Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   D4K63_RS02490 Genome accession   NZ_CP032901
Coordinates   480407..482191 (-) Length   594 a.a.
NCBI ID   WP_139532025.1    Uniprot ID   -
Organism   Helicobacter pylori strain 381-A-EK4     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 475407..487191
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  D4K63_RS02460 - 475798..476046 (+) 249 WP_000790557.1 RNA-binding protein -
  D4K63_RS02465 - 476263..477084 (-) 822 WP_139532022.1 glycosyltransferase family 25 protein -
  D4K63_RS02470 trxB 477437..478372 (-) 936 WP_139532023.1 thioredoxin-disulfide reductase -
  D4K63_RS02475 trxA 478378..478698 (-) 321 WP_000020199.1 thioredoxin -
  D4K63_RS02480 - 478787..479131 (-) 345 WP_001211718.1 YraN family protein -
  D4K63_RS02485 - 479131..480396 (-) 1266 WP_139532024.1 homoserine dehydrogenase -
  D4K63_RS02490 uvrC 480407..482191 (-) 1785 WP_139532025.1 excinuclease ABC subunit UvrC Machinery gene
  D4K63_RS02495 - 482192..482653 (-) 462 WP_000437179.1 hypothetical protein -
  D4K63_RS02500 - 482645..482824 (+) 180 WP_000468793.1 hypothetical protein -
  D4K63_RS02505 - 482836..483477 (-) 642 WP_139532026.1 ATP-binding cassette domain-containing protein -
  D4K63_RS02510 - 483479..485140 (-) 1662 WP_139532858.1 ABC transporter permease/substrate-binding protein -
  D4K63_RS02515 - 485209..485646 (-) 438 WP_201736683.1 hypothetical protein -
  D4K63_RS02520 motB 485652..486425 (-) 774 WP_139532027.1 flagellar motor protein MotB -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68539.75 Da        Isoelectric Point: 9.7529

>NTDB_id=320098 D4K63_RS02490 WP_139532025.1 480407..482191(-) (uvrC) [Helicobacter pylori strain 381-A-EK4]
MADLLSSLKNLSSSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSIRNNEITPNHRASLRIQMMVKQIASLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCENKITKEEYLKIAKECLEMIENKDRLIKELELKMERLSNNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYGASNKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLIPEQILLN
TCSNEALKELQEFISHQYSKKIALSIPKKGDKLALIEIAMKNAQEIFSQEKTSNEDLILEEARSLFKLECVPYRVEIFDT
SHHANSQCVGGMVVYENHAFQKNSYRRYHLKGSNEYAQMSELLTRRALDFAKDPPPNLWVIDGGRAQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTPSDTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRI

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=320098 D4K63_RS02490 WP_139532025.1 480407..482191(-) (uvrC) [Helicobacter pylori strain 381-A-EK4]
ATGGCTGATTTATTGTCCAGTTTGAAAAACCTTTCTAGTAGCAGTGGCGTGTATCAATATTTTGATAAAAACCGCCAATT
ACTCTATATCGGTAAGGCGAAAAATTTAAAAAAACGCATCAAAAGCTATTTTTCCATCCGTAATAATGAAATCACGCCCA
ATCATCGCGCTAGCTTACGAATCCAAATGATGGTCAAACAAATCGCTTCTTTAGAAACCATTTTAGTGGAAAACGAGCAA
GACGCTTTGATTTTAGAAAATTCTTTAATCAAGCAGCTCAAGCCCAAATACAACATTCTTTTAAGAGACGATAAAACTTA
CCCCTATATTTATATGGATTTTTCCACTGATTTCCCTATCCCTTTAATCACACGAAAAATTTTAAAACAGCCTGGCGTTA
AATATTTTGGCCCTTTTACGAGCGGGGCTAAGGATATTTTAGACAGCTTGTATGAATTGCTCCCTTTAGTTCAAAAGAAA
AATTGCATCAAGGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGTAAAGCCCCATGCGAGAATAAAATCACCAA
AGAAGAGTATTTAAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAGGCTCATCAAAGAGCTTGAATTGA
AAATGGAGCGCCTTTCTAACAACTTGCGTTTTGAAGAAGCCCTAATTTACAGGGACAGGATTGCAAAAATCCAAAAAATC
GCCCCTTTCACTTGCATGGATTTGGCCAAACTCTACGATTTGGATATTTTTGCTTTTTATGGCGCAAGCAATAAGGCGGT
GTTAGTGAAAATGTTTATGCGTGGGGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCCCTTAATGGATTTGACA
CTGATGAAGCGATGAAACAAGCCATTATCAATCATTACCAATCGCATTTGCCTTTGATACCAGAACAAATTTTATTGAAC
ACTTGCTCTAATGAAGCGCTTAAAGAATTGCAAGAATTTATCTCCCATCAATATTCTAAAAAAATCGCTCTTAGTATTCC
TAAAAAAGGCGATAAGCTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAAGAAAAAACCTCTA
ATGAAGATCTGATTTTAGAAGAAGCGCGATCGCTCTTCAAATTAGAGTGCGTGCCTTATAGGGTGGAAATCTTTGACACA
AGCCACCATGCCAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAACCATGCATTCCAAAAAAACTCTTATCGGCG
CTACCATTTAAAAGGCTCTAACGAATACGCTCAAATGAGCGAGTTGCTCACCAGAAGGGCTTTAGACTTTGCCAAAGATC
CACCGCCTAATTTGTGGGTGATCGATGGAGGGAGGGCGCAATTAAACATCGCTTTAGAAATTTTAAAAAGCAGCGGGAGT
TTTGTAGAAGTGATCGCTATTTCTAAAGAAAAAAGGGATTCTAAAGCTTATCGCTCTAAAGGGGGCGCTAAAGACATTAT
CCATACGCCTAGCGATACTTTTAAATTGCTCCCTAGCGACAAACGCTTGCAGTGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCACAGATCCACTAAACTTAAAAACATGAAACAAATCGCTCTTTTAAAAGAAAAGGGCATA
GGAGAAGCCAGCGTGAAAAAATTATTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAGGAAAAAAA
CGCCGTTTTAAAAAAACGAATCTAA

Domains

Predicted by InterproScan.

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)

UvrB/uvrC motif (UVR)

(205-239)

GIY-YIG catalytic domain (GIY-YIG)

(15-98)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

97.643

100

0.976

Multiple sequence alignment