAAAAATTTAAAAAAGCGCATCAAAAGCTATTTTTCCATCCGTAATAATGAAATCACGCCCA
ATCCTCGTGCAAGCTTACGCATCCAAATGATGGTCAAACAAATCGCTTTTTTAGAAACCATTTTAGTGGAAAACGAGCAA
GACGCTTTGATTTTGGAAAATTCTTTAATCAAGCAGCTCAAGCCTAAATACAATATTCTTTTAAGAGATGATAAAACTTA
CCCTTATATTTACATGGATTTTTCCACTGATTTCCCTATCCCTTTAATCACACGAAAAATTTTAAAACAGCCTGGCGTTA
AATATTTTGGCCCTTTTACGAGCGGGGCTAAGGATATTTTAGACAGCTTGTATGAATTGCTCCCGTTGGTTCAAAAGAAA
AATTGCATCAAGGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGTAAAGCCCCATGCGAGAATAAAATCACCAA
AGAAGAGTATTTAAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAGGCTCATCAAAGAGCTTGAATTGA
AAATGGAGCGCCTTTCTAACAACTTGCGTTTTGAAGAAGCCCTAATTTACAGGGACAGGATTGCAAAAATCCAAAAAATC
GCCCCTTTCACTTGCATGGATTTGGCCAAACTCTACGATTTGGATATTTTTGCTTTTTATGGCGCAAGCAATAAGGCGGT
GTTAGTGAAAATGTTTATGCGTGGGGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCCCTTAATGGATTTGACA
CTGATGAGGCGATGAAACAAGCCATTATCAATCATTACCAATCGCATTTGCCTTTGATACCAGAACAAATTTTATTGAAC
ACTTGCTCTAATGAAGCGCTTAAAGAATTGCAAGAATTTATCTCCCATCAATATTCTAAAAAAATCGCTCTTAGTATTCC
TAAAAAAGGCGATAAGCTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAAGAAAAAACCTCTA
ATGAAGATCTGATTTTAGAAGAAGTGCGATCGCTCTTCAAATTAGAGTGCGTGCCTTATAGGGTGGAAATCTTTGACACA
AGCCACCATGCCAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAACCATGCATTCCAAAAAAACTCTTATCGGCG
CTACCATTTAAAAGGCTCTAACGAATACGCTCAAATGAGCGAGTTGCTCACCAGAAGGGCTTTAGACTTTGCCAAAGATC
CACCGCCTAATTTGTGGGTGATCGATGGAGGGAGGGCGCAATTAAACATCGCTTTAGAAATTTTAAAAAGCAGCGGGAGT
TTTGTAGAAGTGATCGCTATTTCTAAAGAAAAAAGGGATTCTAAAGCTTATCGCTCTAAAGGGGGCGCTAAAGACATTAT
CCATACGCCTAACAATACTTTTAAATTGCTCCCTAGCGACAAACGCTTGCAGTGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCACAGATCCACTAAACTTAAAAACATGAAACAAATCGCTCTTTTAAAAGAAAAGGGTATA
GGAGAAGCCAGCGTGAAAAAATTATTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAGGAAAAAAA
CGCCGTTTTAAAAAAACGAATCTAA

Domains

Predicted by InterproScan.

UvrB/uvrC motif (UVR)

(205-239)

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)

GIY-YIG catalytic domain (GIY-YIG)

(15-98)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

97.475

100

0.975

Multiple sequence alignment